Compliance in patients with dietary hyperoxaluria: A cohort study and systematic review
Objective: Hyperoxaluria leads to calcium oxalate crystal formation and subsequent urolithiasis. This study aims to analyse the effect of treatment compliance in hyperoxaluria, firstly by analysis of patients with non-primary hyperoxaluria and secondly via systematic review in patients with any hype...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-04-01
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| Series: | Asian Journal of Urology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388218300158 |
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| author | Derek B. Hennessey Ned Kinnear Gilbert Rice David Curry Siobhan Woolsey Brian Duggan |
| author_facet | Derek B. Hennessey Ned Kinnear Gilbert Rice David Curry Siobhan Woolsey Brian Duggan |
| author_sort | Derek B. Hennessey |
| collection | DOAJ |
| description | Objective: Hyperoxaluria leads to calcium oxalate crystal formation and subsequent urolithiasis. This study aims to analyse the effect of treatment compliance in hyperoxaluria, firstly by analysis of patients with non-primary hyperoxaluria and secondly via systematic review in patients with any hyperoxaluria. Methods: In a retrospective cohort study, adults with non-primary hyperoxaluria managed with dietary counselling in 2013 were enrolled. Twenty-four-hour (24 h) urine collections initially and at 6 months were obtained. Compliance was assessed by self-reported dietary compliance and 24 h urinary volume >2 L. Patients were followed for 24 months. Primary outcomes were urinary oxalate and calcium 24 h load at 6 months, and urolithiasis-related procedural rates at 24 months. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-compatible systematic review of compliance among hyperoxaluric patients was performed. Results: In the cohort study, of 19 eligible patients (4 female) with median age 52 years, 10 (53%) were considered compliant. Compared with the non-compliant group, these patients had significantly increased subsequent 24 h urinary volume (2250 mL vs. 1600 mL; p = 0.008) and lower procedural rates (10% vs. 56%; p = 0.033). Subsequent 24 h urinary oxalate load was non-significantly lower in compliant patients. Systematic review regarding compliance in hyperoxaluric patients revealed five studies. Only one utilised dietary counselling or analysed compliant vs. non-compliant patients, finding no difference. None examined the effect of compliance on procedural rates. Conclusion: Hyperoxaluria is an important cause of recurrent urolithiasis. Increasing fluid intake and reducing dietary oxalate reduce the risk of operative intervention and remain fundamental to the treatment of hyperoxaluria. Keywords: Hyperoxaluria, Urolithiasis, Recurrent stone former, Metabolic stone disease |
| format | Article |
| id | doaj-art-a686f74ac9494df78edf7dd0e2bed1fb |
| institution | DOAJ |
| issn | 2214-3882 |
| language | English |
| publishDate | 2019-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj-art-a686f74ac9494df78edf7dd0e2bed1fb2025-08-20T03:09:57ZengElsevierAsian Journal of Urology2214-38822019-04-016220020710.1016/j.ajur.2018.03.002Compliance in patients with dietary hyperoxaluria: A cohort study and systematic reviewDerek B. Hennessey0Ned Kinnear1Gilbert Rice2David Curry3Siobhan Woolsey4Brian Duggan5Department of Urology, Belfast City Hospital, Belfast, United Kingdom; Department of Urology, Austin Hospital, Melbourne, Australia; Corresponding author. Department of Urology, Belfast City Hospital, Belfast, United Kingdom.Department of Urology, Austin Hospital, Melbourne, AustraliaDepartment of Urology, Belfast City Hospital, Belfast, United KingdomDepartment of Urology, Belfast City Hospital, Belfast, United KingdomDepartment of Urology, Belfast City Hospital, Belfast, United KingdomDepartment of Urology, Belfast City Hospital, Belfast, United Kingdom; Department of Urology, Ulster Hospital, Belfast, United KingdomObjective: Hyperoxaluria leads to calcium oxalate crystal formation and subsequent urolithiasis. This study aims to analyse the effect of treatment compliance in hyperoxaluria, firstly by analysis of patients with non-primary hyperoxaluria and secondly via systematic review in patients with any hyperoxaluria. Methods: In a retrospective cohort study, adults with non-primary hyperoxaluria managed with dietary counselling in 2013 were enrolled. Twenty-four-hour (24 h) urine collections initially and at 6 months were obtained. Compliance was assessed by self-reported dietary compliance and 24 h urinary volume >2 L. Patients were followed for 24 months. Primary outcomes were urinary oxalate and calcium 24 h load at 6 months, and urolithiasis-related procedural rates at 24 months. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-compatible systematic review of compliance among hyperoxaluric patients was performed. Results: In the cohort study, of 19 eligible patients (4 female) with median age 52 years, 10 (53%) were considered compliant. Compared with the non-compliant group, these patients had significantly increased subsequent 24 h urinary volume (2250 mL vs. 1600 mL; p = 0.008) and lower procedural rates (10% vs. 56%; p = 0.033). Subsequent 24 h urinary oxalate load was non-significantly lower in compliant patients. Systematic review regarding compliance in hyperoxaluric patients revealed five studies. Only one utilised dietary counselling or analysed compliant vs. non-compliant patients, finding no difference. None examined the effect of compliance on procedural rates. Conclusion: Hyperoxaluria is an important cause of recurrent urolithiasis. Increasing fluid intake and reducing dietary oxalate reduce the risk of operative intervention and remain fundamental to the treatment of hyperoxaluria. Keywords: Hyperoxaluria, Urolithiasis, Recurrent stone former, Metabolic stone diseasehttp://www.sciencedirect.com/science/article/pii/S2214388218300158 |
| spellingShingle | Derek B. Hennessey Ned Kinnear Gilbert Rice David Curry Siobhan Woolsey Brian Duggan Compliance in patients with dietary hyperoxaluria: A cohort study and systematic review Asian Journal of Urology |
| title | Compliance in patients with dietary hyperoxaluria: A cohort study and systematic review |
| title_full | Compliance in patients with dietary hyperoxaluria: A cohort study and systematic review |
| title_fullStr | Compliance in patients with dietary hyperoxaluria: A cohort study and systematic review |
| title_full_unstemmed | Compliance in patients with dietary hyperoxaluria: A cohort study and systematic review |
| title_short | Compliance in patients with dietary hyperoxaluria: A cohort study and systematic review |
| title_sort | compliance in patients with dietary hyperoxaluria a cohort study and systematic review |
| url | http://www.sciencedirect.com/science/article/pii/S2214388218300158 |
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