Adult Mesenchymal Stem Cells: When, Where, and How
Adult mesenchymal stem cells (MSCs) have profound medicinal effects at body sites of tissue injury, disease, or inflammation as either endogenously or exogenously supplied. The medicinal effects are either immunomodulatory or trophic or both. When to deliver these mediators of regeneration, where,...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/628767 |
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| _version_ | 1850169217810169856 |
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| author | Arnold I. Caplan |
| author_facet | Arnold I. Caplan |
| author_sort | Arnold I. Caplan |
| collection | DOAJ |
| description | Adult mesenchymal stem cells (MSCs) have profound medicinal effects at body sites of tissue injury, disease, or inflammation as either endogenously or exogenously supplied. The medicinal effects are either immunomodulatory or trophic or both. When to deliver these mediators of regeneration, where, and by what delivery apparatus or mechanism will directly determine their medical efficacy. The MSCs help manage the innate regenerative capacity of almost every body tissue and the MSCs have only recently been fully appreciated. Perhaps the most skilled physician-manager of the body’s innate regenerative capacity is in orthopedics where the vigorous regeneration and repair capacity of bone through local MSCs-titers is expertly managed by the orthopaedic physician. The challenge is to extend MSCs expertise to address other tissue dysfunctions and diseases. The medicine of tomorrow will encompass optimizing the tissues’ intrinsic regenerative potential through management of local MSCs. |
| format | Article |
| id | doaj-art-a63b93f2dd014c028ea963e860e82b47 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-a63b93f2dd014c028ea963e860e82b472025-08-20T02:20:47ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/628767628767Adult Mesenchymal Stem Cells: When, Where, and HowArnold I. Caplan0Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USAAdult mesenchymal stem cells (MSCs) have profound medicinal effects at body sites of tissue injury, disease, or inflammation as either endogenously or exogenously supplied. The medicinal effects are either immunomodulatory or trophic or both. When to deliver these mediators of regeneration, where, and by what delivery apparatus or mechanism will directly determine their medical efficacy. The MSCs help manage the innate regenerative capacity of almost every body tissue and the MSCs have only recently been fully appreciated. Perhaps the most skilled physician-manager of the body’s innate regenerative capacity is in orthopedics where the vigorous regeneration and repair capacity of bone through local MSCs-titers is expertly managed by the orthopaedic physician. The challenge is to extend MSCs expertise to address other tissue dysfunctions and diseases. The medicine of tomorrow will encompass optimizing the tissues’ intrinsic regenerative potential through management of local MSCs.http://dx.doi.org/10.1155/2015/628767 |
| spellingShingle | Arnold I. Caplan Adult Mesenchymal Stem Cells: When, Where, and How Stem Cells International |
| title | Adult Mesenchymal Stem Cells: When, Where, and How |
| title_full | Adult Mesenchymal Stem Cells: When, Where, and How |
| title_fullStr | Adult Mesenchymal Stem Cells: When, Where, and How |
| title_full_unstemmed | Adult Mesenchymal Stem Cells: When, Where, and How |
| title_short | Adult Mesenchymal Stem Cells: When, Where, and How |
| title_sort | adult mesenchymal stem cells when where and how |
| url | http://dx.doi.org/10.1155/2015/628767 |
| work_keys_str_mv | AT arnoldicaplan adultmesenchymalstemcellswhenwhereandhow |