Synapses-associated research in Parkinson’s disease: an explored trends analysis
BackgroundThe pathological features of Parkinson’s disease (PD) include the formation of Lewy bodies composed mainly of aggregated alpha-synuclein (α-Syn) and extensive neurodegeneration. Synaptic dysfunction is a key factor contributing to disease progression among the various cellular and molecula...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1537119/full |
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| author | Yan-Jun Chen Yan-Jun Chen Ming-Rong Xie Sheng-Qiang Zhou Fang Liu |
| author_facet | Yan-Jun Chen Yan-Jun Chen Ming-Rong Xie Sheng-Qiang Zhou Fang Liu |
| author_sort | Yan-Jun Chen |
| collection | DOAJ |
| description | BackgroundThe pathological features of Parkinson’s disease (PD) include the formation of Lewy bodies composed mainly of aggregated alpha-synuclein (α-Syn) and extensive neurodegeneration. Synaptic dysfunction is a key factor contributing to disease progression among the various cellular and molecular mechanisms of PD. This study aims to analyze the research hotspots, frontier trends, and future directions of PD and synapses.MethodRelevant publications were obtained using the Web of Science database. Software CiteSpace, VOSviewer, and bibliometrix were used for visualization and quantitative analysis.ResultsA total of 3,823 publications were included for analysis, and the number of publications related to the research topic showed an increasing trend from 2001 to 2024. North America, Asia, and Europe were the main research forces with high activity. The United States was the main leader in this field, followed by China and Italy. Emory University was the institution with the largest number of publications. Journal of Neuroscience was the core journal with a large number of publications. Dr. Calabresi, Paolo was a leader in the field of research. High-frequency keywords included PD, α-Syn, synaptic plasticity, basal ganglia, dopamine, substantia-nigra. In recent years, neuroinflammation has been the subject of active research.ConclusionCommunication and collaboration between different countries, institutions, and authors have promoted the development of this field. The research content mainly focused on α-Syn, synaptic plasticity, and mouse model. Neuroinflammation may be the direction of future research. |
| format | Article |
| id | doaj-art-a681c696bd9d4376bef266f01505fdd7 |
| institution | DOAJ |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-a681c696bd9d4376bef266f01505fdd72025-08-20T02:54:37ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-04-011710.3389/fnagi.2025.15371191537119Synapses-associated research in Parkinson’s disease: an explored trends analysisYan-Jun Chen0Yan-Jun Chen1Ming-Rong Xie2Sheng-Qiang Zhou3Fang Liu4Graduate School of Hunan University of Chinese Medicine, Changsha, ChinaNational TCM Master Liu Zuyi Inheritance Studio, The Affiliated Hospital of Hunan Academy of Chinese Medicine, Changsha, ChinaThe First Clinical College of Nanjing University of Chinese Medicine, Nanjing, ChinaNational TCM Master Liu Zuyi Inheritance Studio, The Affiliated Hospital of Hunan Academy of Chinese Medicine, Changsha, ChinaNational TCM Master Liu Zuyi Inheritance Studio, The Affiliated Hospital of Hunan Academy of Chinese Medicine, Changsha, ChinaBackgroundThe pathological features of Parkinson’s disease (PD) include the formation of Lewy bodies composed mainly of aggregated alpha-synuclein (α-Syn) and extensive neurodegeneration. Synaptic dysfunction is a key factor contributing to disease progression among the various cellular and molecular mechanisms of PD. This study aims to analyze the research hotspots, frontier trends, and future directions of PD and synapses.MethodRelevant publications were obtained using the Web of Science database. Software CiteSpace, VOSviewer, and bibliometrix were used for visualization and quantitative analysis.ResultsA total of 3,823 publications were included for analysis, and the number of publications related to the research topic showed an increasing trend from 2001 to 2024. North America, Asia, and Europe were the main research forces with high activity. The United States was the main leader in this field, followed by China and Italy. Emory University was the institution with the largest number of publications. Journal of Neuroscience was the core journal with a large number of publications. Dr. Calabresi, Paolo was a leader in the field of research. High-frequency keywords included PD, α-Syn, synaptic plasticity, basal ganglia, dopamine, substantia-nigra. In recent years, neuroinflammation has been the subject of active research.ConclusionCommunication and collaboration between different countries, institutions, and authors have promoted the development of this field. The research content mainly focused on α-Syn, synaptic plasticity, and mouse model. Neuroinflammation may be the direction of future research.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1537119/fullParkinson’s diseasesynapsessynaptic plasticityneuroinflammationalpha-synuclein |
| spellingShingle | Yan-Jun Chen Yan-Jun Chen Ming-Rong Xie Sheng-Qiang Zhou Fang Liu Synapses-associated research in Parkinson’s disease: an explored trends analysis Frontiers in Aging Neuroscience Parkinson’s disease synapses synaptic plasticity neuroinflammation alpha-synuclein |
| title | Synapses-associated research in Parkinson’s disease: an explored trends analysis |
| title_full | Synapses-associated research in Parkinson’s disease: an explored trends analysis |
| title_fullStr | Synapses-associated research in Parkinson’s disease: an explored trends analysis |
| title_full_unstemmed | Synapses-associated research in Parkinson’s disease: an explored trends analysis |
| title_short | Synapses-associated research in Parkinson’s disease: an explored trends analysis |
| title_sort | synapses associated research in parkinson s disease an explored trends analysis |
| topic | Parkinson’s disease synapses synaptic plasticity neuroinflammation alpha-synuclein |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1537119/full |
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