COMPARATIVE ANTICONVULSANT AND ANTIHYPOXIC EFFECTS OF ASTROKS AND MEXIDOL IN INJECTABLE FORM AND 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE SUCCINATE SUBSTANCE
The purpose of this study was to examine in experiment anticonvulsant and antihypoxic action of 2-ethyl-6-methyl-3-hydroxypyridine succinate medications — Astroks in injectable form (vial of 100 mg in 2 ml) compared with Mexidol injectable form (vial of 100 mg in 2 ml) and the substance 2-ethyl-6- m...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2016-06-01
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| Series: | Эпилепсия и пароксизмальные состояния |
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| Online Access: | https://www.epilepsia.su/jour/article/view/95 |
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| author | T. A. Voronina S. A. Litvinova L. N. Nerobkova G. G. Avakyan I. O. Gaidukov G. N. Avakyan |
| author_facet | T. A. Voronina S. A. Litvinova L. N. Nerobkova G. G. Avakyan I. O. Gaidukov G. N. Avakyan |
| author_sort | T. A. Voronina |
| collection | DOAJ |
| description | The purpose of this study was to examine in experiment anticonvulsant and antihypoxic action of 2-ethyl-6-methyl-3-hydroxypyridine succinate medications — Astroks in injectable form (vial of 100 mg in 2 ml) compared with Mexidol injectable form (vial of 100 mg in 2 ml) and the substance 2-ethyl-6- methyl-3-hydroxypyridine succinate (EMHPS). Materials and methods. Simulation of primary generalized eizures was performed using the maximal electroshock (MES) and pentylenetetrazole injection. Antihypoxic effects of drugs was studied on the model of normobaric hypoxia with hypercapnia.Results: it was found that astroks injection at a dose of 200 mg/kg has a similar antihypoxic and anticonvulsant efficacy with EMHPS substance. Compared to injectable form of Meksidol astroks has similar efficacy in the test of antagonism with MES. Astroks exceeds the effect of Mexidol in the test of antagonism with pentylenetetrazole and has more severe antihypoxic action.Conclusion. Аstroks injectable has pronounced antihypoxic and anticonvulsant action in the experiment which have some advantages over injectable Meksidol. |
| format | Article |
| id | doaj-art-a6769c8255be462d9b3ff89e3f673ff6 |
| institution | DOAJ |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| publishDate | 2016-06-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj-art-a6769c8255be462d9b3ff89e3f673ff62025-08-20T03:19:34ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882016-06-0181758210.17749/2077-8333.2016.8.1.075-08294COMPARATIVE ANTICONVULSANT AND ANTIHYPOXIC EFFECTS OF ASTROKS AND MEXIDOL IN INJECTABLE FORM AND 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE SUCCINATE SUBSTANCET. A. Voronina0S. A. Litvinova1L. N. Nerobkova2G. G. Avakyan3I. O. Gaidukov4G. N. Avakyan5Institute of Pharmacology named V. V. Zakusov, MoscowInstitute of Pharmacology named V. V. Zakusov, MoscowInstitute of Pharmacology named V. V. Zakusov, MoscowThe Russian National Research Medical University named after N. I. Pirogov of the Ministry of Health of the Russian Federation, MoscowInstitute of Pharmacology named V. V. Zakusov, MoscowThe Russian National Research Medical University named after N. I. Pirogov of the Ministry of Health of the Russian Federation, MoscowThe purpose of this study was to examine in experiment anticonvulsant and antihypoxic action of 2-ethyl-6-methyl-3-hydroxypyridine succinate medications — Astroks in injectable form (vial of 100 mg in 2 ml) compared with Mexidol injectable form (vial of 100 mg in 2 ml) and the substance 2-ethyl-6- methyl-3-hydroxypyridine succinate (EMHPS). Materials and methods. Simulation of primary generalized eizures was performed using the maximal electroshock (MES) and pentylenetetrazole injection. Antihypoxic effects of drugs was studied on the model of normobaric hypoxia with hypercapnia.Results: it was found that astroks injection at a dose of 200 mg/kg has a similar antihypoxic and anticonvulsant efficacy with EMHPS substance. Compared to injectable form of Meksidol astroks has similar efficacy in the test of antagonism with MES. Astroks exceeds the effect of Mexidol in the test of antagonism with pentylenetetrazole and has more severe antihypoxic action.Conclusion. Аstroks injectable has pronounced antihypoxic and anticonvulsant action in the experiment which have some advantages over injectable Meksidol.https://www.epilepsia.su/jour/article/view/95epilepsyprimary generalized seizuresmespentylenetetrazolehypoxiamexidol. |
| spellingShingle | T. A. Voronina S. A. Litvinova L. N. Nerobkova G. G. Avakyan I. O. Gaidukov G. N. Avakyan COMPARATIVE ANTICONVULSANT AND ANTIHYPOXIC EFFECTS OF ASTROKS AND MEXIDOL IN INJECTABLE FORM AND 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE SUCCINATE SUBSTANCE Эпилепсия и пароксизмальные состояния epilepsy primary generalized seizures mes pentylenetetrazole hypoxia mexidol. |
| title | COMPARATIVE ANTICONVULSANT AND ANTIHYPOXIC EFFECTS OF ASTROKS AND MEXIDOL IN INJECTABLE FORM AND 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE SUCCINATE SUBSTANCE |
| title_full | COMPARATIVE ANTICONVULSANT AND ANTIHYPOXIC EFFECTS OF ASTROKS AND MEXIDOL IN INJECTABLE FORM AND 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE SUCCINATE SUBSTANCE |
| title_fullStr | COMPARATIVE ANTICONVULSANT AND ANTIHYPOXIC EFFECTS OF ASTROKS AND MEXIDOL IN INJECTABLE FORM AND 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE SUCCINATE SUBSTANCE |
| title_full_unstemmed | COMPARATIVE ANTICONVULSANT AND ANTIHYPOXIC EFFECTS OF ASTROKS AND MEXIDOL IN INJECTABLE FORM AND 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE SUCCINATE SUBSTANCE |
| title_short | COMPARATIVE ANTICONVULSANT AND ANTIHYPOXIC EFFECTS OF ASTROKS AND MEXIDOL IN INJECTABLE FORM AND 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE SUCCINATE SUBSTANCE |
| title_sort | comparative anticonvulsant and antihypoxic effects of astroks and mexidol in injectable form and 2 ethyl 6 methyl 3 hydroxypyridine succinate substance |
| topic | epilepsy primary generalized seizures mes pentylenetetrazole hypoxia mexidol. |
| url | https://www.epilepsia.su/jour/article/view/95 |
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