Targeting insulin-like growth factor 1 receptor restricts development and severity of secondary lymphedema in mice

Summary: Secondary lymphedema is a debilitating chronic tissue swelling in a limb caused by inadequate interstitial fluid drainage due to dysfunctional lymphatic vessels. Pathological enlargement of small lymphatics contributes to lymphatic dysfunction in secondary lymphedema, but molecular mechanis...

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Bibliographic Details
Main Authors: Yinan Yuan, Sidney M. Levy, Yong Qiang Yeo, Ramin Shayan, Tara Karnezis, Steven A. Stacker, Marc G. Achen
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:iScience
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Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225002081
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