LASU: An efficient and stable phthalocyanine dye with tolerable safety profile for self-disinfecting anti-COVID textiles activated by ambient light
Background: Recent COVID crisis has demonstrated that modern society urgently needs an accessible protection against mass infections, especially viruses, as the new strains are appearing at an ever-increasing pace and cause severe harm to the population and the world economy. Methods: We have develo...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-02-01
|
| Series: | Photodiagnosis and Photodynamic Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024000176 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850263880916271104 |
|---|---|
| author | Alexander Efimov Christophe Dagallier Céline Frochot Bauyrzhan Myrzakhmetov Philippe Arnoux Tuula Heinonen Marika Mannerström Tarja Toimela Zafar Ahmed Jean Frédéric Audibert Benoit Habermeyer Serge Mordon Robert Bernard Pansu |
| author_facet | Alexander Efimov Christophe Dagallier Céline Frochot Bauyrzhan Myrzakhmetov Philippe Arnoux Tuula Heinonen Marika Mannerström Tarja Toimela Zafar Ahmed Jean Frédéric Audibert Benoit Habermeyer Serge Mordon Robert Bernard Pansu |
| author_sort | Alexander Efimov |
| collection | DOAJ |
| description | Background: Recent COVID crisis has demonstrated that modern society urgently needs an accessible protection against mass infections, especially viruses, as the new strains are appearing at an ever-increasing pace and cause severe harm to the population and the world economy. Methods: We have developed an efficient phthalocyanine photosensitizer LASU, that is suitable for dyeing textiles and allows to prepare reusable self-disinfecting fabrics with strong antiviral properties. The safety profile of LASU was evaluated in accredited laboratories by several in vitro assays according to the OECD-guidelines. Results: The textiles impregnated with LASU phthalocyanine showed a significant antiviral photodynamic effect even under moderate indoor and outdoor light. The dye did not show any genotoxic potential in human lymphocyte micronucleus assay. It showed a possible indication for eye irritation in human EpiOcular™ model and was phototoxic when tested in mouse BALB/c 3T3 cell test in the presence and absence of UVA-irradiation. Conclusion: Novel phthalocyanine-dyed textiles are suitable for general use as self-disinfecting antiviral barriers and materials in hospitals, households, and public places. The safety profile of LASU is the phototoxic effect which is related to LASU´s mode of action. |
| format | Article |
| id | doaj-art-a67d69fd72364bc79ca058cdd73be2b2 |
| institution | OA Journals |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-a67d69fd72364bc79ca058cdd73be2b22025-08-20T01:54:51ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-014510397810.1016/j.pdpdt.2024.103978LASU: An efficient and stable phthalocyanine dye with tolerable safety profile for self-disinfecting anti-COVID textiles activated by ambient lightAlexander Efimov0Christophe Dagallier1Céline Frochot2Bauyrzhan Myrzakhmetov3Philippe Arnoux4Tuula Heinonen5Marika Mannerström6Tarja Toimela7Zafar Ahmed8Jean Frédéric Audibert9Benoit Habermeyer10Serge Mordon11Robert Bernard Pansu12Tampere University, Tampere, Finland; Corresponding author.Christex Co., 115 All. de la Pièce du Lavoir, 91190 Gif-sur-Yvette, FranceUniversité de Lorraine, CNRS, LRGP, F-54000 Nancy, FranceUniversité de Lorraine, CNRS, LRGP, F-54000 Nancy, FranceUniversité de Lorraine, CNRS, LRGP, F-54000 Nancy, FranceTampere University, Tampere, FinlandTampere University, Tampere, FinlandTampere University, Tampere, FinlandTampere University, Tampere, FinlandLuMIn UMR9024 du CNRS, ENS Paris-Saclay, Université Paris-Saclay, CentraleSupélec, Gif sur Yvette, FrancePorphyChem SAS, 390 Rue Charles de Freycinet, 21600 Longvic, FranceHemerion Therapeutics, Villeneuve d'Ascq, FranceLuMIn UMR9024 du CNRS, ENS Paris-Saclay, Université Paris-Saclay, CentraleSupélec, Gif sur Yvette, FranceBackground: Recent COVID crisis has demonstrated that modern society urgently needs an accessible protection against mass infections, especially viruses, as the new strains are appearing at an ever-increasing pace and cause severe harm to the population and the world economy. Methods: We have developed an efficient phthalocyanine photosensitizer LASU, that is suitable for dyeing textiles and allows to prepare reusable self-disinfecting fabrics with strong antiviral properties. The safety profile of LASU was evaluated in accredited laboratories by several in vitro assays according to the OECD-guidelines. Results: The textiles impregnated with LASU phthalocyanine showed a significant antiviral photodynamic effect even under moderate indoor and outdoor light. The dye did not show any genotoxic potential in human lymphocyte micronucleus assay. It showed a possible indication for eye irritation in human EpiOcular™ model and was phototoxic when tested in mouse BALB/c 3T3 cell test in the presence and absence of UVA-irradiation. Conclusion: Novel phthalocyanine-dyed textiles are suitable for general use as self-disinfecting antiviral barriers and materials in hospitals, households, and public places. The safety profile of LASU is the phototoxic effect which is related to LASU´s mode of action.http://www.sciencedirect.com/science/article/pii/S1572100024000176Photodynamic antimicrobial chemotherapyPhthalocyanineAntiviralSelf-disinfecting textilePhotodynamic therapy |
| spellingShingle | Alexander Efimov Christophe Dagallier Céline Frochot Bauyrzhan Myrzakhmetov Philippe Arnoux Tuula Heinonen Marika Mannerström Tarja Toimela Zafar Ahmed Jean Frédéric Audibert Benoit Habermeyer Serge Mordon Robert Bernard Pansu LASU: An efficient and stable phthalocyanine dye with tolerable safety profile for self-disinfecting anti-COVID textiles activated by ambient light Photodiagnosis and Photodynamic Therapy Photodynamic antimicrobial chemotherapy Phthalocyanine Antiviral Self-disinfecting textile Photodynamic therapy |
| title | LASU: An efficient and stable phthalocyanine dye with tolerable safety profile for self-disinfecting anti-COVID textiles activated by ambient light |
| title_full | LASU: An efficient and stable phthalocyanine dye with tolerable safety profile for self-disinfecting anti-COVID textiles activated by ambient light |
| title_fullStr | LASU: An efficient and stable phthalocyanine dye with tolerable safety profile for self-disinfecting anti-COVID textiles activated by ambient light |
| title_full_unstemmed | LASU: An efficient and stable phthalocyanine dye with tolerable safety profile for self-disinfecting anti-COVID textiles activated by ambient light |
| title_short | LASU: An efficient and stable phthalocyanine dye with tolerable safety profile for self-disinfecting anti-COVID textiles activated by ambient light |
| title_sort | lasu an efficient and stable phthalocyanine dye with tolerable safety profile for self disinfecting anti covid textiles activated by ambient light |
| topic | Photodynamic antimicrobial chemotherapy Phthalocyanine Antiviral Self-disinfecting textile Photodynamic therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024000176 |
| work_keys_str_mv | AT alexanderefimov lasuanefficientandstablephthalocyaninedyewithtolerablesafetyprofileforselfdisinfectinganticovidtextilesactivatedbyambientlight AT christophedagallier lasuanefficientandstablephthalocyaninedyewithtolerablesafetyprofileforselfdisinfectinganticovidtextilesactivatedbyambientlight AT celinefrochot lasuanefficientandstablephthalocyaninedyewithtolerablesafetyprofileforselfdisinfectinganticovidtextilesactivatedbyambientlight AT bauyrzhanmyrzakhmetov lasuanefficientandstablephthalocyaninedyewithtolerablesafetyprofileforselfdisinfectinganticovidtextilesactivatedbyambientlight AT philippearnoux lasuanefficientandstablephthalocyaninedyewithtolerablesafetyprofileforselfdisinfectinganticovidtextilesactivatedbyambientlight AT tuulaheinonen lasuanefficientandstablephthalocyaninedyewithtolerablesafetyprofileforselfdisinfectinganticovidtextilesactivatedbyambientlight AT marikamannerstrom lasuanefficientandstablephthalocyaninedyewithtolerablesafetyprofileforselfdisinfectinganticovidtextilesactivatedbyambientlight AT tarjatoimela lasuanefficientandstablephthalocyaninedyewithtolerablesafetyprofileforselfdisinfectinganticovidtextilesactivatedbyambientlight AT zafarahmed lasuanefficientandstablephthalocyaninedyewithtolerablesafetyprofileforselfdisinfectinganticovidtextilesactivatedbyambientlight AT jeanfredericaudibert lasuanefficientandstablephthalocyaninedyewithtolerablesafetyprofileforselfdisinfectinganticovidtextilesactivatedbyambientlight AT benoithabermeyer lasuanefficientandstablephthalocyaninedyewithtolerablesafetyprofileforselfdisinfectinganticovidtextilesactivatedbyambientlight AT sergemordon lasuanefficientandstablephthalocyaninedyewithtolerablesafetyprofileforselfdisinfectinganticovidtextilesactivatedbyambientlight AT robertbernardpansu lasuanefficientandstablephthalocyaninedyewithtolerablesafetyprofileforselfdisinfectinganticovidtextilesactivatedbyambientlight |