Atypical Afta Major Healing after Photodynamic Therapy

The aim of this study is to report a case of atypical Afta Major healing in a patient with recurrent aphthous stomatitis (SAR) with a type of photodynamic therapy. A female patient with SAR affected for about 2 years reported a history of hypothyroidism treated with Levothyroxine. The oral cavity cl...

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Main Authors: Cinzia Casu, Carla Mannu
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:Case Reports in Dentistry
Online Access:http://dx.doi.org/10.1155/2017/8517470
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author Cinzia Casu
Carla Mannu
author_facet Cinzia Casu
Carla Mannu
author_sort Cinzia Casu
collection DOAJ
description The aim of this study is to report a case of atypical Afta Major healing in a patient with recurrent aphthous stomatitis (SAR) with a type of photodynamic therapy. A female patient with SAR affected for about 2 years reported a history of hypothyroidism treated with Levothyroxine. The oral cavity clinical examination showed several major symptomatic ulcers, previously treated with topical and systemic therapies without any benefit. The largest of them is present for more than 40 days, in spite of topical cortisone applications, with significant pain symptoms reported by the patient. It was decided to perform a session of photodynamic therapy with a device that emits a LED light used in combination with a photosensitive reagent (Toluidine blue). The dye was applied on the entire surface of the lesion beyond the margins and even encroaching on healthy tissue. The light diode was turned on with a wavelength of 630 nm with cycles from 30 seconds, 10 consecutive times above it. After a few days, a curious phenomenon happened: healing of Afta Major starting from the center, which was almost completely healed towards the borders of the lesion. No previous literature reports this type of healing. Photodynamic therapy could be a successful treatment for SAR.
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spelling doaj-art-a68d36d733df4940a1fbede087f537712025-08-20T03:38:48ZengWileyCase Reports in Dentistry2090-64472090-64552017-01-01201710.1155/2017/85174708517470Atypical Afta Major Healing after Photodynamic TherapyCinzia Casu0Carla Mannu1Private Practice, Cagliari, ItalyDiabetology, San Michele Hospital, Cagliari, ItalyThe aim of this study is to report a case of atypical Afta Major healing in a patient with recurrent aphthous stomatitis (SAR) with a type of photodynamic therapy. A female patient with SAR affected for about 2 years reported a history of hypothyroidism treated with Levothyroxine. The oral cavity clinical examination showed several major symptomatic ulcers, previously treated with topical and systemic therapies without any benefit. The largest of them is present for more than 40 days, in spite of topical cortisone applications, with significant pain symptoms reported by the patient. It was decided to perform a session of photodynamic therapy with a device that emits a LED light used in combination with a photosensitive reagent (Toluidine blue). The dye was applied on the entire surface of the lesion beyond the margins and even encroaching on healthy tissue. The light diode was turned on with a wavelength of 630 nm with cycles from 30 seconds, 10 consecutive times above it. After a few days, a curious phenomenon happened: healing of Afta Major starting from the center, which was almost completely healed towards the borders of the lesion. No previous literature reports this type of healing. Photodynamic therapy could be a successful treatment for SAR.http://dx.doi.org/10.1155/2017/8517470
spellingShingle Cinzia Casu
Carla Mannu
Atypical Afta Major Healing after Photodynamic Therapy
Case Reports in Dentistry
title Atypical Afta Major Healing after Photodynamic Therapy
title_full Atypical Afta Major Healing after Photodynamic Therapy
title_fullStr Atypical Afta Major Healing after Photodynamic Therapy
title_full_unstemmed Atypical Afta Major Healing after Photodynamic Therapy
title_short Atypical Afta Major Healing after Photodynamic Therapy
title_sort atypical afta major healing after photodynamic therapy
url http://dx.doi.org/10.1155/2017/8517470
work_keys_str_mv AT cinziacasu atypicalaftamajorhealingafterphotodynamictherapy
AT carlamannu atypicalaftamajorhealingafterphotodynamictherapy