Irisin: An influential perspective on the protective effect of metformin on aortic and cardiac aging in rats
Aim: Irisin, a polypeptide hormone, demonstrates a protective function in metabolic diseases and has been observed to enhance endothelial functions. It regulates energy metabolism, fat tissue and glucose metabolism. The predictive value of irisin for the effects of metformin on cardiac and aortic ag...
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| Format: | Article |
| Language: | English |
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Turkish National Vascular and Endovascular Surgery Society
2025-03-01
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| Series: | Turkish Journal of Vascular Surgery |
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| Online Access: | https://turkishjournalofvascularsurgery.org//?mno=242892 |
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| author | Ozgur Baris Gulcin Gacar Burak Acar Feride Ipek Komsuoglu Celikyurt Yusufhan Yazir Tijen Utkan |
| author_facet | Ozgur Baris Gulcin Gacar Burak Acar Feride Ipek Komsuoglu Celikyurt Yusufhan Yazir Tijen Utkan |
| author_sort | Ozgur Baris |
| collection | DOAJ |
| description | Aim: Irisin, a polypeptide hormone, demonstrates a protective function in metabolic diseases and has been observed to enhance endothelial functions. It regulates energy metabolism, fat tissue and glucose metabolism. The predictive value of irisin for the effects of metformin on cardiac and aortic aging in an aged rat model was evaluated by quantitative and histological confirmation.
Material and Methods: A total of twenty-four rats were used in our study. The subjects were equally distributed among four intervention groups: young control group (24 months). The effect of senescence on the heart and aortic tissues, inflammatory and oxidative stress markers, and proliferation indicators (Ki-67, PDGFR-β, TNF-α, IL-1β, NF-κB, TGF-β, e-NOS, and SOD-1) were evaluated with RT-PCR analyses quantitatively. Serum sampling was conducted to determine irisin levels. A histomorphological and immunhistochemical analysis of the heart and aorta sections was performed.
Results: Metformin treatment altered irisin levels in young and old rats compared to controls. Irisin concentrations were higher in metformin-treated rats: 2.57 (0.39) versus 1.89 (0.16) in young rats, and 1.79 (0.31) versus 1.19 (0.22) in old rats (P [Turk J Vasc Surg 2025; 34(1.000): 61-9] |
| format | Article |
| id | doaj-art-a6a4e7eabc95409b966af1cdf82e04fd |
| institution | Kabale University |
| issn | 2667-5080 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Turkish National Vascular and Endovascular Surgery Society |
| record_format | Article |
| series | Turkish Journal of Vascular Surgery |
| spelling | doaj-art-a6a4e7eabc95409b966af1cdf82e04fd2025-08-20T03:41:39ZengTurkish National Vascular and Endovascular Surgery SocietyTurkish Journal of Vascular Surgery2667-50802025-03-01341619242892Irisin: An influential perspective on the protective effect of metformin on aortic and cardiac aging in ratsOzgur Baris0Gulcin Gacar1Burak Acar2Feride Ipek Komsuoglu Celikyurt3Yusufhan Yazir4Tijen Utkan5Department of Cardiovascular Surgery, School of Medicine, Kocaeli University, Kocaeli, Turkey. Center for Stem Cell and Gene Therapies Research and Practice, Institute of Health Sciences, Kocaeli University, Kocaeli, Turkey. Department of Cardiology, School of Medicine, Kocaeli University, Kocaeli, Turkey. Department of Pharmacology, School of Medicine, Kocaeli University, Kocaeli, Turkey Center for Stem Cell and Gene Therapies Research and Practice, Institute of Health Sciences, Kocaeli University, Kocaeli, Turkey & Department of Histology and Embryology, School of Medicine, Kocaeli University, Kocaeli, Turkey. Department of Pharmacology, School of Medicine, Kocaeli University, Kocaeli, Turkey.Aim: Irisin, a polypeptide hormone, demonstrates a protective function in metabolic diseases and has been observed to enhance endothelial functions. It regulates energy metabolism, fat tissue and glucose metabolism. The predictive value of irisin for the effects of metformin on cardiac and aortic aging in an aged rat model was evaluated by quantitative and histological confirmation. Material and Methods: A total of twenty-four rats were used in our study. The subjects were equally distributed among four intervention groups: young control group (24 months). The effect of senescence on the heart and aortic tissues, inflammatory and oxidative stress markers, and proliferation indicators (Ki-67, PDGFR-β, TNF-α, IL-1β, NF-κB, TGF-β, e-NOS, and SOD-1) were evaluated with RT-PCR analyses quantitatively. Serum sampling was conducted to determine irisin levels. A histomorphological and immunhistochemical analysis of the heart and aorta sections was performed. Results: Metformin treatment altered irisin levels in young and old rats compared to controls. Irisin concentrations were higher in metformin-treated rats: 2.57 (0.39) versus 1.89 (0.16) in young rats, and 1.79 (0.31) versus 1.19 (0.22) in old rats (P [Turk J Vasc Surg 2025; 34(1.000): 61-9]https://turkishjournalofvascularsurgery.org//?mno=242892iirisinmetforminoxidative markerspolymerase chain reactionvascular inflammation |
| spellingShingle | Ozgur Baris Gulcin Gacar Burak Acar Feride Ipek Komsuoglu Celikyurt Yusufhan Yazir Tijen Utkan Irisin: An influential perspective on the protective effect of metformin on aortic and cardiac aging in rats Turkish Journal of Vascular Surgery iirisin metformin oxidative markers polymerase chain reaction vascular inflammation |
| title | Irisin: An influential perspective on the protective effect of metformin on aortic and cardiac aging in rats |
| title_full | Irisin: An influential perspective on the protective effect of metformin on aortic and cardiac aging in rats |
| title_fullStr | Irisin: An influential perspective on the protective effect of metformin on aortic and cardiac aging in rats |
| title_full_unstemmed | Irisin: An influential perspective on the protective effect of metformin on aortic and cardiac aging in rats |
| title_short | Irisin: An influential perspective on the protective effect of metformin on aortic and cardiac aging in rats |
| title_sort | irisin an influential perspective on the protective effect of metformin on aortic and cardiac aging in rats |
| topic | iirisin metformin oxidative markers polymerase chain reaction vascular inflammation |
| url | https://turkishjournalofvascularsurgery.org//?mno=242892 |
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