Anti-dipeptidyl-peptidase-like protein-6 (DPPX) autoimmune encephalitis associated with severe multifocal dystonia

Anti-DPPX encephalitis is a rare form of autoimmune encephalitis characterized antibodies against a subunit of Kv4.2 potassium channels. Characteristic clinical features include cognitive dysfunction, parasomnias, psychosis, and seizures. Motor symptoms typically include myoclonus, tremor, and midli...

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Main Authors: Eric Roddy, Erik Gentry, Victoria Holiday, David Robertson, Peter Hedera
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Clinical Parkinsonism & Related Disorders
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2590112525000246
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author Eric Roddy
Erik Gentry
Victoria Holiday
David Robertson
Peter Hedera
author_facet Eric Roddy
Erik Gentry
Victoria Holiday
David Robertson
Peter Hedera
author_sort Eric Roddy
collection DOAJ
description Anti-DPPX encephalitis is a rare form of autoimmune encephalitis characterized antibodies against a subunit of Kv4.2 potassium channels. Characteristic clinical features include cognitive dysfunction, parasomnias, psychosis, and seizures. Motor symptoms typically include myoclonus, tremor, and midline ataxia. DPPX encephalitis presenting as new-onset focal dystonia has not been previously described.
format Article
id doaj-art-a6312a498bf64f28be0ebe172aefab46
institution DOAJ
issn 2590-1125
language English
publishDate 2025-01-01
publisher Elsevier
record_format Article
series Clinical Parkinsonism & Related Disorders
spelling doaj-art-a6312a498bf64f28be0ebe172aefab462025-08-20T03:04:47ZengElsevierClinical Parkinsonism & Related Disorders2590-11252025-01-011210032010.1016/j.prdoa.2025.100320Anti-dipeptidyl-peptidase-like protein-6 (DPPX) autoimmune encephalitis associated with severe multifocal dystoniaEric Roddy0Erik Gentry1Victoria Holiday2David Robertson3Peter Hedera4University of Louisville School of Medicine, Department of Neurology, USAUniversity of Louisville School of Medicine, Department of Neurology, USAUniversity of Louisville School of Medicine, Department of Neurology, USANorton Neuroscience Institute, Department of Neurology, University of Louisville, 220, Abraham Flexner Way, Suite 606, USAUniversity of Louisville School of Medicine, Department of Neurology, USA; Corresponding author.Anti-DPPX encephalitis is a rare form of autoimmune encephalitis characterized antibodies against a subunit of Kv4.2 potassium channels. Characteristic clinical features include cognitive dysfunction, parasomnias, psychosis, and seizures. Motor symptoms typically include myoclonus, tremor, and midline ataxia. DPPX encephalitis presenting as new-onset focal dystonia has not been previously described.http://www.sciencedirect.com/science/article/pii/S2590112525000246DystoniaAutoimmune encephalitisDPPXImmunotherapyToxin therapy
spellingShingle Eric Roddy
Erik Gentry
Victoria Holiday
David Robertson
Peter Hedera
Anti-dipeptidyl-peptidase-like protein-6 (DPPX) autoimmune encephalitis associated with severe multifocal dystonia
Clinical Parkinsonism & Related Disorders
Dystonia
Autoimmune encephalitis
DPPX
Immunotherapy
Toxin therapy
title Anti-dipeptidyl-peptidase-like protein-6 (DPPX) autoimmune encephalitis associated with severe multifocal dystonia
title_full Anti-dipeptidyl-peptidase-like protein-6 (DPPX) autoimmune encephalitis associated with severe multifocal dystonia
title_fullStr Anti-dipeptidyl-peptidase-like protein-6 (DPPX) autoimmune encephalitis associated with severe multifocal dystonia
title_full_unstemmed Anti-dipeptidyl-peptidase-like protein-6 (DPPX) autoimmune encephalitis associated with severe multifocal dystonia
title_short Anti-dipeptidyl-peptidase-like protein-6 (DPPX) autoimmune encephalitis associated with severe multifocal dystonia
title_sort anti dipeptidyl peptidase like protein 6 dppx autoimmune encephalitis associated with severe multifocal dystonia
topic Dystonia
Autoimmune encephalitis
DPPX
Immunotherapy
Toxin therapy
url http://www.sciencedirect.com/science/article/pii/S2590112525000246
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