Electrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions
Abstract An electrochemical Meerwein arylation reaction was reported for the synthesis of aryl-benzoquinone derivatives. In this work, efficient electrochemical synthesis of aryl-benzoquinone derivatives by direct electrolysis of aqueous solution containing hydroquinone and aryldiazonium salts in ba...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-02504-y |
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| author | Mozhdeh Malmir Davood Nematollahi Ali Sadatnabi Sajad Shanehsaz |
| author_facet | Mozhdeh Malmir Davood Nematollahi Ali Sadatnabi Sajad Shanehsaz |
| author_sort | Mozhdeh Malmir |
| collection | DOAJ |
| description | Abstract An electrochemical Meerwein arylation reaction was reported for the synthesis of aryl-benzoquinone derivatives. In this work, efficient electrochemical synthesis of aryl-benzoquinone derivatives by direct electrolysis of aqueous solution containing hydroquinone and aryldiazonium salts in batch and a homemade continuous-flow cells is reported. In the batch system, the products were obtained in a simple undivided cell equipped with a copper anode and a stainless steel cathode. In the continuous flow system, the products were obtained simply by passing hydroquinone and the aryldiazonium salt through a tube made of copper with a stainless steel rod in the center. All equipment required in both cell types is obtained from common commercial sources. This protocol is green and cost-effective due to the use of electricity and is performed under mild and safe conditions without the use of toxic solvents and catalysts. |
| format | Article |
| id | doaj-art-a627f6b21fdb4ce590decd004f46a7ef |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-a627f6b21fdb4ce590decd004f46a7ef2025-08-20T03:10:18ZengNature PortfolioScientific Reports2045-23222025-05-0115111410.1038/s41598-025-02504-yElectrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditionsMozhdeh Malmir0Davood Nematollahi1Ali Sadatnabi2Sajad Shanehsaz3Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityFaculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityFaculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityFaculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityAbstract An electrochemical Meerwein arylation reaction was reported for the synthesis of aryl-benzoquinone derivatives. In this work, efficient electrochemical synthesis of aryl-benzoquinone derivatives by direct electrolysis of aqueous solution containing hydroquinone and aryldiazonium salts in batch and a homemade continuous-flow cells is reported. In the batch system, the products were obtained in a simple undivided cell equipped with a copper anode and a stainless steel cathode. In the continuous flow system, the products were obtained simply by passing hydroquinone and the aryldiazonium salt through a tube made of copper with a stainless steel rod in the center. All equipment required in both cell types is obtained from common commercial sources. This protocol is green and cost-effective due to the use of electricity and is performed under mild and safe conditions without the use of toxic solvents and catalysts.https://doi.org/10.1038/s41598-025-02504-yAryldiazonium saltContinuous-flow cellCopper anodeCyclic voltammetryHydroquinone |
| spellingShingle | Mozhdeh Malmir Davood Nematollahi Ali Sadatnabi Sajad Shanehsaz Electrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions Scientific Reports Aryldiazonium salt Continuous-flow cell Copper anode Cyclic voltammetry Hydroquinone |
| title | Electrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions |
| title_full | Electrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions |
| title_fullStr | Electrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions |
| title_full_unstemmed | Electrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions |
| title_short | Electrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions |
| title_sort | electrochemically induced meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions |
| topic | Aryldiazonium salt Continuous-flow cell Copper anode Cyclic voltammetry Hydroquinone |
| url | https://doi.org/10.1038/s41598-025-02504-y |
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