Novel multiple Z-score models for detection of coronary artery dilation: application in Kawasaki disease
Abstract Background This study aims to develop Z-Score models to normalize measurements of three coronary arteries and enhance the diagnosis of Kawasaki disease (KD) in children from newborns to 10 years old. Developing a reliable Z-Score model is challenging, as some existing models fail the normal...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Pediatric Rheumatology Online Journal |
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| Online Access: | https://doi.org/10.1186/s12969-024-01040-9 |
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| author | Ho-Chang Kuo Shih-Hsin Chen I-Fei Chen Wen-Ing Cheng Shih-Feng Liu Mindy Ming-Huey Guo Yu-Chi Lin Yi-Hui Chen |
| author_facet | Ho-Chang Kuo Shih-Hsin Chen I-Fei Chen Wen-Ing Cheng Shih-Feng Liu Mindy Ming-Huey Guo Yu-Chi Lin Yi-Hui Chen |
| author_sort | Ho-Chang Kuo |
| collection | DOAJ |
| description | Abstract Background This study aims to develop Z-Score models to normalize measurements of three coronary arteries and enhance the diagnosis of Kawasaki disease (KD) in children from newborns to 10 years old. Developing a reliable Z-Score model is challenging, as some existing models fail the normality test. Overcoming these challenges is crucial for improving KD diagnosis. Method Detailed measurements of the left main coronary artery (LCA), left anterior descending coronary artery (LAD), and right coronary artery (RCA) were collected, along with patient demographics such as age, height, weight, and body surface area (BSA). Several Z-Score models, named the Kuo Z-Score models, were proposed, with separate designs for different coronary arteries and different age groups, resulting in multiple Z-Score models. The Z-Score model for the RCA employs the Box-Cox method for data transformation. Finally, we tested various age group combinations, selecting models that passed the Anderson–Darling normality test and had higher R-square values for robustness and best data fit. Results The study included 1180 participants free from coronary or heart diseases. The Kuo Z-Score models were optimized for LCA, LAD, and RCA across the five age groups 0–6 years, 6–7 years, 7–8 years, 8–9 years, and 9–10 years. Only the normality test for the RCA in the 7–8 year age group failed. The proposed model fitted to the normality assumption outperforming the other models. Conclusion The Kuo Z-Score models, applicable across a broad age range, provides robust identification of coronary artery dilatation and aneurysm in KD. The models’ capability to normalize diverse data sets marks a significant advancement in KD diagnostic sensitivity, aiding in better clinical decision-making and potentially improving patient outcomes. |
| format | Article |
| id | doaj-art-a6491a3e714844c8957f992ecb985105 |
| institution | OA Journals |
| issn | 1546-0096 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Pediatric Rheumatology Online Journal |
| spelling | doaj-art-a6491a3e714844c8957f992ecb9851052025-08-20T02:31:41ZengBMCPediatric Rheumatology Online Journal1546-00962024-12-0122111010.1186/s12969-024-01040-9Novel multiple Z-score models for detection of coronary artery dilation: application in Kawasaki diseaseHo-Chang Kuo0Shih-Hsin Chen1I-Fei Chen2Wen-Ing Cheng3Shih-Feng Liu4Mindy Ming-Huey Guo5Yu-Chi Lin6Yi-Hui Chen7Department of Pediatrics, Kaohsiung Chang Gung Memorial HospitalDepartment of Computer Science and Information Engineering, Tamkang UniversityDepartment of Management Sciences, Tamkang UniversityDepartment of Management Sciences, Tamkang UniversityDepartment of Respiratory Therapy, Kaohsiung Chang Gung Memorial HospitalDepartment of Pediatrics, Kaohsiung Chang Gung Memorial HospitalKawasaki Disease Center, Kaohsiung Chang Gung Memorial HospitalKawasaki Disease Center, Kaohsiung Chang Gung Memorial HospitalAbstract Background This study aims to develop Z-Score models to normalize measurements of three coronary arteries and enhance the diagnosis of Kawasaki disease (KD) in children from newborns to 10 years old. Developing a reliable Z-Score model is challenging, as some existing models fail the normality test. Overcoming these challenges is crucial for improving KD diagnosis. Method Detailed measurements of the left main coronary artery (LCA), left anterior descending coronary artery (LAD), and right coronary artery (RCA) were collected, along with patient demographics such as age, height, weight, and body surface area (BSA). Several Z-Score models, named the Kuo Z-Score models, were proposed, with separate designs for different coronary arteries and different age groups, resulting in multiple Z-Score models. The Z-Score model for the RCA employs the Box-Cox method for data transformation. Finally, we tested various age group combinations, selecting models that passed the Anderson–Darling normality test and had higher R-square values for robustness and best data fit. Results The study included 1180 participants free from coronary or heart diseases. The Kuo Z-Score models were optimized for LCA, LAD, and RCA across the five age groups 0–6 years, 6–7 years, 7–8 years, 8–9 years, and 9–10 years. Only the normality test for the RCA in the 7–8 year age group failed. The proposed model fitted to the normality assumption outperforming the other models. Conclusion The Kuo Z-Score models, applicable across a broad age range, provides robust identification of coronary artery dilatation and aneurysm in KD. The models’ capability to normalize diverse data sets marks a significant advancement in KD diagnostic sensitivity, aiding in better clinical decision-making and potentially improving patient outcomes.https://doi.org/10.1186/s12969-024-01040-9Kawasaki diseaseZ-ScoreNormality TestBox-Cox Transformation |
| spellingShingle | Ho-Chang Kuo Shih-Hsin Chen I-Fei Chen Wen-Ing Cheng Shih-Feng Liu Mindy Ming-Huey Guo Yu-Chi Lin Yi-Hui Chen Novel multiple Z-score models for detection of coronary artery dilation: application in Kawasaki disease Pediatric Rheumatology Online Journal Kawasaki disease Z-Score Normality Test Box-Cox Transformation |
| title | Novel multiple Z-score models for detection of coronary artery dilation: application in Kawasaki disease |
| title_full | Novel multiple Z-score models for detection of coronary artery dilation: application in Kawasaki disease |
| title_fullStr | Novel multiple Z-score models for detection of coronary artery dilation: application in Kawasaki disease |
| title_full_unstemmed | Novel multiple Z-score models for detection of coronary artery dilation: application in Kawasaki disease |
| title_short | Novel multiple Z-score models for detection of coronary artery dilation: application in Kawasaki disease |
| title_sort | novel multiple z score models for detection of coronary artery dilation application in kawasaki disease |
| topic | Kawasaki disease Z-Score Normality Test Box-Cox Transformation |
| url | https://doi.org/10.1186/s12969-024-01040-9 |
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