Pneumatosis Coli Formation via Counterperfusion Supersaturation in a Patient with Severe Diarrhea
We present the case of an elderly male patient with known multiple myeloma who was hospitalized with profuse watery diarrhea and abdominal pain after a course of induction chemotherapy. Intestinal intramural gas was found on imaging and the diagnosis of pneumatosis intestinalis was confirmed by colo...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/6931747 |
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| _version_ | 1832549395383451648 |
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| author | Eric Vecchio Sehrish Jamot Jason Ferreira |
| author_facet | Eric Vecchio Sehrish Jamot Jason Ferreira |
| author_sort | Eric Vecchio |
| collection | DOAJ |
| description | We present the case of an elderly male patient with known multiple myeloma who was hospitalized with profuse watery diarrhea and abdominal pain after a course of induction chemotherapy. Intestinal intramural gas was found on imaging and the diagnosis of pneumatosis intestinalis was confirmed by colonoscopy. We propose counterperfusion supersaturation as the etiology for this patient’s pneumatosis coli via disruption of homeostasis between nitrogen and hydrogen normally present in the bowel. His condition was successfully treated with antidiarrheal medications and inhaled oxygen as well as intravenous hydration, and he eventually completed multiple myeloma directed chemotherapy with an excellent response. In this report, we discuss how clinicians can improve management of pneumatosis intestinalis by understanding the proposed pathophysiology. |
| format | Article |
| id | doaj-art-a68d050a247f4ecf93ecaaa0c07649e8 |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-a68d050a247f4ecf93ecaaa0c07649e82025-02-03T06:11:28ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362018-01-01201810.1155/2018/69317476931747Pneumatosis Coli Formation via Counterperfusion Supersaturation in a Patient with Severe DiarrheaEric Vecchio0Sehrish Jamot1Jason Ferreira2Rhode Island Hospital and Brown University, USARhode Island Hospital and Brown University, USARhode Island Hospital and Brown University, USAWe present the case of an elderly male patient with known multiple myeloma who was hospitalized with profuse watery diarrhea and abdominal pain after a course of induction chemotherapy. Intestinal intramural gas was found on imaging and the diagnosis of pneumatosis intestinalis was confirmed by colonoscopy. We propose counterperfusion supersaturation as the etiology for this patient’s pneumatosis coli via disruption of homeostasis between nitrogen and hydrogen normally present in the bowel. His condition was successfully treated with antidiarrheal medications and inhaled oxygen as well as intravenous hydration, and he eventually completed multiple myeloma directed chemotherapy with an excellent response. In this report, we discuss how clinicians can improve management of pneumatosis intestinalis by understanding the proposed pathophysiology.http://dx.doi.org/10.1155/2018/6931747 |
| spellingShingle | Eric Vecchio Sehrish Jamot Jason Ferreira Pneumatosis Coli Formation via Counterperfusion Supersaturation in a Patient with Severe Diarrhea Case Reports in Gastrointestinal Medicine |
| title | Pneumatosis Coli Formation via Counterperfusion Supersaturation in a Patient with Severe Diarrhea |
| title_full | Pneumatosis Coli Formation via Counterperfusion Supersaturation in a Patient with Severe Diarrhea |
| title_fullStr | Pneumatosis Coli Formation via Counterperfusion Supersaturation in a Patient with Severe Diarrhea |
| title_full_unstemmed | Pneumatosis Coli Formation via Counterperfusion Supersaturation in a Patient with Severe Diarrhea |
| title_short | Pneumatosis Coli Formation via Counterperfusion Supersaturation in a Patient with Severe Diarrhea |
| title_sort | pneumatosis coli formation via counterperfusion supersaturation in a patient with severe diarrhea |
| url | http://dx.doi.org/10.1155/2018/6931747 |
| work_keys_str_mv | AT ericvecchio pneumatosiscoliformationviacounterperfusionsupersaturationinapatientwithseverediarrhea AT sehrishjamot pneumatosiscoliformationviacounterperfusionsupersaturationinapatientwithseverediarrhea AT jasonferreira pneumatosiscoliformationviacounterperfusionsupersaturationinapatientwithseverediarrhea |