hAMSC Sheet Promotes Repair of Rabbit Osteochondral Defects
Osteochondral lesion is clinically common disease, which has been recognized as one of the contributing factors of significant morbidity. Although current treatments have achieved good outcomes, some undesirable complications and failures are not uncommon. Cell sheet technology (CST), an innovative...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2022/3967722 |
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| _version_ | 1849397959985201152 |
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| author | Gang Zou Jun Zhang Qifan Yang Xiaoyan Wang Pengpeng Sun |
| author_facet | Gang Zou Jun Zhang Qifan Yang Xiaoyan Wang Pengpeng Sun |
| author_sort | Gang Zou |
| collection | DOAJ |
| description | Osteochondral lesion is clinically common disease, which has been recognized as one of the contributing factors of significant morbidity. Although current treatments have achieved good outcomes, some undesirable complications and failures are not uncommon. Cell sheet technology (CST), an innovative technology to harvest seed cells and preserve abundant ECM, has been widely used in various tissue regeneration. For osteochondral lesion, many studies focus on using CST to repair osteochondral lesion and have achieved good outcomes. In the previous study, we have demonstrated that hAMSC sheet had a positive effect on osteochondral lesion. Therefore, this study is aimed at comparing the effect of noninduced hAMSC sheet with chondrogenically induced hAMSC sheet on osteochondral lesion and cartilage regeneration. |
| format | Article |
| id | doaj-art-a6097891cfec4d1cb8d4375c120b416a |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-a6097891cfec4d1cb8d4375c120b416a2025-08-20T03:38:48ZengWileyStem Cells International1687-96782022-01-01202210.1155/2022/3967722hAMSC Sheet Promotes Repair of Rabbit Osteochondral DefectsGang Zou0Jun Zhang1Qifan Yang2Xiaoyan Wang3Pengpeng Sun4Department of Orthopaedic SurgeryDepartment of OrthopedicsDepartment of Orthopaedic SurgeryDepartment of Obstetrics and GynecologyDepartment of Orthopaedic SurgeryOsteochondral lesion is clinically common disease, which has been recognized as one of the contributing factors of significant morbidity. Although current treatments have achieved good outcomes, some undesirable complications and failures are not uncommon. Cell sheet technology (CST), an innovative technology to harvest seed cells and preserve abundant ECM, has been widely used in various tissue regeneration. For osteochondral lesion, many studies focus on using CST to repair osteochondral lesion and have achieved good outcomes. In the previous study, we have demonstrated that hAMSC sheet had a positive effect on osteochondral lesion. Therefore, this study is aimed at comparing the effect of noninduced hAMSC sheet with chondrogenically induced hAMSC sheet on osteochondral lesion and cartilage regeneration.http://dx.doi.org/10.1155/2022/3967722 |
| spellingShingle | Gang Zou Jun Zhang Qifan Yang Xiaoyan Wang Pengpeng Sun hAMSC Sheet Promotes Repair of Rabbit Osteochondral Defects Stem Cells International |
| title | hAMSC Sheet Promotes Repair of Rabbit Osteochondral Defects |
| title_full | hAMSC Sheet Promotes Repair of Rabbit Osteochondral Defects |
| title_fullStr | hAMSC Sheet Promotes Repair of Rabbit Osteochondral Defects |
| title_full_unstemmed | hAMSC Sheet Promotes Repair of Rabbit Osteochondral Defects |
| title_short | hAMSC Sheet Promotes Repair of Rabbit Osteochondral Defects |
| title_sort | hamsc sheet promotes repair of rabbit osteochondral defects |
| url | http://dx.doi.org/10.1155/2022/3967722 |
| work_keys_str_mv | AT gangzou hamscsheetpromotesrepairofrabbitosteochondraldefects AT junzhang hamscsheetpromotesrepairofrabbitosteochondraldefects AT qifanyang hamscsheetpromotesrepairofrabbitosteochondraldefects AT xiaoyanwang hamscsheetpromotesrepairofrabbitosteochondraldefects AT pengpengsun hamscsheetpromotesrepairofrabbitosteochondraldefects |