Primary results from the Japanese Heart Failure and Sudden Cardiac Death Prevention Trial (HINODE)
Abstract Aims The HINODE study aimed to analyse rates of mortality, appropriately treated ventricular arrhythmias (VA), and heart failure in Japanese patients and compared with those in Western patients. Methods and results After treatment decisions following contemporary practice in Japan, patients...
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Wiley
2022-06-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.13901 |
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| author | Kazutaka Aonuma Kenji Ando Kengo Kusano Toru Asai Koichi Inoue Yukihiro Inamura Takanori Ikeda Takeshi Mitsuhashi Toyoaki Murohara Nobuhiro Nishii Akihiko Nogami Wataru Shimizu Caroline Beaudoint Torri Simon Torsten Kayser Hussin Azlan Ngarmukos Tachapong Joseph Yat‐Sun Chan Valentina Kutyifa Yasushi Sakata For the HINODE Investigators |
| author_facet | Kazutaka Aonuma Kenji Ando Kengo Kusano Toru Asai Koichi Inoue Yukihiro Inamura Takanori Ikeda Takeshi Mitsuhashi Toyoaki Murohara Nobuhiro Nishii Akihiko Nogami Wataru Shimizu Caroline Beaudoint Torri Simon Torsten Kayser Hussin Azlan Ngarmukos Tachapong Joseph Yat‐Sun Chan Valentina Kutyifa Yasushi Sakata For the HINODE Investigators |
| author_sort | Kazutaka Aonuma |
| collection | DOAJ |
| description | Abstract Aims The HINODE study aimed to analyse rates of mortality, appropriately treated ventricular arrhythmias (VA), and heart failure in Japanese patients and compared with those in Western patients. Methods and results After treatment decisions following contemporary practice in Japan, patients were prospectively enrolled into four cohorts: (i) internal cardioverter‐defibrillator (ICD), (ii) cardiac resynchronization therapy (CRT) defibrillator (CRT‐D), (iii) standard medical therapy (‘non‐device’: ND), or (iv) pacing (indicated for CRT; received pacemaker or CRT pacing). Cohorts 1–3 required a left ventricular ejection fraction ≤35%, a history of heart failure, and a need for primary prevention of sudden cardiac death based on two to five previously identified risk factors. Endpoint outcomes were adjudicated by the independent committees. ICD and CRT‐D cohorts, considered as high‐voltage (HV) cohorts, were pooled for Kaplan–Meier analysis and propensity‐matched to Multicenter Automatic Defibrillator Implantation Trial‐Reduce Inappropriate Therapy (MADIT‐RIT) arm B and C patients. The study enrolled 354 patients followed for 19.6 ± 6.5 months, with a minimum of 12 months. Propensity‐matched HV cohorts showed comparable VA (P = 0.61) and mortality rates (P = 0.29) for HINODE and MADIT‐RIT. The ND cohort presented a high crossover rate to ICD therapy (6.1%, n = 7/115), and the CRT‐D cohort showed elevated mortality rates. The pacing cohort revealed that patients implanted with pacemakers had higher mortality (26.0%) than those with CRT‐Pacing (8.4%, P = 0.05). Conclusions The mortality and VA event rates of landmark trials are applicable to patients with primary prevention in Japan. Patients who did not receive guideline‐indicated CRT devices had poor outcomes. |
| format | Article |
| id | doaj-art-a636dec6061c4ae685c3062cb71cf93b |
| institution | Kabale University |
| issn | 2055-5822 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj-art-a636dec6061c4ae685c3062cb71cf93b2025-02-05T05:22:10ZengWileyESC Heart Failure2055-58222022-06-01931584159610.1002/ehf2.13901Primary results from the Japanese Heart Failure and Sudden Cardiac Death Prevention Trial (HINODE)Kazutaka Aonuma0Kenji Ando1Kengo Kusano2Toru Asai3Koichi Inoue4Yukihiro Inamura5Takanori Ikeda6Takeshi Mitsuhashi7Toyoaki Murohara8Nobuhiro Nishii9Akihiko Nogami10Wataru Shimizu11Caroline Beaudoint12Torri Simon13Torsten Kayser14Hussin Azlan15Ngarmukos Tachapong16Joseph Yat‐Sun Chan17Valentina Kutyifa18Yasushi Sakata19For the HINODE InvestigatorsUniversity of Tsukuba 1‐1‐1 Tennodai, Tsukuba Ibaraki 305‐8577 JapanKokura Memorial Hospital Fukuoka JapanNational Cerebral and Cardiovascular Center Osaka JapanIchinomiya Municipal Hospital Aichi JapanCardiovascular Division National Hospital Organization Osaka National Hospital Osaka JapanJapanese Red Cross Saitama Hospital Saitama JapanToho University Tokyo JapanHoshi General Hospital Fukushima JapanNagoya University Aichi JapanOkayama University Okayama JapanUniversity of Tsukuba 1‐1‐1 Tennodai, Tsukuba Ibaraki 305‐8577 JapanNippon Medical School Tokyo JapanBoston Scientific Diegem BelgiumBoston Scientific St. Paul MN USABoston Scientific Diegem BelgiumInstitut Jantung Negara Kuala Lumpur MalaysiaDepartment of Medicine, Faculty of Medicine at Ramathibodi Hospital Mahidol University Bangkok ThailandDepartment of Medicine and Therapeutics, Prince of Wales Hospital Chinese University of Hong Kong Shatin Hong KongUniversity of Rochester Rochester NY USAOsaka University Osaka JapanAbstract Aims The HINODE study aimed to analyse rates of mortality, appropriately treated ventricular arrhythmias (VA), and heart failure in Japanese patients and compared with those in Western patients. Methods and results After treatment decisions following contemporary practice in Japan, patients were prospectively enrolled into four cohorts: (i) internal cardioverter‐defibrillator (ICD), (ii) cardiac resynchronization therapy (CRT) defibrillator (CRT‐D), (iii) standard medical therapy (‘non‐device’: ND), or (iv) pacing (indicated for CRT; received pacemaker or CRT pacing). Cohorts 1–3 required a left ventricular ejection fraction ≤35%, a history of heart failure, and a need for primary prevention of sudden cardiac death based on two to five previously identified risk factors. Endpoint outcomes were adjudicated by the independent committees. ICD and CRT‐D cohorts, considered as high‐voltage (HV) cohorts, were pooled for Kaplan–Meier analysis and propensity‐matched to Multicenter Automatic Defibrillator Implantation Trial‐Reduce Inappropriate Therapy (MADIT‐RIT) arm B and C patients. The study enrolled 354 patients followed for 19.6 ± 6.5 months, with a minimum of 12 months. Propensity‐matched HV cohorts showed comparable VA (P = 0.61) and mortality rates (P = 0.29) for HINODE and MADIT‐RIT. The ND cohort presented a high crossover rate to ICD therapy (6.1%, n = 7/115), and the CRT‐D cohort showed elevated mortality rates. The pacing cohort revealed that patients implanted with pacemakers had higher mortality (26.0%) than those with CRT‐Pacing (8.4%, P = 0.05). Conclusions The mortality and VA event rates of landmark trials are applicable to patients with primary prevention in Japan. Patients who did not receive guideline‐indicated CRT devices had poor outcomes.https://doi.org/10.1002/ehf2.13901Defibrillator therapyVentricular arrhythmiaSudden cardiac deathJapan, primary preventionElectrophysiologic studies |
| spellingShingle | Kazutaka Aonuma Kenji Ando Kengo Kusano Toru Asai Koichi Inoue Yukihiro Inamura Takanori Ikeda Takeshi Mitsuhashi Toyoaki Murohara Nobuhiro Nishii Akihiko Nogami Wataru Shimizu Caroline Beaudoint Torri Simon Torsten Kayser Hussin Azlan Ngarmukos Tachapong Joseph Yat‐Sun Chan Valentina Kutyifa Yasushi Sakata For the HINODE Investigators Primary results from the Japanese Heart Failure and Sudden Cardiac Death Prevention Trial (HINODE) ESC Heart Failure Defibrillator therapy Ventricular arrhythmia Sudden cardiac death Japan, primary prevention Electrophysiologic studies |
| title | Primary results from the Japanese Heart Failure and Sudden Cardiac Death Prevention Trial (HINODE) |
| title_full | Primary results from the Japanese Heart Failure and Sudden Cardiac Death Prevention Trial (HINODE) |
| title_fullStr | Primary results from the Japanese Heart Failure and Sudden Cardiac Death Prevention Trial (HINODE) |
| title_full_unstemmed | Primary results from the Japanese Heart Failure and Sudden Cardiac Death Prevention Trial (HINODE) |
| title_short | Primary results from the Japanese Heart Failure and Sudden Cardiac Death Prevention Trial (HINODE) |
| title_sort | primary results from the japanese heart failure and sudden cardiac death prevention trial hinode |
| topic | Defibrillator therapy Ventricular arrhythmia Sudden cardiac death Japan, primary prevention Electrophysiologic studies |
| url | https://doi.org/10.1002/ehf2.13901 |
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