Multi-shot gradient-echo planar imaging sequence in non-contrast coronary magnetic resonance angiography
ObjectiveTo explore the feasibility of multi-shot gradient-echo planar imaging (MSG-EPI) sequence in non-enhanced coronary artery magnetic resonance angiography (CMRA).MethodsPatients undergoing CMRA in the Geriatric Hospital of Nanjing Medical University from November 2023 to May 2024 were included...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1496853/full |
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| author | Jiajia Zhu Wenjing Li Guangming Lu Dongsheng Jin Qiuju Hu Yong Yuan Song Luo Yane Zhao |
| author_facet | Jiajia Zhu Wenjing Li Guangming Lu Dongsheng Jin Qiuju Hu Yong Yuan Song Luo Yane Zhao |
| author_sort | Jiajia Zhu |
| collection | DOAJ |
| description | ObjectiveTo explore the feasibility of multi-shot gradient-echo planar imaging (MSG-EPI) sequence in non-enhanced coronary artery magnetic resonance angiography (CMRA).MethodsPatients undergoing CMRA in the Geriatric Hospital of Nanjing Medical University from November 2023 to May 2024 were included. We compared MSG-EPI and three-dimensional balanced turbo field echo (3D BTFE) sequence in acquisition time, subjective image score, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). With CTA as the reference standard, the linear weighted kappa and compared chi-square Mcnemar test were used to evaluate the diagnostic efficacy of both sequences for coronary artery diseases (CADs). The scale for the kappa coefficients was interpreted as follows: <0.2 = poor, 0.2–0.4 = fair, 0.4–0.6 = moderate, 0.6–0.8 = substantial, and >0.8 = excellent.ResultSeventy-two patients (33 males; mean age 54.5 ± 14.7 years old, range from 18 to 79 years old) were enrolled. MSG-EPI had a significantly shorter acquisition time than 3D BTFE (17.21 ± 1.08 s vs. 558.10 ± 102.90 s, P < 0.001). No significant differences in subjective scores were found between sequences for the proximal and middle segment of RCA, LM, the proximal segment of LAD and LCX (P = 0.168, 0.097, 0.126, 0.065, 0.062, respectively). SNR evaluations revealed no significant differences in the proximal and middle segment of RCA and LM segment (P = 0.119, 0.105, 0.237, respectively). However, in coronary artery segment analysis, the CNR was significantly higher in 3D BTFE compared to MSG-EPI (P all <0.05). The kappa values for MSG-EPI and 3D BTFE in assessing stenosis were 0.785 and 0.814, respectively. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of MSG-EPI were 86.7%, 83.3%, 76.5%, 90.9%, and 84.6%, respectively. The area under the curve (AUC) of MSF-EPI and 3D BTFE for CADs diagnosis was 0.850 (0.699–0.944) and 0.879 (0.735–0.961), respectively (P = 0.543).ConclusionMSG-EPI sequence could significantly shorten the acquisition time and provide sufficient image quality for CADs evaluation in non-enhanced CMRA. |
| format | Article |
| id | doaj-art-a63845ede7a04d05aa5aed40ac30d355 |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-06-01 |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-a63845ede7a04d05aa5aed40ac30d3552025-08-20T02:01:47ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-06-011210.3389/fcvm.2025.14968531496853Multi-shot gradient-echo planar imaging sequence in non-contrast coronary magnetic resonance angiographyJiajia Zhu0Wenjing Li1Guangming Lu2Dongsheng Jin3Qiuju Hu4Yong Yuan5Song Luo6Yane Zhao7Department of Radiology, Geriatric Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Geriatric Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Jinling Hospital Affiliated to Nanjing University, Nanjing, ChinaDepartment of Radiology, Geriatric Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Geriatric Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Geriatric Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Geriatric Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Geriatric Hospital of Nanjing Medical University, Nanjing, ChinaObjectiveTo explore the feasibility of multi-shot gradient-echo planar imaging (MSG-EPI) sequence in non-enhanced coronary artery magnetic resonance angiography (CMRA).MethodsPatients undergoing CMRA in the Geriatric Hospital of Nanjing Medical University from November 2023 to May 2024 were included. We compared MSG-EPI and three-dimensional balanced turbo field echo (3D BTFE) sequence in acquisition time, subjective image score, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). With CTA as the reference standard, the linear weighted kappa and compared chi-square Mcnemar test were used to evaluate the diagnostic efficacy of both sequences for coronary artery diseases (CADs). The scale for the kappa coefficients was interpreted as follows: <0.2 = poor, 0.2–0.4 = fair, 0.4–0.6 = moderate, 0.6–0.8 = substantial, and >0.8 = excellent.ResultSeventy-two patients (33 males; mean age 54.5 ± 14.7 years old, range from 18 to 79 years old) were enrolled. MSG-EPI had a significantly shorter acquisition time than 3D BTFE (17.21 ± 1.08 s vs. 558.10 ± 102.90 s, P < 0.001). No significant differences in subjective scores were found between sequences for the proximal and middle segment of RCA, LM, the proximal segment of LAD and LCX (P = 0.168, 0.097, 0.126, 0.065, 0.062, respectively). SNR evaluations revealed no significant differences in the proximal and middle segment of RCA and LM segment (P = 0.119, 0.105, 0.237, respectively). However, in coronary artery segment analysis, the CNR was significantly higher in 3D BTFE compared to MSG-EPI (P all <0.05). The kappa values for MSG-EPI and 3D BTFE in assessing stenosis were 0.785 and 0.814, respectively. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of MSG-EPI were 86.7%, 83.3%, 76.5%, 90.9%, and 84.6%, respectively. The area under the curve (AUC) of MSF-EPI and 3D BTFE for CADs diagnosis was 0.850 (0.699–0.944) and 0.879 (0.735–0.961), respectively (P = 0.543).ConclusionMSG-EPI sequence could significantly shorten the acquisition time and provide sufficient image quality for CADs evaluation in non-enhanced CMRA.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1496853/fullmagnetic resonance imagingecho-plane imagingimage qualitydiagnostic efficiencycoronary artery |
| spellingShingle | Jiajia Zhu Wenjing Li Guangming Lu Dongsheng Jin Qiuju Hu Yong Yuan Song Luo Yane Zhao Multi-shot gradient-echo planar imaging sequence in non-contrast coronary magnetic resonance angiography Frontiers in Cardiovascular Medicine magnetic resonance imaging echo-plane imaging image quality diagnostic efficiency coronary artery |
| title | Multi-shot gradient-echo planar imaging sequence in non-contrast coronary magnetic resonance angiography |
| title_full | Multi-shot gradient-echo planar imaging sequence in non-contrast coronary magnetic resonance angiography |
| title_fullStr | Multi-shot gradient-echo planar imaging sequence in non-contrast coronary magnetic resonance angiography |
| title_full_unstemmed | Multi-shot gradient-echo planar imaging sequence in non-contrast coronary magnetic resonance angiography |
| title_short | Multi-shot gradient-echo planar imaging sequence in non-contrast coronary magnetic resonance angiography |
| title_sort | multi shot gradient echo planar imaging sequence in non contrast coronary magnetic resonance angiography |
| topic | magnetic resonance imaging echo-plane imaging image quality diagnostic efficiency coronary artery |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1496853/full |
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