The use of darbepoetin alpha in infants
Among the somatic pathology in young children, the most common is anemic syndrome. Until recently, the commonest method for correction of anemia was hemotransfusion, which allows to restore normal hemoglobin quickly, but has the high risk of complications. The main disadvantage of this method is the...
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| Format: | Article |
| Language: | Russian |
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Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
2019-06-01
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| Series: | Сеченовский вестник |
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| Online Access: | https://www.sechenovmedj.com/jour/article/view/105 |
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| author | A. V. Shchegolev G. Z. Sufianova A. A. Sufianov N. E. Ivanova M. S. Khlestkina |
| author_facet | A. V. Shchegolev G. Z. Sufianova A. A. Sufianov N. E. Ivanova M. S. Khlestkina |
| author_sort | A. V. Shchegolev |
| collection | DOAJ |
| description | Among the somatic pathology in young children, the most common is anemic syndrome. Until recently, the commonest method for correction of anemia was hemotransfusion, which allows to restore normal hemoglobin quickly, but has the high risk of complications. The main disadvantage of this method is the short - term positive effect and necessity of repeating donor red blood cell transfusions to prevent rapid progression of anemia. The currently available alternative is the use of an erythropoiesis - stimulating agent, which increases the level of hemoglobin and red blood cells in the blood by stimulating of erythropoiesis in the bone marrow. Modern erythropoiesis - stimulating agent and anti - anemic drug, registered in Russian Federation, is darbepoetin alpha. When developing this drug, a new approach was used to increase the number of sialic acid residues and the degree of glycolysis. This helped to achieve an optimal ratio between the activity and the half - life period of the drug and made possible to prescribe it with longer intervals between injections. Currently, there is evidence of effective and safe use of darbepoetin alpha in premature infants with low body weight, anemia, encephalopathy and chronic kidney disease. |
| format | Article |
| id | doaj-art-a5fc19c09ad74639b9b48eec869210d3 |
| institution | DOAJ |
| issn | 2218-7332 2658-3348 |
| language | Russian |
| publishDate | 2019-06-01 |
| publisher | Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University) |
| record_format | Article |
| series | Сеченовский вестник |
| spelling | doaj-art-a5fc19c09ad74639b9b48eec869210d32025-08-20T02:53:22ZrusFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)Сеченовский вестник2218-73322658-33482019-06-01102636910.47093/22187332.2019.2.63-69104The use of darbepoetin alpha in infantsA. V. Shchegolev0G. Z. Sufianova1A. A. Sufianov2N. E. Ivanova3M. S. Khlestkina4Military Medical AcademyTyumen State Medical UniversityFederal Center of Neurosurgery; Sechenov First Moscow State Medical University (Sechenov University)Federal Center of NeurosurgeryTyumen State Medical University; Federal Center of NeurosurgeryAmong the somatic pathology in young children, the most common is anemic syndrome. Until recently, the commonest method for correction of anemia was hemotransfusion, which allows to restore normal hemoglobin quickly, but has the high risk of complications. The main disadvantage of this method is the short - term positive effect and necessity of repeating donor red blood cell transfusions to prevent rapid progression of anemia. The currently available alternative is the use of an erythropoiesis - stimulating agent, which increases the level of hemoglobin and red blood cells in the blood by stimulating of erythropoiesis in the bone marrow. Modern erythropoiesis - stimulating agent and anti - anemic drug, registered in Russian Federation, is darbepoetin alpha. When developing this drug, a new approach was used to increase the number of sialic acid residues and the degree of glycolysis. This helped to achieve an optimal ratio between the activity and the half - life period of the drug and made possible to prescribe it with longer intervals between injections. Currently, there is evidence of effective and safe use of darbepoetin alpha in premature infants with low body weight, anemia, encephalopathy and chronic kidney disease.https://www.sechenovmedj.com/jour/article/view/105anemiaerythropoiesisdarbepoetin alfapediatricsinfantspremature infants |
| spellingShingle | A. V. Shchegolev G. Z. Sufianova A. A. Sufianov N. E. Ivanova M. S. Khlestkina The use of darbepoetin alpha in infants Сеченовский вестник anemia erythropoiesis darbepoetin alfa pediatrics infants premature infants |
| title | The use of darbepoetin alpha in infants |
| title_full | The use of darbepoetin alpha in infants |
| title_fullStr | The use of darbepoetin alpha in infants |
| title_full_unstemmed | The use of darbepoetin alpha in infants |
| title_short | The use of darbepoetin alpha in infants |
| title_sort | use of darbepoetin alpha in infants |
| topic | anemia erythropoiesis darbepoetin alfa pediatrics infants premature infants |
| url | https://www.sechenovmedj.com/jour/article/view/105 |
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