Related factors and prognostic impact of cardiac valve calcification in maintenance hemodialysis patients
ObjectiveTo explore risk factors for cardiac valve calcification (CVC) in maintenance hemodialysis (MHD) patients and evaluate its impact on cardiovascular events and mortality. MethodsRetrospective selection of 223 patients with MHD admitted to the Department of Nephrology of Jinshan Hospital, Fuda...
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Shanghai Chinese Clinical Medicine Press Co., Ltd.
2025-08-01
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| Series: | Zhongguo Linchuang Yixue |
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| Online Access: | https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20241559 |
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| author | Chengjun WANG Xiaorong BAO Zixuan QIAO Miao MIAO Wei YE Lizhen WANG Zhengjia HE Jiao WANG |
| author_facet | Chengjun WANG Xiaorong BAO Zixuan QIAO Miao MIAO Wei YE Lizhen WANG Zhengjia HE Jiao WANG |
| author_sort | Chengjun WANG |
| collection | DOAJ |
| description | ObjectiveTo explore risk factors for cardiac valve calcification (CVC) in maintenance hemodialysis (MHD) patients and evaluate its impact on cardiovascular events and mortality. MethodsRetrospective selection of 223 patients with MHD admitted to the Department of Nephrology of Jinshan Hospital, Fudan University from June 30, 2019 to June 30, 2024, and enrollment completed within one week of June 30, 2019. Patients were divided into CVC and non-CVC groups. Baseline data and 5-year follow-up data were collected. The binary logistic regression analysis was performed to explore the risk factors for CVC. Kaplan-Meier survival curve was used to analyze the survival rate of patients. Cox proportional hazard regression model was applied to evaluate the impact of CVC on the survival rates of MHD patients. ResultsTotally, 223 MHD patients with an average age of (58.4±13.5) years and an average dialysis duration of (64.0±55.4) months were involved. Among them, 136(61.0%) were males, 117(52.5%) were complicated with CVC. Age, dialysis duration, diabetic kidney disease (DKD), the serum corrected total calcium and phosphate, intact parathyroid hormone (iPTH), high-sensitive C-reactive protein (hsCRP), and homocysteine (Hcy) were independent related factors for CVC (P＜0.05). Both all-cause mortality (46.6% vs 28.7%) and cardiovascular mortality (33.3% vs 16.0%) were significantly higher in the CVC group than those in the non-CVC group (P＜0.01). ConclusionsAge, dialysis duration, the primary disease, calcium and phosphate, and inflammation- and nutrition-related serum indicators are associated with CVC in MHD patients. CVC significantly increases mortality risk of MHD patients. |
| format | Article |
| id | doaj-art-a63eff839a954a2ea93d9a997152669a |
| institution | Kabale University |
| issn | 1008-6358 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Shanghai Chinese Clinical Medicine Press Co., Ltd. |
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| series | Zhongguo Linchuang Yixue |
| spelling | doaj-art-a63eff839a954a2ea93d9a997152669a2025-08-26T01:29:39ZengShanghai Chinese Clinical Medicine Press Co., Ltd.Zhongguo Linchuang Yixue1008-63582025-08-0132456857710.12025/j.issn.1008-6358.2025.2024155920241559Related factors and prognostic impact of cardiac valve calcification in maintenance hemodialysis patientsChengjun WANG0Xiaorong BAO1Zixuan QIAO2Miao MIAO3Wei YE4Lizhen WANG5Zhengjia HE6Jiao WANG7Department of Nephrology, Jinshan Hospital, Fudan University, Shanghai 201508, ChinaDepartment of Nephrology, Jinshan Hospital, Fudan University, Shanghai 201508, ChinaDepartment of Nephrology, Jinshan Hospital, Fudan University, Shanghai 201508, ChinaDepartment of Nephrology, Jinshan Hospital, Fudan University, Shanghai 201508, ChinaDepartment of Nephrology, Jinshan Hospital, Fudan University, Shanghai 201508, ChinaDepartment of Nephrology, Jinshan Hospital, Fudan University, Shanghai 201508, ChinaDepartment of Nephrology, Jinshan Hospital, Fudan University, Shanghai 201508, ChinaDepartment of Nephrology, Jinshan Hospital, Fudan University, Shanghai 201508, ChinaObjectiveTo explore risk factors for cardiac valve calcification (CVC) in maintenance hemodialysis (MHD) patients and evaluate its impact on cardiovascular events and mortality. MethodsRetrospective selection of 223 patients with MHD admitted to the Department of Nephrology of Jinshan Hospital, Fudan University from June 30, 2019 to June 30, 2024, and enrollment completed within one week of June 30, 2019. Patients were divided into CVC and non-CVC groups. Baseline data and 5-year follow-up data were collected. The binary logistic regression analysis was performed to explore the risk factors for CVC. Kaplan-Meier survival curve was used to analyze the survival rate of patients. Cox proportional hazard regression model was applied to evaluate the impact of CVC on the survival rates of MHD patients. ResultsTotally, 223 MHD patients with an average age of (58.4±13.5) years and an average dialysis duration of (64.0±55.4) months were involved. Among them, 136(61.0%) were males, 117(52.5%) were complicated with CVC. Age, dialysis duration, diabetic kidney disease (DKD), the serum corrected total calcium and phosphate, intact parathyroid hormone (iPTH), high-sensitive C-reactive protein (hsCRP), and homocysteine (Hcy) were independent related factors for CVC (P＜0.05). Both all-cause mortality (46.6% vs 28.7%) and cardiovascular mortality (33.3% vs 16.0%) were significantly higher in the CVC group than those in the non-CVC group (P＜0.01). ConclusionsAge, dialysis duration, the primary disease, calcium and phosphate, and inflammation- and nutrition-related serum indicators are associated with CVC in MHD patients. CVC significantly increases mortality risk of MHD patients.https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20241559maintenance hemodialysiscardiac valve calcificationrisk factorcardiovascular eventmortality |
| spellingShingle | Chengjun WANG Xiaorong BAO Zixuan QIAO Miao MIAO Wei YE Lizhen WANG Zhengjia HE Jiao WANG Related factors and prognostic impact of cardiac valve calcification in maintenance hemodialysis patients Zhongguo Linchuang Yixue maintenance hemodialysis cardiac valve calcification risk factor cardiovascular event mortality |
| title | Related factors and prognostic impact of cardiac valve calcification in maintenance hemodialysis patients |
| title_full | Related factors and prognostic impact of cardiac valve calcification in maintenance hemodialysis patients |
| title_fullStr | Related factors and prognostic impact of cardiac valve calcification in maintenance hemodialysis patients |
| title_full_unstemmed | Related factors and prognostic impact of cardiac valve calcification in maintenance hemodialysis patients |
| title_short | Related factors and prognostic impact of cardiac valve calcification in maintenance hemodialysis patients |
| title_sort | related factors and prognostic impact of cardiac valve calcification in maintenance hemodialysis patients |
| topic | maintenance hemodialysis cardiac valve calcification risk factor cardiovascular event mortality |
| url | https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20241559 |
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