Gp350-targeted CAR-T therapy in EBV-positive Burkitt lymphoma: pre-clinical development of gp350 CAR-T

Gp350-targeted CAR-T therapy in EBV-positive Burkitt lymphoma: pre-clinical development of gp350 CAR-T

Abstract Background Epstein-Barr virus (EBV) is an oncovirus belonging to the herpesvirus family, associated with the pathogenesis of multiple malignancies, particularly Burkitt lymphoma (BL). The virus remains latent in host cells and plays a critical role in tumor progression through various mecha...

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Main Authors: Jiajia Wang, Huiping Wang, Yangyang Ding, Nengneng Cao, Fengya Nan, Fan Wu, Cong Li, Xue Liang, Meng Xiao, Jinjing Guo, Zhimai Gao, Li Yan, Tielin Zhou, Yanli Li, Zhimin Zhai
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Translational Medicine
Subjects:
CAR-T target research
Gp350
EBV
Burkitt lymphoma
Immunotherapy
Online Access:https://doi.org/10.1186/s12967-025-06188-w
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