Novel quinazolin-4-one based derivatives bearing 1,2,3-triazole and glycoside moieties as potential cytotoxic agents through dual EGFR and VEGFR-2 inhibitory activity

Novel quinazolin-4-one based derivatives bearing 1,2,3-triazole and glycoside moieties as potential cytotoxic agents through dual EGFR and VEGFR-2 inhibitory activity

Abstract The toxicity that was caused by the developed medications for anticancer treatment is, unfortunately, an earnest problem stemming from the various involved targets, and accordingly, intense research for overcoming such a phenomenon remains indispensable. In the current inquiry, an innovativ...

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Bibliographic Details
Main Authors: Adel A.-H. Abdel-Rahman, Mohamed N. El-Bayaa, Asmaa Sobhy, Eman M. El-Ganzoury, Eman S. Nossier, Hanem M. Awad, Wael A. El-Sayed
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Quinazolin-4-one
1,2,3-Triazole
Glycosides
Cytotoxicity
EGFR
VEGFR-2
Online Access:https://doi.org/10.1038/s41598-024-73171-8
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