Vitamin D deficiency, fatigue, and persistent cough as independent predictors of depressive symptoms in sarcoidosis patients
Background: Depressive symptoms are frequent in sarcoidosis. We assessed the impact of sarcoidosis symptoms, pulmonary function, fatigue, radiographic findings, comorbidities, treatment, and serum levels of 25-hydroxyvitamin D (25(OH)D) on depressive symptoms in sarcoidosis patients. Methods: In a c...
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Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582503495G.pdf |
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| author | Gvozdenovic Branislav S. Mihailovic-Vucinic Violeta Vukovic Mira Omcikus Maja Cvejic Jelena Belic Slobodan Jankovic Jelena Đurđevic Natasa Stjepanovic Mihailo |
| author_facet | Gvozdenovic Branislav S. Mihailovic-Vucinic Violeta Vukovic Mira Omcikus Maja Cvejic Jelena Belic Slobodan Jankovic Jelena Đurđevic Natasa Stjepanovic Mihailo |
| author_sort | Gvozdenovic Branislav S. |
| collection | DOAJ |
| description | Background: Depressive symptoms are frequent in sarcoidosis. We assessed the impact of sarcoidosis symptoms, pulmonary function, fatigue, radiographic findings, comorbidities, treatment, and serum levels of 25-hydroxyvitamin D (25(OH)D) on depressive symptoms in sarcoidosis patients. Methods: In a cross-sectional study, we measured depressive symptoms using the Center for Epidemiologic Studies - Depression Scale (CES-D) and fatigue using the Fatigue Assessment Scale (FAS). Presence of depressive symptoms was defined with CES-D scores ≥16 and ≥20, respectively. Fatigue was defined as having an FAS score of ≥22. Results: A total of 400 patients were included in the study. CES-D score ≥16 had 128 patients, while CES-D score ≥20 had 86 patients. In a multivariate binomial logistic regression model, the following independent predictors of CES-D score ≥16 were identified: female gender (odds ratio, OR 1.983), chronic sarcoidosis (OR 2.311), serum levels of 25(OH)D ≤20 ng/mL (OR 2.326), persistent dry cough (OR 2.173), FAS Scores ≥22 (OR 9.243), and chest X-ray stage 3 (8.851). Five variables were independent predictors of CES-D score ≥20: diplopia (OR 4.411), FEV1 <80% predicted associated with FVC <80% predicted (OR 2.311), serum levels of 25(OH)D ≤20 ng/mL (OR 2.278), persistent dry cough (OR 3.001), and FAS Scores ≥22 (OR 7.611). Conclusions: Measuring the contribution of low serum 25-hydroxyvitamin D and the impact of persistent dry cough on depressive symptoms in patients with sarcoidosis may be crucial in deciding whether to use vitamin D3 alone or with antitussive therapy before the psychiatric diagnosis of depression with antidepressant therapy initiation. |
| format | Article |
| id | doaj-art-a66003026ccd43a8bf38dc49bbc5712d |
| institution | DOAJ |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj-art-a66003026ccd43a8bf38dc49bbc5712d2025-08-20T02:44:38ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-0144349550610.5937/jomb0-540151452-82582503495GVitamin D deficiency, fatigue, and persistent cough as independent predictors of depressive symptoms in sarcoidosis patientsGvozdenovic Branislav S.0Mihailovic-Vucinic Violeta1Vukovic Mira2https://orcid.org/0000-0002-3662-5374Omcikus Maja3Cvejic Jelena4Belic Slobodan5Jankovic Jelena6https://orcid.org/0000-0001-8529-8624Đurđevic Natasa7Stjepanovic Mihailo8https://orcid.org/0000-0003-1787-1438PPD Serbia, Part of Thermo Fisher Scientific, Pharmacovigilance Department, Belgrade, SerbiaMediGroup General Hospital, Belgrade, Serbia, SerbiaHealth Center Valjevo, QA Department, SerbiaUniversity of Belgrade, School of Medicine, Belgrade, Serbia, SerbiaUniversity Clinical Center of Serbia, Clinic for Pulmonary Diseases, Belgrade, SerbiaUniversity of Belgrade, School of Medicine, Belgrade, Serbia, SerbiaUniversity of Belgrade, School of Medicine, Belgrade, Serbia, SerbiaUniversity of Belgrade, School of Medicine, Belgrade, Serbia, SerbiaUniversity of Belgrade, School of Medicine, Belgrade, Serbia, SerbiaBackground: Depressive symptoms are frequent in sarcoidosis. We assessed the impact of sarcoidosis symptoms, pulmonary function, fatigue, radiographic findings, comorbidities, treatment, and serum levels of 25-hydroxyvitamin D (25(OH)D) on depressive symptoms in sarcoidosis patients. Methods: In a cross-sectional study, we measured depressive symptoms using the Center for Epidemiologic Studies - Depression Scale (CES-D) and fatigue using the Fatigue Assessment Scale (FAS). Presence of depressive symptoms was defined with CES-D scores ≥16 and ≥20, respectively. Fatigue was defined as having an FAS score of ≥22. Results: A total of 400 patients were included in the study. CES-D score ≥16 had 128 patients, while CES-D score ≥20 had 86 patients. In a multivariate binomial logistic regression model, the following independent predictors of CES-D score ≥16 were identified: female gender (odds ratio, OR 1.983), chronic sarcoidosis (OR 2.311), serum levels of 25(OH)D ≤20 ng/mL (OR 2.326), persistent dry cough (OR 2.173), FAS Scores ≥22 (OR 9.243), and chest X-ray stage 3 (8.851). Five variables were independent predictors of CES-D score ≥20: diplopia (OR 4.411), FEV1 <80% predicted associated with FVC <80% predicted (OR 2.311), serum levels of 25(OH)D ≤20 ng/mL (OR 2.278), persistent dry cough (OR 3.001), and FAS Scores ≥22 (OR 7.611). Conclusions: Measuring the contribution of low serum 25-hydroxyvitamin D and the impact of persistent dry cough on depressive symptoms in patients with sarcoidosis may be crucial in deciding whether to use vitamin D3 alone or with antitussive therapy before the psychiatric diagnosis of depression with antidepressant therapy initiation.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582503495G.pdfsarcoidosisdepressive symptomsvitamin d deficiencyfatiguecoughmultivariate analysis |
| spellingShingle | Gvozdenovic Branislav S. Mihailovic-Vucinic Violeta Vukovic Mira Omcikus Maja Cvejic Jelena Belic Slobodan Jankovic Jelena Đurđevic Natasa Stjepanovic Mihailo Vitamin D deficiency, fatigue, and persistent cough as independent predictors of depressive symptoms in sarcoidosis patients Journal of Medical Biochemistry sarcoidosis depressive symptoms vitamin d deficiency fatigue cough multivariate analysis |
| title | Vitamin D deficiency, fatigue, and persistent cough as independent predictors of depressive symptoms in sarcoidosis patients |
| title_full | Vitamin D deficiency, fatigue, and persistent cough as independent predictors of depressive symptoms in sarcoidosis patients |
| title_fullStr | Vitamin D deficiency, fatigue, and persistent cough as independent predictors of depressive symptoms in sarcoidosis patients |
| title_full_unstemmed | Vitamin D deficiency, fatigue, and persistent cough as independent predictors of depressive symptoms in sarcoidosis patients |
| title_short | Vitamin D deficiency, fatigue, and persistent cough as independent predictors of depressive symptoms in sarcoidosis patients |
| title_sort | vitamin d deficiency fatigue and persistent cough as independent predictors of depressive symptoms in sarcoidosis patients |
| topic | sarcoidosis depressive symptoms vitamin d deficiency fatigue cough multivariate analysis |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582503495G.pdf |
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