Apoptotic Bodies Restore NAD and Mitochondrial Homeostasis in Fibroblasts

Apoptotic Bodies Restore NAD and Mitochondrial Homeostasis in Fibroblasts

Abstract Fibrotic skin diseases are characterized by excessive fibroblast proliferation and pathological extracellular matrix deposition. As a pivotal coenzyme in cellular energetics, NAD homeostasis perturbation is implicated in fibrosis. Multiple studies have demonstrated the therapeutic potential...

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Bibliographic Details
Main Authors: Shutong Qian, Siya Dai, Chunyi Guo, Wenjun Wang, Jiajia Pang, Yichen Shen, Mingyuan Xu, Jie Hu, Wenguo Cui, Xiaoming Sun, Jinghong Xu
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
apoptotic body
mitophagy
NAD homeostasis
skin fibrosis
Online Access:https://doi.org/10.1002/advs.202415691
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