Influenza A Virus Entry: Implications in Virulence and Future Therapeutics
Influenza A viruses have broad host tropism, being able to infect a range of hosts from wild fowl to swine to humans. This broad tropism makes highly pathogenic influenza A strains, such as H5N1, potentially dangerous to humans if they gain the ability to jump from an animal reservoir to humans. How...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2013/121924 |
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| _version_ | 1832555154255118336 |
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| author | Emily Rumschlag-Booms Lijun Rong |
| author_facet | Emily Rumschlag-Booms Lijun Rong |
| author_sort | Emily Rumschlag-Booms |
| collection | DOAJ |
| description | Influenza A viruses have broad host tropism, being able to infect a range of hosts from wild fowl to swine to humans. This broad tropism makes highly pathogenic influenza A strains, such as H5N1, potentially dangerous to humans if they gain the ability to jump from an animal reservoir to humans. How influenza A viruses are able to jump the species barrier is incompletely understood due to the complex genetic nature of the viral surface glycoprotein, hemagglutinin, which mediates entry, combined with the virus's ability to use various receptor linkages. Current therapeutics against influenza A include those that target the uncoating process after entry as well as those that prevent viral budding. While there are therapeutics in development that target entry, currently there are none clinically available. We review here the genetics of influenza A viruses that contribute to entry tropism, how these genetic alterations may contribute to receptor usage and species tropism, as well as how novel therapeutics can be developed that target the major surface glycoprotein, hemagglutinin. |
| format | Article |
| id | doaj-art-a647585e4eb04028ad8966f969a43720 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-a647585e4eb04028ad8966f969a437202025-02-03T05:49:27ZengWileyAdvances in Virology1687-86391687-86472013-01-01201310.1155/2013/121924121924Influenza A Virus Entry: Implications in Virulence and Future TherapeuticsEmily Rumschlag-Booms0Lijun Rong1Department of Biology, Northeastern Illinois University, Chicago, Chicago, IL 60625, USADepartment of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, IL 60612, USAInfluenza A viruses have broad host tropism, being able to infect a range of hosts from wild fowl to swine to humans. This broad tropism makes highly pathogenic influenza A strains, such as H5N1, potentially dangerous to humans if they gain the ability to jump from an animal reservoir to humans. How influenza A viruses are able to jump the species barrier is incompletely understood due to the complex genetic nature of the viral surface glycoprotein, hemagglutinin, which mediates entry, combined with the virus's ability to use various receptor linkages. Current therapeutics against influenza A include those that target the uncoating process after entry as well as those that prevent viral budding. While there are therapeutics in development that target entry, currently there are none clinically available. We review here the genetics of influenza A viruses that contribute to entry tropism, how these genetic alterations may contribute to receptor usage and species tropism, as well as how novel therapeutics can be developed that target the major surface glycoprotein, hemagglutinin.http://dx.doi.org/10.1155/2013/121924 |
| spellingShingle | Emily Rumschlag-Booms Lijun Rong Influenza A Virus Entry: Implications in Virulence and Future Therapeutics Advances in Virology |
| title | Influenza A Virus Entry: Implications in Virulence and Future Therapeutics |
| title_full | Influenza A Virus Entry: Implications in Virulence and Future Therapeutics |
| title_fullStr | Influenza A Virus Entry: Implications in Virulence and Future Therapeutics |
| title_full_unstemmed | Influenza A Virus Entry: Implications in Virulence and Future Therapeutics |
| title_short | Influenza A Virus Entry: Implications in Virulence and Future Therapeutics |
| title_sort | influenza a virus entry implications in virulence and future therapeutics |
| url | http://dx.doi.org/10.1155/2013/121924 |
| work_keys_str_mv | AT emilyrumschlagbooms influenzaavirusentryimplicationsinvirulenceandfuturetherapeutics AT lijunrong influenzaavirusentryimplicationsinvirulenceandfuturetherapeutics |