Interactions between Innate Immunity, Microbiota, and Probiotics
The term “microbiota” means genetic inheritance associated with microbiota, which is about 100 times larger than the guest. The tolerance of the resident bacterial flora is an important key element of immune cell function. A key role in the interaction between the host and the microbiota is played b...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/501361 |
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| author | GianMarco Giorgetti Giovanni Brandimarte Federica Fabiocchi Salvatore Ricci Paolo Flamini Giancarlo Sandri Maria Cristina Trotta Walter Elisei Antonio Penna Piera Giuseppina Lecca Marcello Picchio Antonio Tursi |
| author_facet | GianMarco Giorgetti Giovanni Brandimarte Federica Fabiocchi Salvatore Ricci Paolo Flamini Giancarlo Sandri Maria Cristina Trotta Walter Elisei Antonio Penna Piera Giuseppina Lecca Marcello Picchio Antonio Tursi |
| author_sort | GianMarco Giorgetti |
| collection | DOAJ |
| description | The term “microbiota” means genetic inheritance associated with microbiota, which is about 100 times larger than the guest. The tolerance of the resident bacterial flora is an important key element of immune cell function. A key role in the interaction between the host and the microbiota is played by Paneth cell, which is able to synthesize and secrete proteins and antimicrobial peptides, such as α/β defensins, cathelicidin, 14 β-glycosidases, C-type lectins, and ribonuclease, in response to various stimuli. Recent studies found probiotics able to preserve intestinal homeostasis by downmodulating the immune response and inducing the development of T regulatory cells. Specific probiotic strain, as well as probiotic-driven metabolic products called “postbiotics,” has been recently recognized and it is able to influence innate immunity. New therapeutic approaches based on probiotics are now available, and further treatments based on postbiotics will come in the future. |
| format | Article |
| id | doaj-art-a6a3edb1359749aa9eed0e3edfb5f8fe |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-a6a3edb1359749aa9eed0e3edfb5f8fe2025-08-20T02:20:45ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/501361501361Interactions between Innate Immunity, Microbiota, and ProbioticsGianMarco Giorgetti0Giovanni Brandimarte1Federica Fabiocchi2Salvatore Ricci3Paolo Flamini4Giancarlo Sandri5Maria Cristina Trotta6Walter Elisei7Antonio Penna8Piera Giuseppina Lecca9Marcello Picchio10Antonio Tursi11Digestive Endoscopy & Nutrition Unit, “S. Eugenio” Hospital, Piazzale dell’Umanesimo 10, 00144 Rome, ItalyDivision of Internal Medicine and Gastroenterology, “Cristo Re” Hospital, Via delle Calasanziane 25, 00167 Rome, ItalyClinical Nutrition Unit, “S. Eugenio” Hospital, Piazzale dell’Umanesimo 10, 00144 Rome, ItalyClinical Nutrition Unit, “Umberto I” Hospital, Viale del Policliniuco 185, 00186 Rome, ItalyClinical Nutrition Unit, “Umberto I” Hospital, Viale del Policliniuco 185, 00186 Rome, ItalyClinical Nutrition Unit, “S. Eugenio” Hospital, Piazzale dell’Umanesimo 10, 00144 Rome, ItalyDivision of Internal Medicine, “S. Eugenio” Hospital, Piazzale dell’Umanesimo 10, 00144 Rome, ItalyDivision of Gastroenterology, ASL Roma H, Via Borgo Garibaldi 12, Albano Laziale, 00041 Rome, ItalyDivision of Gastroenterology, “S. Paolo” Hospital, Contrada Capo Scardicchio 82, 00123 Bari, ItalyDivision of Internal Medicine and Gastroenterology, “Cristo Re” Hospital, Via delle Calasanziane 25, 00167 Rome, ItalyDivision of General Surgery, “P. Colombo” Hospital, ASL Roma H, Via Orti Ginnetti 7, Velletri, 00049 Rome, ItalyGastroenterology Service, ASL BAT, Via Torino 49, 76123 Andria, ItalyThe term “microbiota” means genetic inheritance associated with microbiota, which is about 100 times larger than the guest. The tolerance of the resident bacterial flora is an important key element of immune cell function. A key role in the interaction between the host and the microbiota is played by Paneth cell, which is able to synthesize and secrete proteins and antimicrobial peptides, such as α/β defensins, cathelicidin, 14 β-glycosidases, C-type lectins, and ribonuclease, in response to various stimuli. Recent studies found probiotics able to preserve intestinal homeostasis by downmodulating the immune response and inducing the development of T regulatory cells. Specific probiotic strain, as well as probiotic-driven metabolic products called “postbiotics,” has been recently recognized and it is able to influence innate immunity. New therapeutic approaches based on probiotics are now available, and further treatments based on postbiotics will come in the future.http://dx.doi.org/10.1155/2015/501361 |
| spellingShingle | GianMarco Giorgetti Giovanni Brandimarte Federica Fabiocchi Salvatore Ricci Paolo Flamini Giancarlo Sandri Maria Cristina Trotta Walter Elisei Antonio Penna Piera Giuseppina Lecca Marcello Picchio Antonio Tursi Interactions between Innate Immunity, Microbiota, and Probiotics Journal of Immunology Research |
| title | Interactions between Innate Immunity, Microbiota, and Probiotics |
| title_full | Interactions between Innate Immunity, Microbiota, and Probiotics |
| title_fullStr | Interactions between Innate Immunity, Microbiota, and Probiotics |
| title_full_unstemmed | Interactions between Innate Immunity, Microbiota, and Probiotics |
| title_short | Interactions between Innate Immunity, Microbiota, and Probiotics |
| title_sort | interactions between innate immunity microbiota and probiotics |
| url | http://dx.doi.org/10.1155/2015/501361 |
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