Salvianic acid A promotes osteogenic differentiation of bone marrow mesenchymal stem cells in senile osteoporosis through bromodomain-containing protein 4/Ariadne RBR E3 ubiquitin-protein ligase 1/Rubicon axis

Salvianic acid A promotes osteogenic differentiation of bone marrow mesenchymal stem cells in senile osteoporosis through bromodomain-containing protein 4/Ariadne RBR E3 ubiquitin-protein ligase 1/Rubicon axis

Background: Senile osteoporosis (SOP) seriously disturbs the life of elder people. Inhibition of autophagy can contribute to the progression of SOP. Meanwhile, Salvianic acid A (SA) could inhibit the progression of SOP, and it could regulate the autophagy. However, the relationship between SA and au...

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Bibliographic Details
Main Authors: Zhixian Xu, Jun Luo, Yongfa Zhang, Zhenyu Zhang, Jie Xu
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Traditional and Complementary Medicine
Subjects:
Senile osteoporosis
Salvianic acid A
Autophagy
BRD4/ARIH1/Rubicon axis
Online Access:http://www.sciencedirect.com/science/article/pii/S2225411025000136
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