Human TCR repertoire in cancer
Abstract Background T cells, the “superstar” of the immune system, play a crucial role in antitumor immunity. T‐cell receptors (TCR) are crucial molecules that enable T cells to identify antigens and start immunological responses. The body has evolved a unique method for rearrangement, resulting in...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-09-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.70164 |
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| _version_ | 1825206499686744064 |
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| author | Lin Chen Yuan Hu Bohao Zheng Limei Luo Zhenzhen Su |
| author_facet | Lin Chen Yuan Hu Bohao Zheng Limei Luo Zhenzhen Su |
| author_sort | Lin Chen |
| collection | DOAJ |
| description | Abstract Background T cells, the “superstar” of the immune system, play a crucial role in antitumor immunity. T‐cell receptors (TCR) are crucial molecules that enable T cells to identify antigens and start immunological responses. The body has evolved a unique method for rearrangement, resulting in a vast diversity of TCR repertoires. A healthy TCR repertoire is essential for the particular identification of antigens by T cells. Methods In this article, we systematically summarized the TCR creation mechanisms and analysis methodologies, particularly focusing on the application of next‐generation sequencing (NGS) technology. We explore the TCR repertoire in health and cancer, and discuss the implications of TCR repertoire analysis in understanding carcinogenesis, cancer progression, and treatment. Results The TCR repertoire analysis has enormous potential for monitoring the emergence and progression of malignancies, as well as assessing therapy response and prognosis. The application of NGS has dramatically accelerated our comprehension of TCR diversity and its role in cancer immunity. Conclusions To substantiate the significance of TCR repertoires as biomarkers, more thorough and exhaustive research should be conducted. The TCR repertoire analysis, enabled by advanced sequencing technologies, is poised to become a crucial tool in the future of cancer diagnosis, monitoring, and therapy evaluation. |
| format | Article |
| id | doaj-art-a633a63133824276afef1ae9e699d442 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-a633a63133824276afef1ae9e699d4422025-02-07T09:08:08ZengWileyCancer Medicine2045-76342024-09-011317n/an/a10.1002/cam4.70164Human TCR repertoire in cancerLin Chen0Yuan Hu1Bohao Zheng2Limei Luo3Zhenzhen Su4Department of Medical Genetics/Prenatal Diagnostic Center West China Second University Hospital, Sichuan University Chengdu ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu ChinaDepartment of Laboratory Medicine West China Hospital of Sichuan University Chengdu ChinaDepartment of Laboratory Medicine West China Hospital of Sichuan University Chengdu ChinaAbstract Background T cells, the “superstar” of the immune system, play a crucial role in antitumor immunity. T‐cell receptors (TCR) are crucial molecules that enable T cells to identify antigens and start immunological responses. The body has evolved a unique method for rearrangement, resulting in a vast diversity of TCR repertoires. A healthy TCR repertoire is essential for the particular identification of antigens by T cells. Methods In this article, we systematically summarized the TCR creation mechanisms and analysis methodologies, particularly focusing on the application of next‐generation sequencing (NGS) technology. We explore the TCR repertoire in health and cancer, and discuss the implications of TCR repertoire analysis in understanding carcinogenesis, cancer progression, and treatment. Results The TCR repertoire analysis has enormous potential for monitoring the emergence and progression of malignancies, as well as assessing therapy response and prognosis. The application of NGS has dramatically accelerated our comprehension of TCR diversity and its role in cancer immunity. Conclusions To substantiate the significance of TCR repertoires as biomarkers, more thorough and exhaustive research should be conducted. The TCR repertoire analysis, enabled by advanced sequencing technologies, is poised to become a crucial tool in the future of cancer diagnosis, monitoring, and therapy evaluation.https://doi.org/10.1002/cam4.70164cancerimmunotherapynext‐generation sequencingT‐cell receptor |
| spellingShingle | Lin Chen Yuan Hu Bohao Zheng Limei Luo Zhenzhen Su Human TCR repertoire in cancer Cancer Medicine cancer immunotherapy next‐generation sequencing T‐cell receptor |
| title | Human TCR repertoire in cancer |
| title_full | Human TCR repertoire in cancer |
| title_fullStr | Human TCR repertoire in cancer |
| title_full_unstemmed | Human TCR repertoire in cancer |
| title_short | Human TCR repertoire in cancer |
| title_sort | human tcr repertoire in cancer |
| topic | cancer immunotherapy next‐generation sequencing T‐cell receptor |
| url | https://doi.org/10.1002/cam4.70164 |
| work_keys_str_mv | AT linchen humantcrrepertoireincancer AT yuanhu humantcrrepertoireincancer AT bohaozheng humantcrrepertoireincancer AT limeiluo humantcrrepertoireincancer AT zhenzhensu humantcrrepertoireincancer |