Factors in Gestational Diabetes Mellitus Predicting the Needs for Insulin Therapy
Objective. To identify factors predicting the need for insulin therapy in pregnancies complicated by gestational diabetes mellitus (GDM). Methods. A total of 1352 patients with GDM diagnosed by the 75-g/2-h oral glucose tolerance test (OGTT) were enrolled in this study. Univariate and multivariate a...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/4858976 |
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| _version_ | 1832556626879447040 |
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| author | Ya Zhang Jiashen Shao Feifei Li Xianming Xu |
| author_facet | Ya Zhang Jiashen Shao Feifei Li Xianming Xu |
| author_sort | Ya Zhang |
| collection | DOAJ |
| description | Objective. To identify factors predicting the need for insulin therapy in pregnancies complicated by gestational diabetes mellitus (GDM). Methods. A total of 1352 patients with GDM diagnosed by the 75-g/2-h oral glucose tolerance test (OGTT) were enrolled in this study. Univariate and multivariate analysis were performed; receiver operating characteristics (ROC) were also drawn. Results. There was a significant difference in factors such as maternal age, pregestational BMI, first visit SBP, first visit DBP, FBG of first visit, FBG at time of OGTT, 75-g OGTT glucose value (fasting, after 1 h and 2 h), and serum HbA1c level at diagnosis between patients with insulin therapy and patients with medical nutrition therapy (MNT) alone. Multivariate analysis showed that higher FBG at time of OGTT, first 75 g OGTT 2 h plasma glucose, and HbA1c concentration at diagnosis lead to more likely need of insulin therapy. Conclusion. The probability of insulin therapy can be estimated in pregnant women with GDM based on fasting and 2 h glucose values during OGTT and HbA1c value at diagnosis of GDM. |
| format | Article |
| id | doaj-art-a68f19a48e92402e9e98a2c10f0ea7d3 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-a68f19a48e92402e9e98a2c10f0ea7d32025-02-03T05:44:51ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/48589764858976Factors in Gestational Diabetes Mellitus Predicting the Needs for Insulin TherapyYa Zhang0Jiashen Shao1Feifei Li2Xianming Xu3Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University, No. 100 Haining Road, Shanghai 200080, ChinaDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University, No. 100 Haining Road, Shanghai 200080, ChinaDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University, No. 100 Haining Road, Shanghai 200080, ChinaDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University, No. 100 Haining Road, Shanghai 200080, ChinaObjective. To identify factors predicting the need for insulin therapy in pregnancies complicated by gestational diabetes mellitus (GDM). Methods. A total of 1352 patients with GDM diagnosed by the 75-g/2-h oral glucose tolerance test (OGTT) were enrolled in this study. Univariate and multivariate analysis were performed; receiver operating characteristics (ROC) were also drawn. Results. There was a significant difference in factors such as maternal age, pregestational BMI, first visit SBP, first visit DBP, FBG of first visit, FBG at time of OGTT, 75-g OGTT glucose value (fasting, after 1 h and 2 h), and serum HbA1c level at diagnosis between patients with insulin therapy and patients with medical nutrition therapy (MNT) alone. Multivariate analysis showed that higher FBG at time of OGTT, first 75 g OGTT 2 h plasma glucose, and HbA1c concentration at diagnosis lead to more likely need of insulin therapy. Conclusion. The probability of insulin therapy can be estimated in pregnant women with GDM based on fasting and 2 h glucose values during OGTT and HbA1c value at diagnosis of GDM.http://dx.doi.org/10.1155/2016/4858976 |
| spellingShingle | Ya Zhang Jiashen Shao Feifei Li Xianming Xu Factors in Gestational Diabetes Mellitus Predicting the Needs for Insulin Therapy International Journal of Endocrinology |
| title | Factors in Gestational Diabetes Mellitus Predicting the Needs for Insulin Therapy |
| title_full | Factors in Gestational Diabetes Mellitus Predicting the Needs for Insulin Therapy |
| title_fullStr | Factors in Gestational Diabetes Mellitus Predicting the Needs for Insulin Therapy |
| title_full_unstemmed | Factors in Gestational Diabetes Mellitus Predicting the Needs for Insulin Therapy |
| title_short | Factors in Gestational Diabetes Mellitus Predicting the Needs for Insulin Therapy |
| title_sort | factors in gestational diabetes mellitus predicting the needs for insulin therapy |
| url | http://dx.doi.org/10.1155/2016/4858976 |
| work_keys_str_mv | AT yazhang factorsingestationaldiabetesmellituspredictingtheneedsforinsulintherapy AT jiashenshao factorsingestationaldiabetesmellituspredictingtheneedsforinsulintherapy AT feifeili factorsingestationaldiabetesmellituspredictingtheneedsforinsulintherapy AT xianmingxu factorsingestationaldiabetesmellituspredictingtheneedsforinsulintherapy |