Effects of a novel differential diagnosis aid for managing patients with unexplained fatigue in primary care: a prospective randomized, controlled, open and multicenter study in primary care

Abstract Aims of the study Unexplained fatigue is a common reason for encounters in primary care. However, currently no aid orients physicians in detecting its potential causes. The aim of this study was to evaluate whether the novel Fatigue Differential Diagnostic Aid (FDDA) supported clinicians in...

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Main Authors: Roland von Känel, Stefan Neuner-Jehle, Reto W. Kressig, Idris Guessous, Pierre Alexandre Krayenbühl, Lukas Zimmerli, Anne Angelilo-Scherer, Thomas Keller, Caroline Elzner, Karl Pauls, Neige Morin, Edouard Battegay
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Language:English
Published: BMC 2025-05-01
Series:BMC Primary Care
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Online Access:https://doi.org/10.1186/s12875-025-02873-3
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author Roland von Känel
Stefan Neuner-Jehle
Reto W. Kressig
Idris Guessous
Pierre Alexandre Krayenbühl
Lukas Zimmerli
Anne Angelilo-Scherer
Thomas Keller
Caroline Elzner
Karl Pauls
Neige Morin
Edouard Battegay
author_facet Roland von Känel
Stefan Neuner-Jehle
Reto W. Kressig
Idris Guessous
Pierre Alexandre Krayenbühl
Lukas Zimmerli
Anne Angelilo-Scherer
Thomas Keller
Caroline Elzner
Karl Pauls
Neige Morin
Edouard Battegay
author_sort Roland von Känel
collection DOAJ
description Abstract Aims of the study Unexplained fatigue is a common reason for encounters in primary care. However, currently no aid orients physicians in detecting its potential causes. The aim of this study was to evaluate whether the novel Fatigue Differential Diagnostic Aid (FDDA) supported clinicians in better managing unexplained fatigue. Methods This was a prospective, cluster-randomized, controlled, open, and multicenter study comparing the use of the FDDA vs usual care in patients with unexplained fatigue as the main reason for encounter. The primary endpoint was difference in Patient Global Impression of Change (PGIC) between groups at 3 months. Among pre-defined secondary endpoints were: Difference in change of PGIC between groups at 6 months; percentage of patients with fatigue reduction; mean reduction in fatigue; clinician’s confidence in diagnosis; patient satisfaction with quality of care (diagnostic process and treatment); number of clinician-reported visits; number of referrals to specialists; and time until final diagnosis. Results 112 primary care practitioners (PCPs) recruited in Switzerland between 2017 to 2020 were randomly cluster-assigned to the FDDA = 57 or usual care = 55 arm. Of these, 15 (FDDA) and 22 (usual care) PCPs recruited 93 patients (FDDA: n = 40, usual care: n = 53). The achieved sample size was less than planned. There was no difference in PGIC at 3 months between groups (D = 0.06, 95%-CI: -0.41 – -0.53, p = 0.802). Among secondary endpoints, no significant differences occurred in PGIC at 6 months, nor in fatigue reduction. However, in the FDDA group, more patients reported less fatigue at 3 or 6 months (D = 18.9%, 95%-CI: -33.6 – -4.3%, p = 0.011), and increased satisfaction with treatment management at 1 month (FDDA 56.8% vs usual care 25.0%, p = 0.004) and 3 months (FDDA 64.9% vs usual care 31.0%, p = 0.003); the FDDA was also associated with higher total number of visits (median 4.0 vs 3.0, p < 0.001). Conclusions In this pilot study, the FDDA, a structured diagnostic aid for guiding PCPs in identifying the causes of unexplained fatigue in their patients, was not able to show a global improvement in patient outcomes despite improvements in fatigue and satisfaction with care. The evaluation of fatigue in larger-scale studies is warranted. Trial registration This trial was retrospectively registered on ClinicalTrials.gov. Trial registration number: NCT05861492. Date of registration: 17th May 2023. The ethics committee of Ethikkommission Nordwest- und Zentralschweiz (EKNZ) had originally voiced the opinion that no registration was required because no drug or intervention was involved, i.e., the study was non-interventional and observational. However, the study authors felt that the study should be retrospectively registered because the FDDA could be interpreted to be an active intervention. At the time of registration, two protocol deviations occurred that are explicitly addressed in the Methods section of this manuscript. Because of the low sample size, we statistically compared “patients” instead of “comparing patients nested in doctors” (the latter was performed as an additional analysis). Thus, cluster randomization was performed, but the analysis to consider this was not feasible.
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spelling doaj-art-a648e0749c8345b98aa0e7af4f1f8d422025-08-20T01:53:14ZengBMCBMC Primary Care2731-45532025-05-0126111010.1186/s12875-025-02873-3Effects of a novel differential diagnosis aid for managing patients with unexplained fatigue in primary care: a prospective randomized, controlled, open and multicenter study in primary careRoland von Känel0Stefan Neuner-Jehle1Reto W. Kressig2Idris Guessous3Pierre Alexandre Krayenbühl4Lukas Zimmerli5Anne Angelilo-Scherer6Thomas Keller7Caroline Elzner8Karl Pauls9Neige Morin10Edouard Battegay11Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of ZurichInstitute of Primary Care, University of Zurich and University Hospital of ZurichUniversity Department of Geriatric Medicine Felix Platter &, University of BaselUnit of Population Epidemiology, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University HospitalsGeneral PracticeDepartment of Internal Medicine, Cantonal Hospital Olten, Solothurner Spitäler AGDepartment of Haematology and Central Haematology Laboratory, University Insel Hospital, Bern, and Medical Faculty, Basel UniversityACOMED StatistikACOMED StatistikBerlin Center for Epidemiology and Health Research, ZEGMedical Affairs Department, CSL ViforInternational Center for Multimorbidity and Complexity in Medicine (ICMC), UZH Longevity Center, University of Zurich, Merian Iselin KlinikAbstract Aims of the study Unexplained fatigue is a common reason for encounters in primary care. However, currently no aid orients physicians in detecting its potential causes. The aim of this study was to evaluate whether the novel Fatigue Differential Diagnostic Aid (FDDA) supported clinicians in better managing unexplained fatigue. Methods This was a prospective, cluster-randomized, controlled, open, and multicenter study comparing the use of the FDDA vs usual care in patients with unexplained fatigue as the main reason for encounter. The primary endpoint was difference in Patient Global Impression of Change (PGIC) between groups at 3 months. Among pre-defined secondary endpoints were: Difference in change of PGIC between groups at 6 months; percentage of patients with fatigue reduction; mean reduction in fatigue; clinician’s confidence in diagnosis; patient satisfaction with quality of care (diagnostic process and treatment); number of clinician-reported visits; number of referrals to specialists; and time until final diagnosis. Results 112 primary care practitioners (PCPs) recruited in Switzerland between 2017 to 2020 were randomly cluster-assigned to the FDDA = 57 or usual care = 55 arm. Of these, 15 (FDDA) and 22 (usual care) PCPs recruited 93 patients (FDDA: n = 40, usual care: n = 53). The achieved sample size was less than planned. There was no difference in PGIC at 3 months between groups (D = 0.06, 95%-CI: -0.41 – -0.53, p = 0.802). Among secondary endpoints, no significant differences occurred in PGIC at 6 months, nor in fatigue reduction. However, in the FDDA group, more patients reported less fatigue at 3 or 6 months (D = 18.9%, 95%-CI: -33.6 – -4.3%, p = 0.011), and increased satisfaction with treatment management at 1 month (FDDA 56.8% vs usual care 25.0%, p = 0.004) and 3 months (FDDA 64.9% vs usual care 31.0%, p = 0.003); the FDDA was also associated with higher total number of visits (median 4.0 vs 3.0, p < 0.001). Conclusions In this pilot study, the FDDA, a structured diagnostic aid for guiding PCPs in identifying the causes of unexplained fatigue in their patients, was not able to show a global improvement in patient outcomes despite improvements in fatigue and satisfaction with care. The evaluation of fatigue in larger-scale studies is warranted. Trial registration This trial was retrospectively registered on ClinicalTrials.gov. Trial registration number: NCT05861492. Date of registration: 17th May 2023. The ethics committee of Ethikkommission Nordwest- und Zentralschweiz (EKNZ) had originally voiced the opinion that no registration was required because no drug or intervention was involved, i.e., the study was non-interventional and observational. However, the study authors felt that the study should be retrospectively registered because the FDDA could be interpreted to be an active intervention. At the time of registration, two protocol deviations occurred that are explicitly addressed in the Methods section of this manuscript. Because of the low sample size, we statistically compared “patients” instead of “comparing patients nested in doctors” (the latter was performed as an additional analysis). Thus, cluster randomization was performed, but the analysis to consider this was not feasible.https://doi.org/10.1186/s12875-025-02873-3FatigueDifferential diagnosisTreatment outcomePatient relevant outcomePatient satisfactionPrimary care
spellingShingle Roland von Känel
Stefan Neuner-Jehle
Reto W. Kressig
Idris Guessous
Pierre Alexandre Krayenbühl
Lukas Zimmerli
Anne Angelilo-Scherer
Thomas Keller
Caroline Elzner
Karl Pauls
Neige Morin
Edouard Battegay
Effects of a novel differential diagnosis aid for managing patients with unexplained fatigue in primary care: a prospective randomized, controlled, open and multicenter study in primary care
BMC Primary Care
Fatigue
Differential diagnosis
Treatment outcome
Patient relevant outcome
Patient satisfaction
Primary care
title Effects of a novel differential diagnosis aid for managing patients with unexplained fatigue in primary care: a prospective randomized, controlled, open and multicenter study in primary care
title_full Effects of a novel differential diagnosis aid for managing patients with unexplained fatigue in primary care: a prospective randomized, controlled, open and multicenter study in primary care
title_fullStr Effects of a novel differential diagnosis aid for managing patients with unexplained fatigue in primary care: a prospective randomized, controlled, open and multicenter study in primary care
title_full_unstemmed Effects of a novel differential diagnosis aid for managing patients with unexplained fatigue in primary care: a prospective randomized, controlled, open and multicenter study in primary care
title_short Effects of a novel differential diagnosis aid for managing patients with unexplained fatigue in primary care: a prospective randomized, controlled, open and multicenter study in primary care
title_sort effects of a novel differential diagnosis aid for managing patients with unexplained fatigue in primary care a prospective randomized controlled open and multicenter study in primary care
topic Fatigue
Differential diagnosis
Treatment outcome
Patient relevant outcome
Patient satisfaction
Primary care
url https://doi.org/10.1186/s12875-025-02873-3
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