Involvement of SIRT3/FOXO1 and TLR4/NF-κB/NLRP3 pathways in protective effects of Δ(9)-tetrahydrocannabinol on diabetic cardiomyopathy in rats
Diabetic cardiomyopathy (DCM) is a chronic complication of type 2 diabetes mellitus, leading to heart failure. Addressing DCM requires a comprehensive therapeutic approach. This study examines the protective role of Δ(9)-tetrahydrocannabinol (THC) in DCM by assessing its impact on cardiac function,...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-03-01
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| Series: | Türk Biyokimya Dergisi |
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| Online Access: | https://doi.org/10.1515/tjb-2024-0258 |
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| author | Zhang Haiping Hui Xiaoli Xu Hua |
| author_facet | Zhang Haiping Hui Xiaoli Xu Hua |
| author_sort | Zhang Haiping |
| collection | DOAJ |
| description | Diabetic cardiomyopathy (DCM) is a chronic complication of type 2 diabetes mellitus, leading to heart failure. Addressing DCM requires a comprehensive therapeutic approach. This study examines the protective role of Δ(9)-tetrahydrocannabinol (THC) in DCM by assessing its impact on cardiac function, inflammation, oxidative stress, and mitochondrial health and exploring the involvement of the SIRT3/FOXO1 and TLR4/NF-κB/NLRP3 signaling pathways. |
| format | Article |
| id | doaj-art-a66d2bcdca684e37b36d470f29f46444 |
| institution | DOAJ |
| issn | 1303-829X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Türk Biyokimya Dergisi |
| spelling | doaj-art-a66d2bcdca684e37b36d470f29f464442025-08-20T03:11:07ZengDe GruyterTürk Biyokimya Dergisi1303-829X2025-03-0150230431210.1515/tjb-2024-0258Involvement of SIRT3/FOXO1 and TLR4/NF-κB/NLRP3 pathways in protective effects of Δ(9)-tetrahydrocannabinol on diabetic cardiomyopathy in ratsZhang Haiping0Hui Xiaoli1Xu Hua2Department of Disinfection Supply, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaSecond Department of Geriatric Internal Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Tumor Radiotherapy, Xi’an International Medical Center, Xi’an, ChinaDiabetic cardiomyopathy (DCM) is a chronic complication of type 2 diabetes mellitus, leading to heart failure. Addressing DCM requires a comprehensive therapeutic approach. This study examines the protective role of Δ(9)-tetrahydrocannabinol (THC) in DCM by assessing its impact on cardiac function, inflammation, oxidative stress, and mitochondrial health and exploring the involvement of the SIRT3/FOXO1 and TLR4/NF-κB/NLRP3 signaling pathways.https://doi.org/10.1515/tjb-2024-0258diabetescannabinoidmitochondriacardiomyopathyinflammationmechanism |
| spellingShingle | Zhang Haiping Hui Xiaoli Xu Hua Involvement of SIRT3/FOXO1 and TLR4/NF-κB/NLRP3 pathways in protective effects of Δ(9)-tetrahydrocannabinol on diabetic cardiomyopathy in rats Türk Biyokimya Dergisi diabetes cannabinoid mitochondria cardiomyopathy inflammation mechanism |
| title | Involvement of SIRT3/FOXO1 and TLR4/NF-κB/NLRP3 pathways in protective effects of Δ(9)-tetrahydrocannabinol on diabetic cardiomyopathy in rats |
| title_full | Involvement of SIRT3/FOXO1 and TLR4/NF-κB/NLRP3 pathways in protective effects of Δ(9)-tetrahydrocannabinol on diabetic cardiomyopathy in rats |
| title_fullStr | Involvement of SIRT3/FOXO1 and TLR4/NF-κB/NLRP3 pathways in protective effects of Δ(9)-tetrahydrocannabinol on diabetic cardiomyopathy in rats |
| title_full_unstemmed | Involvement of SIRT3/FOXO1 and TLR4/NF-κB/NLRP3 pathways in protective effects of Δ(9)-tetrahydrocannabinol on diabetic cardiomyopathy in rats |
| title_short | Involvement of SIRT3/FOXO1 and TLR4/NF-κB/NLRP3 pathways in protective effects of Δ(9)-tetrahydrocannabinol on diabetic cardiomyopathy in rats |
| title_sort | involvement of sirt3 foxo1 and tlr4 nf κb nlrp3 pathways in protective effects of δ 9 tetrahydrocannabinol on diabetic cardiomyopathy in rats |
| topic | diabetes cannabinoid mitochondria cardiomyopathy inflammation mechanism |
| url | https://doi.org/10.1515/tjb-2024-0258 |
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