Does Varicocelectomy Improve Gonadal Function in Men with Hypogonadism and Infertility? Analysis of a Prospective Study
Varicocele in infertile males is associated with Leydig cell dysfunction and hypogonadism. The effect of varicocelectomy on serum testosterone level is not yet established. We analysed 200 heterosexual infertile men diagnosed to have clinical varicocele they were divided into two groups: group 1 (10...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2011/916380 |
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| author | Vasan Sathya Srini Srinivas Belur Veerachari |
| author_facet | Vasan Sathya Srini Srinivas Belur Veerachari |
| author_sort | Vasan Sathya Srini |
| collection | DOAJ |
| description | Varicocele in infertile males is associated with Leydig cell dysfunction and hypogonadism. The effect of varicocelectomy on serum testosterone level is not yet established. We analysed 200 heterosexual infertile men diagnosed to have clinical varicocele they were divided into two groups: group 1 (100 men) had microsurgical varicocelectomy, and group 2 (100 patients) underwent assisted reproduction procedures. All participants had semen analysis, serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, and total testosterone (TT), measured both at recruitment time and 6 months later. In group 1, the mean TT level increased significantly after varicocelectomy (1.644±0.029 to 2.461±0.0198 ng/dL, P<0.0001) and testicular size correlated with the mean change in TT (P=0.001). No similar change was found in group 2. Out of the 100 patients in group 1, 78 had postoperative normalization of TT unlike only 16 men in group 2. |
| format | Article |
| id | doaj-art-a67fa6d9c4e44a55881a9d81bd7bca25 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-a67fa6d9c4e44a55881a9d81bd7bca252025-08-20T03:38:48ZengWileyInternational Journal of Endocrinology1687-83371687-83452011-01-01201110.1155/2011/916380916380Does Varicocelectomy Improve Gonadal Function in Men with Hypogonadism and Infertility? Analysis of a Prospective StudyVasan Sathya Srini0Srinivas Belur Veerachari1Department of Andrology, Ankur Health Care Private Limited, No. 55, 20th Main, 1st Block, Rajajinagar, Bengaluru 560010, IndiaDepartment of Andrology, Ankur Health Care Private Limited, No. 55, 20th Main, 1st Block, Rajajinagar, Bengaluru 560010, IndiaVaricocele in infertile males is associated with Leydig cell dysfunction and hypogonadism. The effect of varicocelectomy on serum testosterone level is not yet established. We analysed 200 heterosexual infertile men diagnosed to have clinical varicocele they were divided into two groups: group 1 (100 men) had microsurgical varicocelectomy, and group 2 (100 patients) underwent assisted reproduction procedures. All participants had semen analysis, serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, and total testosterone (TT), measured both at recruitment time and 6 months later. In group 1, the mean TT level increased significantly after varicocelectomy (1.644±0.029 to 2.461±0.0198 ng/dL, P<0.0001) and testicular size correlated with the mean change in TT (P=0.001). No similar change was found in group 2. Out of the 100 patients in group 1, 78 had postoperative normalization of TT unlike only 16 men in group 2.http://dx.doi.org/10.1155/2011/916380 |
| spellingShingle | Vasan Sathya Srini Srinivas Belur Veerachari Does Varicocelectomy Improve Gonadal Function in Men with Hypogonadism and Infertility? Analysis of a Prospective Study International Journal of Endocrinology |
| title | Does Varicocelectomy Improve Gonadal Function in Men with Hypogonadism and Infertility? Analysis of a Prospective Study |
| title_full | Does Varicocelectomy Improve Gonadal Function in Men with Hypogonadism and Infertility? Analysis of a Prospective Study |
| title_fullStr | Does Varicocelectomy Improve Gonadal Function in Men with Hypogonadism and Infertility? Analysis of a Prospective Study |
| title_full_unstemmed | Does Varicocelectomy Improve Gonadal Function in Men with Hypogonadism and Infertility? Analysis of a Prospective Study |
| title_short | Does Varicocelectomy Improve Gonadal Function in Men with Hypogonadism and Infertility? Analysis of a Prospective Study |
| title_sort | does varicocelectomy improve gonadal function in men with hypogonadism and infertility analysis of a prospective study |
| url | http://dx.doi.org/10.1155/2011/916380 |
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