Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression.

Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression.

Infection with high-risk human papillomavirus (HPV) type 16 is an independent risk factor for the development of oropharyngeal squamous cell carcinomas (OSCC). However, it is unclear whether viral integration is an essential hallmark in the carcinogenic process of OSCC and whether HPV integration co...

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Main Authors: Nadine C Olthof, Ernst-Jan M Speel, Jutta Kolligs, Annick Haesevoets, Mieke Henfling, Frans C S Ramaekers, Simon F Preuss, Uta Drebber, Ulrike Wieland, Steffi Silling, Wan L Lam, Emily A Vucic, Bernd Kremer, Jens-P Klussmann, Christian U Huebbers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0088718&type=printable
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