18F-MK-6240 tau PET in patients at-risk for chronic traumatic encephalopathy

18F-MK-6240 tau PET in patients at-risk for chronic traumatic encephalopathy

Abstract Background Molecular biomarkers of chronic traumatic encephalopathy (CTE) are lacking. We evaluated 18F-MK-6240 tau PET as a biomarker for CTE. Two studies were done: (1) 3H-MK-6240 autoradiography and an in-vitro brain homogenate binding studies on postmortem CTE tissue, (2) an in-vivo 18F...

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Main Authors: Michael L. Alosco, Jhony Mejía Pérez, Julia E. Culhane, Ranjani Shankar, Christopher J. Nowinski, Samantha Bureau, Nidhi Mundada, Karen Smith, Alinda Amuiri, Breton Asken, Jenna R. Groh, Annalise Miner, Erika Pettway, Sydney Mosaheb, Yorghos Tripodis, Charles Windon, Gustavo Mercier, Robert A. Stern, Lea T. Grinberg, David N. Soleimani-Meigooni, Bradley T. Christian, Tobey J. Betthauser, Thor D. Stein, Ann C. McKee, Chester A. Mathis, Eric E. Abrahamson, Milos D. Ikonomovic, Sterling C. Johnson, Jesse Mez, Renaud La Joie, Daniel Schonhaut, Gil D. Rabinovici
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Biomarkers
Chronic traumatic encephalopathy
MK-6240
Repetitive head impacts
Tau PET
Online Access:https://doi.org/10.1186/s13024-025-00808-1
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