Maternal hepatitis B e antigen can be an indicator for antiviral prophylaxis of perinatal transmission of hepatitis B virus
As a high-risk factor of perinatal HBV transmission, the potential role of maternal hepatitis B e antigen (HBeAg) to guide antiviral prophylaxis has not yet been fully reported. This large prospective cohort study enrolled 1177 hepatitis B surface antigen (HBsAg)-positive pregnant women without anti...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-01-01
|
| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2021.1899055 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849312730169737216 |
|---|---|
| author | Ying Lu Yarong Song Xiangjun Zhai Fengcai Zhu Jianxun Liu Zhanjun Chang Yi Li Yiwei Xiao Lili Li Minmin Liu Jia Liu Zhongping Duan Huaibin Zou Hui Zhuang Jie Wang Jie Li |
| author_facet | Ying Lu Yarong Song Xiangjun Zhai Fengcai Zhu Jianxun Liu Zhanjun Chang Yi Li Yiwei Xiao Lili Li Minmin Liu Jia Liu Zhongping Duan Huaibin Zou Hui Zhuang Jie Wang Jie Li |
| author_sort | Ying Lu |
| collection | DOAJ |
| description | As a high-risk factor of perinatal HBV transmission, the potential role of maternal hepatitis B e antigen (HBeAg) to guide antiviral prophylaxis has not yet been fully reported. This large prospective cohort study enrolled 1177 hepatitis B surface antigen (HBsAg)-positive pregnant women without antiviral treatment and their newborns. HBeAg, HBsAg, and viral load in maternal serum collected before delivery were measured. All the newborns were given standard passive–active immunoprophylaxis within 12 h after birth, and post-vaccination serologic testing was performed at 7 (±7d) months of age. The results revealed that 20 of the 1177 infants (1.70%) were immunoprophylaxis failure, and all their mothers were HBeAg positive. Maternal quantitative HBeAg was positively correlated with viral load (r = 0.83; P < .0001) and quantitative HBsAg (r = 0.68; P < .0001). The area under the receiver operating characteristic curve (AUC) for predicting immunoprophylaxis failure by maternal HBeAg was comparable to that by maternal viral load (0.871 vs 0.893; P = .441) and HBsAg (0.871 vs 0.871; P = .965). The optimal cutoff value of maternal quantitative HBeAg to predict perinatal infection was 2.21 log10 PEI U/mL, and the sensitivity and specificity was 100.0% and 74.5%, respectively. According to maternal viral load >2 × 105 IU/mL, the sensitivity and specificity of maternal qualitative HBeAg to identify the risk of HBV MTCT for pregnant women and determine the necessity for antiviral prophylaxis was 95.5% and 92.6%, respectively. This study showed that maternal HBeAg can be a surrogate marker of HBV DNA for monitoring and evaluating whether antiviral prophylaxis is necessary for preventing perinatal HBV transmission. |
| format | Article |
| id | doaj-art-a6717a064fdf48669f97edd46bb969ce |
| institution | Kabale University |
| issn | 2222-1751 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-a6717a064fdf48669f97edd46bb969ce2025-08-20T03:52:57ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512021-01-0110155556410.1080/22221751.2021.1899055Maternal hepatitis B e antigen can be an indicator for antiviral prophylaxis of perinatal transmission of hepatitis B virusYing Lu0Yarong Song1Xiangjun Zhai2Fengcai Zhu3Jianxun Liu4Zhanjun Chang5Yi Li6Yiwei Xiao7Lili Li8Minmin Liu9Jia Liu10Zhongping Duan11Huaibin Zou12Hui Zhuang13Jie Wang14Jie Li15Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of ChinaDepartment of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of ChinaJiangsu Provincial Center for Disease Control and Prevention, Nanjing, People's Republic of ChinaJiangsu Provincial Center for Disease Control and Prevention, Nanjing, People's Republic of ChinaZhengzhou Municipal Center for Disease Control and Prevention, Zhengzhou, People's Republic of ChinaZhengzhou Municipal Center for Disease Control and Prevention, Zhengzhou, People's Republic of ChinaDepartment of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of ChinaDepartment of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of ChinaDepartment of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of ChinaDepartment of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of ChinaDepartment of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of ChinaBeijing Youan Hospital, Capital Medical University, Beijing, People's Republic of ChinaBeijing Youan Hospital, Capital Medical University, Beijing, People's Republic of ChinaDepartment of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of ChinaDepartment of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of ChinaDepartment of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of ChinaAs a high-risk factor of perinatal HBV transmission, the potential role of maternal hepatitis B e antigen (HBeAg) to guide antiviral prophylaxis has not yet been fully reported. This large prospective cohort study enrolled 1177 hepatitis B surface antigen (HBsAg)-positive pregnant women without antiviral treatment and their newborns. HBeAg, HBsAg, and viral load in maternal serum collected before delivery were measured. All the newborns were given standard passive–active immunoprophylaxis within 12 h after birth, and post-vaccination serologic testing was performed at 7 (±7d) months of age. The results revealed that 20 of the 1177 infants (1.70%) were immunoprophylaxis failure, and all their mothers were HBeAg positive. Maternal quantitative HBeAg was positively correlated with viral load (r = 0.83; P < .0001) and quantitative HBsAg (r = 0.68; P < .0001). The area under the receiver operating characteristic curve (AUC) for predicting immunoprophylaxis failure by maternal HBeAg was comparable to that by maternal viral load (0.871 vs 0.893; P = .441) and HBsAg (0.871 vs 0.871; P = .965). The optimal cutoff value of maternal quantitative HBeAg to predict perinatal infection was 2.21 log10 PEI U/mL, and the sensitivity and specificity was 100.0% and 74.5%, respectively. According to maternal viral load >2 × 105 IU/mL, the sensitivity and specificity of maternal qualitative HBeAg to identify the risk of HBV MTCT for pregnant women and determine the necessity for antiviral prophylaxis was 95.5% and 92.6%, respectively. This study showed that maternal HBeAg can be a surrogate marker of HBV DNA for monitoring and evaluating whether antiviral prophylaxis is necessary for preventing perinatal HBV transmission.https://www.tandfonline.com/doi/10.1080/22221751.2021.1899055Hepatitis B virusMother-to-child transmissionHepatitis B e antigenAntiviral prophylaxis |
| spellingShingle | Ying Lu Yarong Song Xiangjun Zhai Fengcai Zhu Jianxun Liu Zhanjun Chang Yi Li Yiwei Xiao Lili Li Minmin Liu Jia Liu Zhongping Duan Huaibin Zou Hui Zhuang Jie Wang Jie Li Maternal hepatitis B e antigen can be an indicator for antiviral prophylaxis of perinatal transmission of hepatitis B virus Emerging Microbes and Infections Hepatitis B virus Mother-to-child transmission Hepatitis B e antigen Antiviral prophylaxis |
| title | Maternal hepatitis B e antigen can be an indicator for antiviral prophylaxis of perinatal transmission of hepatitis B virus |
| title_full | Maternal hepatitis B e antigen can be an indicator for antiviral prophylaxis of perinatal transmission of hepatitis B virus |
| title_fullStr | Maternal hepatitis B e antigen can be an indicator for antiviral prophylaxis of perinatal transmission of hepatitis B virus |
| title_full_unstemmed | Maternal hepatitis B e antigen can be an indicator for antiviral prophylaxis of perinatal transmission of hepatitis B virus |
| title_short | Maternal hepatitis B e antigen can be an indicator for antiviral prophylaxis of perinatal transmission of hepatitis B virus |
| title_sort | maternal hepatitis b e antigen can be an indicator for antiviral prophylaxis of perinatal transmission of hepatitis b virus |
| topic | Hepatitis B virus Mother-to-child transmission Hepatitis B e antigen Antiviral prophylaxis |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2021.1899055 |
| work_keys_str_mv | AT yinglu maternalhepatitisbeantigencanbeanindicatorforantiviralprophylaxisofperinataltransmissionofhepatitisbvirus AT yarongsong maternalhepatitisbeantigencanbeanindicatorforantiviralprophylaxisofperinataltransmissionofhepatitisbvirus AT xiangjunzhai maternalhepatitisbeantigencanbeanindicatorforantiviralprophylaxisofperinataltransmissionofhepatitisbvirus AT fengcaizhu maternalhepatitisbeantigencanbeanindicatorforantiviralprophylaxisofperinataltransmissionofhepatitisbvirus AT jianxunliu maternalhepatitisbeantigencanbeanindicatorforantiviralprophylaxisofperinataltransmissionofhepatitisbvirus AT zhanjunchang maternalhepatitisbeantigencanbeanindicatorforantiviralprophylaxisofperinataltransmissionofhepatitisbvirus AT yili maternalhepatitisbeantigencanbeanindicatorforantiviralprophylaxisofperinataltransmissionofhepatitisbvirus AT yiweixiao maternalhepatitisbeantigencanbeanindicatorforantiviralprophylaxisofperinataltransmissionofhepatitisbvirus AT lilili maternalhepatitisbeantigencanbeanindicatorforantiviralprophylaxisofperinataltransmissionofhepatitisbvirus AT minminliu maternalhepatitisbeantigencanbeanindicatorforantiviralprophylaxisofperinataltransmissionofhepatitisbvirus AT jialiu maternalhepatitisbeantigencanbeanindicatorforantiviralprophylaxisofperinataltransmissionofhepatitisbvirus AT zhongpingduan maternalhepatitisbeantigencanbeanindicatorforantiviralprophylaxisofperinataltransmissionofhepatitisbvirus AT huaibinzou maternalhepatitisbeantigencanbeanindicatorforantiviralprophylaxisofperinataltransmissionofhepatitisbvirus AT huizhuang maternalhepatitisbeantigencanbeanindicatorforantiviralprophylaxisofperinataltransmissionofhepatitisbvirus AT jiewang maternalhepatitisbeantigencanbeanindicatorforantiviralprophylaxisofperinataltransmissionofhepatitisbvirus AT jieli maternalhepatitisbeantigencanbeanindicatorforantiviralprophylaxisofperinataltransmissionofhepatitisbvirus |