Zebrafish ambra1a and ambra1b knockdown impairs skeletal muscle development.

Zebrafish ambra1a and ambra1b knockdown impairs skeletal muscle development.

The essential role of autophagy in muscle homeostasis has been clearly demonstrated by phenotype analysis of mice with muscle-specific inactivation of genes encoding autophagy-related proteins. Ambra1 is a key component of the Beclin 1 complex and, in zebrafish, it is encoded by two paralogous genes...

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Main Authors: Tatjana Skobo, Francesca Benato, Paolo Grumati, Giacomo Meneghetti, Valentina Cianfanelli, Silvia Castagnaro, Martina Chrisam, Sabrina Di Bartolomeo, Paolo Bonaldo, Francesco Cecconi, Luisa Dalla Valle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0099210
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