Higher Circulating Lymphocytes and the Incidence of Pre-eclampsia and Eclampsia
Excessive immune activation contributes to the onset of early dysfunction of the maternal-fetal interface, and it is closely linked to the development of pre-eclampsia. However, the effect of specific immune cells on the risk of pre-eclampsia and eclampsia remains controversial. We investigated the...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2024/8834312 |
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| author | Qiuping Zhao Rongmei Liu Hui Chen Xiaomo Yang Jiajia Dong Minfu Bai MingYang Yu Zeying Feng Dingyuan Zeng |
| author_facet | Qiuping Zhao Rongmei Liu Hui Chen Xiaomo Yang Jiajia Dong Minfu Bai MingYang Yu Zeying Feng Dingyuan Zeng |
| author_sort | Qiuping Zhao |
| collection | DOAJ |
| description | Excessive immune activation contributes to the onset of early dysfunction of the maternal-fetal interface, and it is closely linked to the development of pre-eclampsia. However, the effect of specific immune cells on the risk of pre-eclampsia and eclampsia remains controversial. We investigated the causal relationship between immune cells and pre-eclampsia and eclampsia. For exposure, we extracted genetic variants associated with immune cell-related traits, and for outcomes, we used summary genetic data of pre-eclampsia/eclampsia. A two-sample Mendelian randomization (MR) analysis was then performed to assess the causal relationship. Robustness of the MR results was then evaluated through colocalization analysis. We found that genetically proxied circulating lymphocyte absolute count was causally associated with total eclampsia (odds ratio OR=1.53, 95% confidence interval (CI) (1.31-1.79), p=1.15E−07) and pre-eclampsia (OR=1.50, 95% CI (1.28-1.77), p=9.18E−07); T cell absolute count was causally associated with total eclampsia (OR=1.49, 95% CI (1.28-1.73), p=2.73E−07) and pre-eclampsia (OR=1.47, 95% CI (1.25-1.72), p=1.76E−06). And CD28- CD25+ CD8+ T cell absolute count was causally associated with total eclampsia (OR=1.83, 95% CI (1.44-2.32), p=7.11E−07) and pre-eclampsia (OR=1.77, 95% CI (1.38-2.26), p=6.55E−06). Colocalization analysis revealed that immune cell-related traits shared the same variant with pre-eclampsia/eclampsia. Our study suggested causal effects of genetic predisposition to high lymphocyte absolute count levels, T cell absolute count, and CD28- CD25+ CD8+ T cell absolute count on eclampsia, particularly pre-eclampsia risk, providing crucial new insights into the potential prevention target for eclampsia and pre-eclampsia. |
| format | Article |
| id | doaj-art-a6678abc0117475fbf3379fdc15216df |
| institution | OA Journals |
| issn | 2090-2735 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-a6678abc0117475fbf3379fdc15216df2025-08-20T02:20:49ZengWileyJournal of Pregnancy2090-27352024-01-01202410.1155/2024/8834312Higher Circulating Lymphocytes and the Incidence of Pre-eclampsia and EclampsiaQiuping Zhao0Rongmei Liu1Hui Chen2Xiaomo Yang3Jiajia Dong4Minfu Bai5MingYang Yu6Zeying Feng7Dingyuan Zeng8Fuwai Central China Cardiovascular HospitalFuwai Central China Cardiovascular HospitalFuwai Central China Cardiovascular HospitalFuwai Central China Cardiovascular HospitalFuwai Central China Cardiovascular HospitalFuwai Central China Cardiovascular HospitalFuwai Central China Cardiovascular HospitalDepartment of Gynecology and ObstetricsDepartment of Gynecology and ObstetricsExcessive immune activation contributes to the onset of early dysfunction of the maternal-fetal interface, and it is closely linked to the development of pre-eclampsia. However, the effect of specific immune cells on the risk of pre-eclampsia and eclampsia remains controversial. We investigated the causal relationship between immune cells and pre-eclampsia and eclampsia. For exposure, we extracted genetic variants associated with immune cell-related traits, and for outcomes, we used summary genetic data of pre-eclampsia/eclampsia. A two-sample Mendelian randomization (MR) analysis was then performed to assess the causal relationship. Robustness of the MR results was then evaluated through colocalization analysis. We found that genetically proxied circulating lymphocyte absolute count was causally associated with total eclampsia (odds ratio OR=1.53, 95% confidence interval (CI) (1.31-1.79), p=1.15E−07) and pre-eclampsia (OR=1.50, 95% CI (1.28-1.77), p=9.18E−07); T cell absolute count was causally associated with total eclampsia (OR=1.49, 95% CI (1.28-1.73), p=2.73E−07) and pre-eclampsia (OR=1.47, 95% CI (1.25-1.72), p=1.76E−06). And CD28- CD25+ CD8+ T cell absolute count was causally associated with total eclampsia (OR=1.83, 95% CI (1.44-2.32), p=7.11E−07) and pre-eclampsia (OR=1.77, 95% CI (1.38-2.26), p=6.55E−06). Colocalization analysis revealed that immune cell-related traits shared the same variant with pre-eclampsia/eclampsia. Our study suggested causal effects of genetic predisposition to high lymphocyte absolute count levels, T cell absolute count, and CD28- CD25+ CD8+ T cell absolute count on eclampsia, particularly pre-eclampsia risk, providing crucial new insights into the potential prevention target for eclampsia and pre-eclampsia.http://dx.doi.org/10.1155/2024/8834312 |
| spellingShingle | Qiuping Zhao Rongmei Liu Hui Chen Xiaomo Yang Jiajia Dong Minfu Bai MingYang Yu Zeying Feng Dingyuan Zeng Higher Circulating Lymphocytes and the Incidence of Pre-eclampsia and Eclampsia Journal of Pregnancy |
| title | Higher Circulating Lymphocytes and the Incidence of Pre-eclampsia and Eclampsia |
| title_full | Higher Circulating Lymphocytes and the Incidence of Pre-eclampsia and Eclampsia |
| title_fullStr | Higher Circulating Lymphocytes and the Incidence of Pre-eclampsia and Eclampsia |
| title_full_unstemmed | Higher Circulating Lymphocytes and the Incidence of Pre-eclampsia and Eclampsia |
| title_short | Higher Circulating Lymphocytes and the Incidence of Pre-eclampsia and Eclampsia |
| title_sort | higher circulating lymphocytes and the incidence of pre eclampsia and eclampsia |
| url | http://dx.doi.org/10.1155/2024/8834312 |
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