Acupuncture for chronic insomnia disorder: a systematic review with meta-analysis and trial sequential analysis
ObjectiveTo investigate the effect of placebo response to acupuncture on subjective and objective sleep indices in patients with chronic insomnia disorder and to understand the effectiveness of acupuncture in the treatment of chronic insomnia disorder (CID).MethodsA comprehensive search was conducte...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1541276/full |
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| author | Yi Yu Yi Yu Xinju Li Zheng Zhu Zheng Zhu Yingdong Wang Yingdong Wang Qiang Xi Jiwen Qiu Yidan Xu Ruonan Liang Yi Guo Mingxing Zhang |
| author_facet | Yi Yu Yi Yu Xinju Li Zheng Zhu Zheng Zhu Yingdong Wang Yingdong Wang Qiang Xi Jiwen Qiu Yidan Xu Ruonan Liang Yi Guo Mingxing Zhang |
| author_sort | Yi Yu |
| collection | DOAJ |
| description | ObjectiveTo investigate the effect of placebo response to acupuncture on subjective and objective sleep indices in patients with chronic insomnia disorder and to understand the effectiveness of acupuncture in the treatment of chronic insomnia disorder (CID).MethodsA comprehensive search was conducted from the inception of the databases to March 17, 2025, encompassing eight databases. A randomized controlled pilot study of collecting acupuncture versus sham acupuncture for the treatment of CID. Systematic collection of acupuncture therapies for CID was performed based on randomized controlled trials (RCTs). Independent researchers critically reviewed the literature, recorded relevant data, and assessed the quality of research. Data were analyzed using RevMan 5.3, Stata 17.0, and TSA 0.9.5.10.ResultsThe study included a total of 757 patients across 10 trials. Acupuncture demonstrated significant improvement in PSQI scores [MD = −2.60, 95% CI = (−3.24, −1.97), p < 0.00001] and ISI scores (MD = −2.04, 95% CI = [−3.18, −0.90], p = 0.0005) compared to sham acupuncture. Sequential analyses of the trials showed stable results. Subgroup analyses showed that manual acupuncture and electroacupuncture were superior to sham acupuncture in improving PSQI scores [MD = −3.85, 95% CI = (−4.94, −2.76), p < 0.00001; MD = −1.67, 95% CI = (−2.25, −1.08), p < 0.00001]. Manual acupuncture and electroacupuncture were superior to sham acupuncture in improving ISI scores [MD = −2.60, 95% CI = (−4.72, −0.48), p = 0.02; MD = −1.93, 95% CI = (−3.16, −0.71), p = 0.002]. In terms of objective sleep indices, there was no statistically significant difference in total sleep time between acupuncture and sham acupuncture [MD = 11.92, 95% CI = (−20.25, 44.09), p = 0.47]. Acupuncture was superior to sham acupuncture in terms of sleep efficiency and wake after sleep onset [MD = 3.62, 95% CI = (0.92, 6.32), p = 0.009; MD = −18.53, 95% CI = (−29.22, −7.85), p = 0.0007]. However, the sequential analysis indicated limitations due to small sample size which hindered drawing definitive conclusions.ConclusionCompared with sham acupuncture, acupuncture is effective in improving subjective sleep quality in patients with CID. However, whether acupuncture improves patients’ objective sleep indices compared to sham acupuncture is uncertain and more high-quality clinical trial evidence is needed to validate this.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, Identifier CRD42024541760. |
| format | Article |
| id | doaj-art-a64217491c1540ddabcfb23e50c8ca9d |
| institution | DOAJ |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-a64217491c1540ddabcfb23e50c8ca9d2025-08-20T03:19:17ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-04-011610.3389/fneur.2025.15412761541276Acupuncture for chronic insomnia disorder: a systematic review with meta-analysis and trial sequential analysisYi Yu0Yi Yu1Xinju Li2Zheng Zhu3Zheng Zhu4Yingdong Wang5Yingdong Wang6Qiang Xi7Jiwen Qiu8Yidan Xu9Ruonan Liang10Yi Guo11Mingxing Zhang12School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Intergrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Intergrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Intergrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaObjectiveTo investigate the effect of placebo response to acupuncture on subjective and objective sleep indices in patients with chronic insomnia disorder and to understand the effectiveness of acupuncture in the treatment of chronic insomnia disorder (CID).MethodsA comprehensive search was conducted from the inception of the databases to March 17, 2025, encompassing eight databases. A randomized controlled pilot study of collecting acupuncture versus sham acupuncture for the treatment of CID. Systematic collection of acupuncture therapies for CID was performed based on randomized controlled trials (RCTs). Independent researchers critically reviewed the literature, recorded relevant data, and assessed the quality of research. Data were analyzed using RevMan 5.3, Stata 17.0, and TSA 0.9.5.10.ResultsThe study included a total of 757 patients across 10 trials. Acupuncture demonstrated significant improvement in PSQI scores [MD = −2.60, 95% CI = (−3.24, −1.97), p < 0.00001] and ISI scores (MD = −2.04, 95% CI = [−3.18, −0.90], p = 0.0005) compared to sham acupuncture. Sequential analyses of the trials showed stable results. Subgroup analyses showed that manual acupuncture and electroacupuncture were superior to sham acupuncture in improving PSQI scores [MD = −3.85, 95% CI = (−4.94, −2.76), p < 0.00001; MD = −1.67, 95% CI = (−2.25, −1.08), p < 0.00001]. Manual acupuncture and electroacupuncture were superior to sham acupuncture in improving ISI scores [MD = −2.60, 95% CI = (−4.72, −0.48), p = 0.02; MD = −1.93, 95% CI = (−3.16, −0.71), p = 0.002]. In terms of objective sleep indices, there was no statistically significant difference in total sleep time between acupuncture and sham acupuncture [MD = 11.92, 95% CI = (−20.25, 44.09), p = 0.47]. Acupuncture was superior to sham acupuncture in terms of sleep efficiency and wake after sleep onset [MD = 3.62, 95% CI = (0.92, 6.32), p = 0.009; MD = −18.53, 95% CI = (−29.22, −7.85), p = 0.0007]. However, the sequential analysis indicated limitations due to small sample size which hindered drawing definitive conclusions.ConclusionCompared with sham acupuncture, acupuncture is effective in improving subjective sleep quality in patients with CID. However, whether acupuncture improves patients’ objective sleep indices compared to sham acupuncture is uncertain and more high-quality clinical trial evidence is needed to validate this.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, Identifier CRD42024541760.https://www.frontiersin.org/articles/10.3389/fneur.2025.1541276/fullacupuncturechronic insomnia disordersystematic reviewmeta-analysistrial sequential analysis |
| spellingShingle | Yi Yu Yi Yu Xinju Li Zheng Zhu Zheng Zhu Yingdong Wang Yingdong Wang Qiang Xi Jiwen Qiu Yidan Xu Ruonan Liang Yi Guo Mingxing Zhang Acupuncture for chronic insomnia disorder: a systematic review with meta-analysis and trial sequential analysis Frontiers in Neurology acupuncture chronic insomnia disorder systematic review meta-analysis trial sequential analysis |
| title | Acupuncture for chronic insomnia disorder: a systematic review with meta-analysis and trial sequential analysis |
| title_full | Acupuncture for chronic insomnia disorder: a systematic review with meta-analysis and trial sequential analysis |
| title_fullStr | Acupuncture for chronic insomnia disorder: a systematic review with meta-analysis and trial sequential analysis |
| title_full_unstemmed | Acupuncture for chronic insomnia disorder: a systematic review with meta-analysis and trial sequential analysis |
| title_short | Acupuncture for chronic insomnia disorder: a systematic review with meta-analysis and trial sequential analysis |
| title_sort | acupuncture for chronic insomnia disorder a systematic review with meta analysis and trial sequential analysis |
| topic | acupuncture chronic insomnia disorder systematic review meta-analysis trial sequential analysis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1541276/full |
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