MELATONIN CAN NOT SIGNIFICANTLY REDUCE BLOOD SUGAR LEVELS
Abstract Background: Burn are trauma that can cause local and systemic damage including hypermetabolism, inflammation, and hyperglicemia. Stress Induced Hyperglycemia (SIH) occurs by increasing gluconeogenesis and insulin resistance. Both of these are mediated through an increase in regulated stres...
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Faculty of Medicine, Universitas Diponegoro
2021-07-01
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| Series: | Jurnal Kedokteran Diponegoro |
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| Online Access: | https://ejournal3.undip.ac.id/index.php/medico/article/view/29491 |
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| author | Christiana Rinalda Taufik Eko Nugroho Lusiana Batubara Asih Budiastuti |
| author_facet | Christiana Rinalda Taufik Eko Nugroho Lusiana Batubara Asih Budiastuti |
| author_sort | Christiana Rinalda |
| collection | DOAJ |
| description | Abstract
Background: Burn are trauma that can cause local and systemic damage including hypermetabolism, inflammation, and hyperglicemia. Stress Induced Hyperglycemia (SIH) occurs by increasing gluconeogenesis and insulin resistance. Both of these are mediated through an increase in regulated stress hormones and proinflammatory cytokines. Melatonin has been proposed as a burn supportive therapy that may prevent oxidative damage and inhibit excessive inflammatory responses.
Aim: Proving the effects of melatonin supplementation on blood glucose level in male Wistar rats with burn injury.
Methods: This research was an experimental with randomized control group pre-post test design. Twelve healthy male Wistar rats were included and divided into two groups, control and experimental group. Each rat was induced 30% burn injury under anesthesia. Rats in control group were given placebo, while rats in experimental group were treated with melatonin i.p at 0, 8 and 16 hours after burn injury. Blood samples were collected from the retroorbital sinuses at 0, 3, and 24 hours. Data were analyzed statistically by Paired t-Test and Independent t-Test.
Results: In male Wistar rats with third degree burns given placebo, blood sugar levels significantly increase in 0-3 hours (p=0.006) and 0-24 hours (p=0.037). Meanwhile, in male Wistar rats with third degree burns given melatonin, blood sugar levels did not change significantly in 0-3 hours (p=0.470), 0-24 hours (p=0.286), dan 3-24 hours (p=0.833).
Conclusions: Melatonin administration can not significantly reduce blood sugar levels.
Keywords: Burn, burn injury, blood glucose level, melatonin. |
| format | Article |
| id | doaj-art-a5feaec7f4934866a110bb52544c1b4d |
| institution | OA Journals |
| issn | 2540-8844 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Faculty of Medicine, Universitas Diponegoro |
| record_format | Article |
| series | Jurnal Kedokteran Diponegoro |
| spelling | doaj-art-a5feaec7f4934866a110bb52544c1b4d2025-08-20T02:20:44ZengFaculty of Medicine, Universitas DiponegoroJurnal Kedokteran Diponegoro2540-88442021-07-0110423424010.14710/dmj.v10i4.2949126617MELATONIN CAN NOT SIGNIFICANTLY REDUCE BLOOD SUGAR LEVELSChristiana Rinalda0Taufik Eko Nugroho1Lusiana Batubara2Asih Budiastuti3Department of Medicine, Faculty of Medicine Diponegoro University Semarang, IndonesiaDept of Anesthesia, Faculty of Medicine Diponegoro University Semarang, IndonesiaDept of Medical Biology and Biochemistry Faculty of Medicine Diponegoro University Semarang, IndonesiaDept of Dermatovenerology Faculty of Medicine Diponegoro University Semarang, IndonesiaAbstract Background: Burn are trauma that can cause local and systemic damage including hypermetabolism, inflammation, and hyperglicemia. Stress Induced Hyperglycemia (SIH) occurs by increasing gluconeogenesis and insulin resistance. Both of these are mediated through an increase in regulated stress hormones and proinflammatory cytokines. Melatonin has been proposed as a burn supportive therapy that may prevent oxidative damage and inhibit excessive inflammatory responses. Aim: Proving the effects of melatonin supplementation on blood glucose level in male Wistar rats with burn injury. Methods: This research was an experimental with randomized control group pre-post test design. Twelve healthy male Wistar rats were included and divided into two groups, control and experimental group. Each rat was induced 30% burn injury under anesthesia. Rats in control group were given placebo, while rats in experimental group were treated with melatonin i.p at 0, 8 and 16 hours after burn injury. Blood samples were collected from the retroorbital sinuses at 0, 3, and 24 hours. Data were analyzed statistically by Paired t-Test and Independent t-Test. Results: In male Wistar rats with third degree burns given placebo, blood sugar levels significantly increase in 0-3 hours (p=0.006) and 0-24 hours (p=0.037). Meanwhile, in male Wistar rats with third degree burns given melatonin, blood sugar levels did not change significantly in 0-3 hours (p=0.470), 0-24 hours (p=0.286), dan 3-24 hours (p=0.833). Conclusions: Melatonin administration can not significantly reduce blood sugar levels. Keywords: Burn, burn injury, blood glucose level, melatonin.https://ejournal3.undip.ac.id/index.php/medico/article/view/29491burn, burn injury, blood glucose level, melatonin. |
| spellingShingle | Christiana Rinalda Taufik Eko Nugroho Lusiana Batubara Asih Budiastuti MELATONIN CAN NOT SIGNIFICANTLY REDUCE BLOOD SUGAR LEVELS Jurnal Kedokteran Diponegoro burn, burn injury, blood glucose level, melatonin. |
| title | MELATONIN CAN NOT SIGNIFICANTLY REDUCE BLOOD SUGAR LEVELS |
| title_full | MELATONIN CAN NOT SIGNIFICANTLY REDUCE BLOOD SUGAR LEVELS |
| title_fullStr | MELATONIN CAN NOT SIGNIFICANTLY REDUCE BLOOD SUGAR LEVELS |
| title_full_unstemmed | MELATONIN CAN NOT SIGNIFICANTLY REDUCE BLOOD SUGAR LEVELS |
| title_short | MELATONIN CAN NOT SIGNIFICANTLY REDUCE BLOOD SUGAR LEVELS |
| title_sort | melatonin can not significantly reduce blood sugar levels |
| topic | burn, burn injury, blood glucose level, melatonin. |
| url | https://ejournal3.undip.ac.id/index.php/medico/article/view/29491 |
| work_keys_str_mv | AT christianarinalda melatonincannotsignificantlyreducebloodsugarlevels AT taufikekonugroho melatonincannotsignificantlyreducebloodsugarlevels AT lusianabatubara melatonincannotsignificantlyreducebloodsugarlevels AT asihbudiastuti melatonincannotsignificantlyreducebloodsugarlevels |