Bacterial cheating drives the population dynamics of cooperative antibiotic resistance plasmids
Abstract Inactivation of β‐lactam antibiotics by resistant bacteria is a ‘cooperative’ behavior that may allow sensitive bacteria to survive antibiotic treatment. However, the factors that determine the fraction of resistant cells in the bacterial population remain unclear, indicating a fundamental...
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| Format: | Article |
| Language: | English |
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Springer Nature
2013-08-01
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| Series: | Molecular Systems Biology |
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| Online Access: | https://doi.org/10.1038/msb.2013.39 |
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| _version_ | 1849331406248869888 |
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| author | Eugene A Yurtsev Hui Xiao Chao Manoshi S Datta Tatiana Artemova Jeff Gore |
| author_facet | Eugene A Yurtsev Hui Xiao Chao Manoshi S Datta Tatiana Artemova Jeff Gore |
| author_sort | Eugene A Yurtsev |
| collection | DOAJ |
| description | Abstract Inactivation of β‐lactam antibiotics by resistant bacteria is a ‘cooperative’ behavior that may allow sensitive bacteria to survive antibiotic treatment. However, the factors that determine the fraction of resistant cells in the bacterial population remain unclear, indicating a fundamental gap in our understanding of how antibiotic resistance evolves. Here, we experimentally track the spread of a plasmid that encodes a β‐lactamase enzyme through the bacterial population. We find that independent of the initial fraction of resistant cells, the population settles to an equilibrium fraction proportional to the antibiotic concentration divided by the cell density. A simple model explains this behavior, successfully predicting a data collapse over two orders of magnitude in antibiotic concentration. This model also successfully predicts that adding a commonly used β‐lactamase inhibitor will lead to the spread of resistance, highlighting the need to incorporate social dynamics into the study of antibiotic resistance. |
| format | Article |
| id | doaj-art-a689449d8dfc47cc86909eaed2e93960 |
| institution | Kabale University |
| issn | 1744-4292 |
| language | English |
| publishDate | 2013-08-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | Molecular Systems Biology |
| spelling | doaj-art-a689449d8dfc47cc86909eaed2e939602025-08-20T03:46:37ZengSpringer NatureMolecular Systems Biology1744-42922013-08-01911810.1038/msb.2013.39Bacterial cheating drives the population dynamics of cooperative antibiotic resistance plasmidsEugene A Yurtsev0Hui Xiao Chao1Manoshi S Datta2Tatiana Artemova3Jeff Gore4Department of Physics, Massachusetts Institute of TechnologyDepartment of Physics, Massachusetts Institute of TechnologyComputational and Systems Biology Program, Massachusetts Institute of TechnologyDepartment of Physics, Massachusetts Institute of TechnologyDepartment of Physics, Massachusetts Institute of TechnologyAbstract Inactivation of β‐lactam antibiotics by resistant bacteria is a ‘cooperative’ behavior that may allow sensitive bacteria to survive antibiotic treatment. However, the factors that determine the fraction of resistant cells in the bacterial population remain unclear, indicating a fundamental gap in our understanding of how antibiotic resistance evolves. Here, we experimentally track the spread of a plasmid that encodes a β‐lactamase enzyme through the bacterial population. We find that independent of the initial fraction of resistant cells, the population settles to an equilibrium fraction proportional to the antibiotic concentration divided by the cell density. A simple model explains this behavior, successfully predicting a data collapse over two orders of magnitude in antibiotic concentration. This model also successfully predicts that adding a commonly used β‐lactamase inhibitor will lead to the spread of resistance, highlighting the need to incorporate social dynamics into the study of antibiotic resistance.https://doi.org/10.1038/msb.2013.39antibiotic inactivationantibiotic resistancecooperation and cheatingβ‐lactampopulation dynamics |
| spellingShingle | Eugene A Yurtsev Hui Xiao Chao Manoshi S Datta Tatiana Artemova Jeff Gore Bacterial cheating drives the population dynamics of cooperative antibiotic resistance plasmids Molecular Systems Biology antibiotic inactivation antibiotic resistance cooperation and cheating β‐lactam population dynamics |
| title | Bacterial cheating drives the population dynamics of cooperative antibiotic resistance plasmids |
| title_full | Bacterial cheating drives the population dynamics of cooperative antibiotic resistance plasmids |
| title_fullStr | Bacterial cheating drives the population dynamics of cooperative antibiotic resistance plasmids |
| title_full_unstemmed | Bacterial cheating drives the population dynamics of cooperative antibiotic resistance plasmids |
| title_short | Bacterial cheating drives the population dynamics of cooperative antibiotic resistance plasmids |
| title_sort | bacterial cheating drives the population dynamics of cooperative antibiotic resistance plasmids |
| topic | antibiotic inactivation antibiotic resistance cooperation and cheating β‐lactam population dynamics |
| url | https://doi.org/10.1038/msb.2013.39 |
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