Rapid Remission in Peripheral T-Cell Lymphoma of the Nasal Type by the Bortezomib plus CHOP Therapy
Peripheral T-cell lymphoma (PTCL) is rare and difficult to treat for its high relapse rate. The authors report a case of PTCL of the skin, regarding which clinical and pathological features, treatment, and prognosis were discussed. A 66-year-old woman was admitted with complaints of enlarging erythe...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2010/403237 |
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| author | Li-Jun Xue Xiao-Bei Mao Xiao-Bei Liu Quan-Sheng Su Hong-Ju Yu Ji-Hong Yang |
| author_facet | Li-Jun Xue Xiao-Bei Mao Xiao-Bei Liu Quan-Sheng Su Hong-Ju Yu Ji-Hong Yang |
| author_sort | Li-Jun Xue |
| collection | DOAJ |
| description | Peripheral T-cell lymphoma (PTCL) is rare and difficult to treat for its high relapse rate. The authors report a case of PTCL of the skin, regarding which clinical and pathological features, treatment, and prognosis were discussed. A 66-year-old woman was admitted with complaints of enlarging erythematous noduloplaques on the right anterior tibial skin for one year and similar lesions on the left for 6 months. Surgical resection of right leg lesion and biopsy of enlarged inguinal lymph nodes histologically indicated a PTCL of the nasal type. The patient was treated by CHOP plus bortezomib, reached complete remission just after two courses of chemotherapy and then received another two as consolidation. The patient remained in remission for 11 months until local relapse. As for cutaneous lesions, detailed lymph node examination and prompt tissue biopsy are judicious choices prior to any medical management. The chemotherapy consisting of bortezomib and CHOP is safe and efficient in PTCL of the skin. |
| format | Article |
| id | doaj-art-a648e03583c94adcaba435ed64a90813 |
| institution | OA Journals |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-a648e03583c94adcaba435ed64a908132025-08-20T02:20:48ZengWileyCase Reports in Medicine1687-96271687-96352010-01-01201010.1155/2010/403237403237Rapid Remission in Peripheral T-Cell Lymphoma of the Nasal Type by the Bortezomib plus CHOP TherapyLi-Jun Xue0Xiao-Bei Mao1Xiao-Bei Liu2Quan-Sheng Su3Hong-Ju Yu4Ji-Hong Yang5Department of Oncology and Hematology, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhong-shan Road, Nanjing, Jiangsu Province 210002, ChinaDepartment of Oncology and Hematology, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhong-shan Road, Nanjing, Jiangsu Province 210002, ChinaDepartment of Oncology and Hematology, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhong-shan Road, Nanjing, Jiangsu Province 210002, ChinaDepartment of Oncology and Hematology, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhong-shan Road, Nanjing, Jiangsu Province 210002, ChinaDepartment of Oncology and Hematology, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhong-shan Road, Nanjing, Jiangsu Province 210002, ChinaDepartment of Oncology and Hematology, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhong-shan Road, Nanjing, Jiangsu Province 210002, ChinaPeripheral T-cell lymphoma (PTCL) is rare and difficult to treat for its high relapse rate. The authors report a case of PTCL of the skin, regarding which clinical and pathological features, treatment, and prognosis were discussed. A 66-year-old woman was admitted with complaints of enlarging erythematous noduloplaques on the right anterior tibial skin for one year and similar lesions on the left for 6 months. Surgical resection of right leg lesion and biopsy of enlarged inguinal lymph nodes histologically indicated a PTCL of the nasal type. The patient was treated by CHOP plus bortezomib, reached complete remission just after two courses of chemotherapy and then received another two as consolidation. The patient remained in remission for 11 months until local relapse. As for cutaneous lesions, detailed lymph node examination and prompt tissue biopsy are judicious choices prior to any medical management. The chemotherapy consisting of bortezomib and CHOP is safe and efficient in PTCL of the skin.http://dx.doi.org/10.1155/2010/403237 |
| spellingShingle | Li-Jun Xue Xiao-Bei Mao Xiao-Bei Liu Quan-Sheng Su Hong-Ju Yu Ji-Hong Yang Rapid Remission in Peripheral T-Cell Lymphoma of the Nasal Type by the Bortezomib plus CHOP Therapy Case Reports in Medicine |
| title | Rapid Remission in Peripheral T-Cell Lymphoma of the Nasal Type by the Bortezomib plus CHOP Therapy |
| title_full | Rapid Remission in Peripheral T-Cell Lymphoma of the Nasal Type by the Bortezomib plus CHOP Therapy |
| title_fullStr | Rapid Remission in Peripheral T-Cell Lymphoma of the Nasal Type by the Bortezomib plus CHOP Therapy |
| title_full_unstemmed | Rapid Remission in Peripheral T-Cell Lymphoma of the Nasal Type by the Bortezomib plus CHOP Therapy |
| title_short | Rapid Remission in Peripheral T-Cell Lymphoma of the Nasal Type by the Bortezomib plus CHOP Therapy |
| title_sort | rapid remission in peripheral t cell lymphoma of the nasal type by the bortezomib plus chop therapy |
| url | http://dx.doi.org/10.1155/2010/403237 |
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