Diagnostic and prognostic value of autoantibodies for diabetes mellitus. A novel T1D autoimmunity target - zinc transporter 8 (ZnT8)
The progressive loss of beta cells in Type 1 Diabetes (T1D) is a result of chronic autoimmune attack targeted at diverse molecules expressing in thepancreatic beta cells. The appearance of cellular and humoral autoimmunity precedes the clinical manifestation of T1D. There are several autoantigenswhi...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2011-06-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/5629 |
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| author | Olga Sergeevna Shapoval'yants Tatiana Vasil'evna Nikonova |
| author_facet | Olga Sergeevna Shapoval'yants Tatiana Vasil'evna Nikonova |
| author_sort | Olga Sergeevna Shapoval'yants |
| collection | DOAJ |
| description | The progressive loss of beta cells in Type 1 Diabetes (T1D) is a result of chronic autoimmune attack targeted at diverse molecules expressing in thepancreatic beta cells. The appearance of cellular and humoral autoimmunity precedes the clinical manifestation of T1D. There are several autoantigenswhich are supposed to be involved in pathogenesis of TD1. Zinc transporter 8 (ZnT8; Slc30A8) was identified as a novel T1D autoimmunitytarget. |
| format | Article |
| id | doaj-art-a6218a47bb0248d9a764e34efe43e3ad |
| institution | OA Journals |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2011-06-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-a6218a47bb0248d9a764e34efe43e3ad2025-08-20T01:57:09ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782011-06-01142182210.14341/2072-0351-56295587Diagnostic and prognostic value of autoantibodies for diabetes mellitus. A novel T1D autoimmunity target - zinc transporter 8 (ZnT8)Olga Sergeevna Shapoval'yants0Tatiana Vasil'evna Nikonova1Endocrinological Research Centre, MoscowEndocrinological Research Centre, MoscowThe progressive loss of beta cells in Type 1 Diabetes (T1D) is a result of chronic autoimmune attack targeted at diverse molecules expressing in thepancreatic beta cells. The appearance of cellular and humoral autoimmunity precedes the clinical manifestation of T1D. There are several autoantigenswhich are supposed to be involved in pathogenesis of TD1. Zinc transporter 8 (ZnT8; Slc30A8) was identified as a novel T1D autoimmunitytarget.https://www.dia-endojournals.ru/jour/article/view/5629type 1 mellitus diabetesautoantibodiesimmunnityzinc transporter 8 |
| spellingShingle | Olga Sergeevna Shapoval'yants Tatiana Vasil'evna Nikonova Diagnostic and prognostic value of autoantibodies for diabetes mellitus. A novel T1D autoimmunity target - zinc transporter 8 (ZnT8) Сахарный диабет type 1 mellitus diabetes autoantibodies immunnity zinc transporter 8 |
| title | Diagnostic and prognostic value of autoantibodies for diabetes mellitus. A novel T1D autoimmunity target - zinc transporter 8 (ZnT8) |
| title_full | Diagnostic and prognostic value of autoantibodies for diabetes mellitus. A novel T1D autoimmunity target - zinc transporter 8 (ZnT8) |
| title_fullStr | Diagnostic and prognostic value of autoantibodies for diabetes mellitus. A novel T1D autoimmunity target - zinc transporter 8 (ZnT8) |
| title_full_unstemmed | Diagnostic and prognostic value of autoantibodies for diabetes mellitus. A novel T1D autoimmunity target - zinc transporter 8 (ZnT8) |
| title_short | Diagnostic and prognostic value of autoantibodies for diabetes mellitus. A novel T1D autoimmunity target - zinc transporter 8 (ZnT8) |
| title_sort | diagnostic and prognostic value of autoantibodies for diabetes mellitus a novel t1d autoimmunity target zinc transporter 8 znt8 |
| topic | type 1 mellitus diabetes autoantibodies immunnity zinc transporter 8 |
| url | https://www.dia-endojournals.ru/jour/article/view/5629 |
| work_keys_str_mv | AT olgasergeevnashapovalyants diagnosticandprognosticvalueofautoantibodiesfordiabetesmellitusanovelt1dautoimmunitytargetzinctransporter8znt8 AT tatianavasilevnanikonova diagnosticandprognosticvalueofautoantibodiesfordiabetesmellitusanovelt1dautoimmunitytargetzinctransporter8znt8 |