Surface-elastic hydrogels delay senescence via the modulation of redox homeostasis and cytoskeletal tension

Abstract The Bone marrow-derived mesenchymal stem cells (MSCs) are widely used in clinical applications owing to their therapeutic properties. However, in vitro expansion of MSCs in tissue culture dishes induces aging, which reduces their quality through an undefined mechanism. This study delineates...

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Bibliographic Details
Main Authors: Thasaneeya Kuboki, Satoru Kidoaki
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-04779-7
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