Comparison of Incidence and Clinical Outcomes of COVID-19 among Healthcare Workers in the Prevaccination and Post-vaccination Periods: A Real-world Impact Study
Aim:Real-life data on the effect of coronavirus disease-2019 (COVID-19) vaccination is limited. We aimed to compare the incidence of COVID-19 among healthcare workers (HCWs) in the pre-vaccination and post-vaccination periods during the COVID-19 pandemic and identify associated factors for COVID-19...
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| Format: | Article |
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Galenos Publishing House
2022-09-01
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| Series: | Haseki Tıp Bülteni |
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| author | Serkan Surme Betul Copur Osman Faruk Bayramlar Gulsah Tuncer Yusuf Emre Ozdemir Filiz Pehlivanoglu Gonul Sengoz |
| author_facet | Serkan Surme Betul Copur Osman Faruk Bayramlar Gulsah Tuncer Yusuf Emre Ozdemir Filiz Pehlivanoglu Gonul Sengoz |
| author_sort | Serkan Surme |
| collection | DOAJ |
| description | Aim:Real-life data on the effect of coronavirus disease-2019 (COVID-19) vaccination is limited. We aimed to compare the incidence of COVID-19 among healthcare workers (HCWs) in the pre-vaccination and post-vaccination periods during the COVID-19 pandemic and identify associated factors for COVID-19 development.Methods:In this single-center and cross-sectional study, HCWs employed in a tertiary care hospital were included. Pre-vaccination (14 October, 2020 and 14 January, 2021) and post-vaccination periods (1 March, 2021 and 1 June, 2021) were compared. A subgroup analysis was performed on HCWs without a previous history of COVID-19. Additionally, univariate regression analysis of COVID-19 development in the post-vaccination period was performed.Results:Of 2,922 HCWs, 2,096 (71.7%) were vaccinated. The incidence of COVID-19 was higher in the pre-vaccination period (16.3%) than in the post-vaccination (6.6%) (p<0.01). In the subgroup analysis, the incidence of COVID-19 was 16.6% in the pre-vaccination period and 8.1% in the post-vaccination period (p<0.01). Previous history of COVID-19 (p<0.01) and double-dose vaccination (p<0.01) were associated with a decreased risk of COVID-19 development.Conclusion:This study demonstrates the real-life impact of COVID-19 vaccination in reducing disease development and preventing poor clinical outcomes in a setting where the vaccination rate among HCWs was fairly low. |
| format | Article |
| id | doaj-art-a68cd9a6bf1f4de7a9b8525ef3b72eda |
| institution | Kabale University |
| issn | 1302-0072 2147-2688 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Haseki Tıp Bülteni |
| spelling | doaj-art-a68cd9a6bf1f4de7a9b8525ef3b72eda2025-08-20T03:38:48ZengGalenos Publishing HouseHaseki Tıp Bülteni1302-00722147-26882022-09-0160431031710.4274/haseki.galenos.2022.850513049054Comparison of Incidence and Clinical Outcomes of COVID-19 among Healthcare Workers in the Prevaccination and Post-vaccination Periods: A Real-world Impact StudySerkan Surme0Betul Copur1Osman Faruk Bayramlar2Gulsah Tuncer3Yusuf Emre Ozdemir4Filiz Pehlivanoglu5Gonul Sengoz6 University of Health Sciences Turkey, Istanbul Haseki Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey University of Health Sciences Turkey, Istanbul Haseki Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey Bakirkoy District Health Directorate, Clinic of Public Health, Istanbul, Turkey University of Health Sciences Turkey, Istanbul Haseki Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey University of Health Sciences Turkey, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey University of Health Sciences Turkey, Istanbul Haseki Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey University of Health Sciences Turkey, Istanbul Haseki Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey Aim:Real-life data on the effect of coronavirus disease-2019 (COVID-19) vaccination is limited. We aimed to compare the incidence of COVID-19 among healthcare workers (HCWs) in the pre-vaccination and post-vaccination periods during the COVID-19 pandemic and identify associated factors for COVID-19 development.Methods:In this single-center and cross-sectional study, HCWs employed in a tertiary care hospital were included. Pre-vaccination (14 October, 2020 and 14 January, 2021) and post-vaccination periods (1 March, 2021 and 1 June, 2021) were compared. A subgroup analysis was performed on HCWs without a previous history of COVID-19. Additionally, univariate regression analysis of COVID-19 development in the post-vaccination period was performed.Results:Of 2,922 HCWs, 2,096 (71.7%) were vaccinated. The incidence of COVID-19 was higher in the pre-vaccination period (16.3%) than in the post-vaccination (6.6%) (p<0.01). In the subgroup analysis, the incidence of COVID-19 was 16.6% in the pre-vaccination period and 8.1% in the post-vaccination period (p<0.01). Previous history of COVID-19 (p<0.01) and double-dose vaccination (p<0.01) were associated with a decreased risk of COVID-19 development.Conclusion:This study demonstrates the real-life impact of COVID-19 vaccination in reducing disease development and preventing poor clinical outcomes in a setting where the vaccination rate among HCWs was fairly low. http://www.hasekidergisi.com/archives/archive-detail/article-preview/comparison-of-ncidence-and-clinical-outcomes-of-co/53142 covid-19vaccinationincidencehealthcare workers |
| spellingShingle | Serkan Surme Betul Copur Osman Faruk Bayramlar Gulsah Tuncer Yusuf Emre Ozdemir Filiz Pehlivanoglu Gonul Sengoz Comparison of Incidence and Clinical Outcomes of COVID-19 among Healthcare Workers in the Prevaccination and Post-vaccination Periods: A Real-world Impact Study Haseki Tıp Bülteni covid-19 vaccination incidence healthcare workers |
| title | Comparison of Incidence and Clinical Outcomes of COVID-19 among Healthcare Workers in the Prevaccination and Post-vaccination Periods: A Real-world Impact Study |
| title_full | Comparison of Incidence and Clinical Outcomes of COVID-19 among Healthcare Workers in the Prevaccination and Post-vaccination Periods: A Real-world Impact Study |
| title_fullStr | Comparison of Incidence and Clinical Outcomes of COVID-19 among Healthcare Workers in the Prevaccination and Post-vaccination Periods: A Real-world Impact Study |
| title_full_unstemmed | Comparison of Incidence and Clinical Outcomes of COVID-19 among Healthcare Workers in the Prevaccination and Post-vaccination Periods: A Real-world Impact Study |
| title_short | Comparison of Incidence and Clinical Outcomes of COVID-19 among Healthcare Workers in the Prevaccination and Post-vaccination Periods: A Real-world Impact Study |
| title_sort | comparison of incidence and clinical outcomes of covid 19 among healthcare workers in the prevaccination and post vaccination periods a real world impact study |
| topic | covid-19 vaccination incidence healthcare workers |
| url |
http://www.hasekidergisi.com/archives/archive-detail/article-preview/comparison-of-ncidence-and-clinical-outcomes-of-co/53142
|
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