Adult Onset Still’s Disease: A Review on Diagnostic Workup and Treatment Options

Adult onset Still’s disease (AOSD) is a rare systemic inflammatory disease of unknown etiology and pathogenesis that presents in 5 to 10% of patients as fever of unknown origin (FUO) accompanied by systemic manifestations. We report an interesting case of a 33-year-old African-American male who pres...

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Main Authors: Rajesh Gopalarathinam, Eric Orlowsky, Ramesh Kesavalu, Sreeteja Yelaminchili
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Case Reports in Rheumatology
Online Access:http://dx.doi.org/10.1155/2016/6502373
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author Rajesh Gopalarathinam
Eric Orlowsky
Ramesh Kesavalu
Sreeteja Yelaminchili
author_facet Rajesh Gopalarathinam
Eric Orlowsky
Ramesh Kesavalu
Sreeteja Yelaminchili
author_sort Rajesh Gopalarathinam
collection DOAJ
description Adult onset Still’s disease (AOSD) is a rare systemic inflammatory disease of unknown etiology and pathogenesis that presents in 5 to 10% of patients as fever of unknown origin (FUO) accompanied by systemic manifestations. We report an interesting case of a 33-year-old African-American male who presented with one-month duration of FUO along with skin rash, sore throat, and arthralgia. After extensive workup, potential differential diagnoses were ruled out and the patient was diagnosed with AOSD based on the Yamaguchi criteria. The case history, incidence, pathogenesis, clinical manifestations, differential diagnoses, diagnostic workup, treatment modalities, and prognosis of AOSD are discussed in this case report.
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spelling doaj-art-a65700f685fb489d82f32fffd9d5a1712025-08-20T02:20:49ZengWileyCase Reports in Rheumatology2090-68892090-68972016-01-01201610.1155/2016/65023736502373Adult Onset Still’s Disease: A Review on Diagnostic Workup and Treatment OptionsRajesh Gopalarathinam0Eric Orlowsky1Ramesh Kesavalu2Sreeteja Yelaminchili3Department of Internal Medicine, Allegheny General Hospital, 320 E. North Avenue, Pittsburgh, PA 15212, USADepartment of Rheumatology, Allegheny General Hospital, 320 E. North Avenue, Pittsburgh, PA 15212, USADepartment of Rheumatology, Lakeside Community Healthcare Medical Group, 1500 S. Central Avenue No. 200, Glendale, CA 91204, USADepartment of Internal Medicine, Capital Health Regional Medical Center, 750 Brunswick Avenue, Trenton, NJ 08638, USAAdult onset Still’s disease (AOSD) is a rare systemic inflammatory disease of unknown etiology and pathogenesis that presents in 5 to 10% of patients as fever of unknown origin (FUO) accompanied by systemic manifestations. We report an interesting case of a 33-year-old African-American male who presented with one-month duration of FUO along with skin rash, sore throat, and arthralgia. After extensive workup, potential differential diagnoses were ruled out and the patient was diagnosed with AOSD based on the Yamaguchi criteria. The case history, incidence, pathogenesis, clinical manifestations, differential diagnoses, diagnostic workup, treatment modalities, and prognosis of AOSD are discussed in this case report.http://dx.doi.org/10.1155/2016/6502373
spellingShingle Rajesh Gopalarathinam
Eric Orlowsky
Ramesh Kesavalu
Sreeteja Yelaminchili
Adult Onset Still’s Disease: A Review on Diagnostic Workup and Treatment Options
Case Reports in Rheumatology
title Adult Onset Still’s Disease: A Review on Diagnostic Workup and Treatment Options
title_full Adult Onset Still’s Disease: A Review on Diagnostic Workup and Treatment Options
title_fullStr Adult Onset Still’s Disease: A Review on Diagnostic Workup and Treatment Options
title_full_unstemmed Adult Onset Still’s Disease: A Review on Diagnostic Workup and Treatment Options
title_short Adult Onset Still’s Disease: A Review on Diagnostic Workup and Treatment Options
title_sort adult onset still s disease a review on diagnostic workup and treatment options
url http://dx.doi.org/10.1155/2016/6502373
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