Protective effects of lemon and orange peels and olive oil on doxorubicin-induced myocardial damage via inhibition of oxidative stress and inflammation pathways

Protective effects of lemon and orange peels and olive oil on doxorubicin-induced myocardial damage via inhibition of oxidative stress and inflammation pathways

Background/aimCompounds originating from plants, especially citrus fruits and olive oil, have anti-inflammatory, cardioprotective, and antioxidant characteristics. Doxorubicin (DOX), an anthracycline antineoplastic, induces cardiotoxicity by generating free radicals. This study aimed to evaluate the...

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Bibliographic Details
Main Authors: Amal I. El-Refaiy, Zainab A. Salem, Abdelnaser A. Badawy, Naief Dahran, Muhammad A. Desouky, Mohammed A. El-Magd
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
Doxorubicin
cardiomyocyte
citrus peels
olive oil
rats
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1506673/full
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