Identification of Anti-Inflammatory Components from <i>Launaea sarmentosa</i> Using <i>In Vitro</i> Cell Model
Launaea sarmentosa (Willd.) Kuntze, a medicinal herb known for treating inflammatory diseases, was examined for its anti-inflammatory compounds to identify novel therapies. This study indicated that hexane and ethyl acetate fractional extracts significantly reduced NO secretion in LPS-stimulated RAW...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Department of Chemistry, Universitas Gadjah Mada
2025-07-01
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| Series: | Indonesian Journal of Chemistry |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/103167 |
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| Summary: | Launaea sarmentosa (Willd.) Kuntze, a medicinal herb known for treating inflammatory diseases, was examined for its anti-inflammatory compounds to identify novel therapies. This study indicated that hexane and ethyl acetate fractional extracts significantly reduced NO secretion in LPS-stimulated RAW264.7 macrophages, indicating the presence of potential anti-inflammatory compounds. Additionally, four anti-inflammatory compounds, including taraxasteryl acetate (1), esculetin (2), pyrimidine-2,4-dione (3), and 5-hydroxypryrolidin-2-one (4), were isolated, and their structures were characterized using 1D and 2D-NMR. This study marked the first report of taraxasteryl acetate, pyrimidine-2,4-dione, and 5-hydroxypryrolidin-2-one being isolated from this species. Furthermore, these compounds exerted their anti-inflammatory role by inhibiting NO production and TNF-α expression. Thus, this study contributes to identifying anti-inflammatory constituents from L. sarmentosa and highlights a potential approach for developing phytotherapeutic agents. |
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| ISSN: | 1411-9420 2460-1578 |