Accuracy of capillary blood sampling for diagnosing syphilis infection
Abstract Capillary blood collection presents advantages such as reduced invasiveness over venous serum for syphilis diagnosing. This study aimed to compare diagnostic accuracy between capillary and venous blood samples for syphilis diagnosis. Individuals aged ≥ 18 years were included in a cross-sect...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-88329-1 |
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| author | Aniúsca Vieira dos Santos Ana Carolina Monteiro da Rocha Giovana Tavares dos Santos Igor Araujo Vieira Cáren Nunes de Oliveira Suelen Basgalupp Luana Giongo Pedrotti Vinicius Serafini Roglio Emerson Silveira de Brito Thayane Martins Dornelles Gerson Fernando Mendes Pereira Flávia Moreno Alves de Souza Eliana Marcia Wendland |
| author_facet | Aniúsca Vieira dos Santos Ana Carolina Monteiro da Rocha Giovana Tavares dos Santos Igor Araujo Vieira Cáren Nunes de Oliveira Suelen Basgalupp Luana Giongo Pedrotti Vinicius Serafini Roglio Emerson Silveira de Brito Thayane Martins Dornelles Gerson Fernando Mendes Pereira Flávia Moreno Alves de Souza Eliana Marcia Wendland |
| author_sort | Aniúsca Vieira dos Santos |
| collection | DOAJ |
| description | Abstract Capillary blood collection presents advantages such as reduced invasiveness over venous serum for syphilis diagnosing. This study aimed to compare diagnostic accuracy between capillary and venous blood samples for syphilis diagnosis. Individuals aged ≥ 18 years were included in a cross-sectional study. Syphilis screening was done using Rapid tests (RT) followed by collection of serum capillary and venous samples for VDRL and TPHA test. Sensitivity, specificity, and Kappa coefficient were calculated. Of 191 participants, 115 RT + and 76 RT-. Diagnostic properties did not significantly differ between capillary and venous samples. Capillary VDRL showed 99% sensitivity and 100% specificity, mirroring TPHA results. Furthermore, there was significant agreement between sample types for both serological tests (p < 0.001). Capillary sampling offers comparable diagnostic accuracy to venous collection, regardless of serum quality. Capillary sampling holds promise, particularly in developing countries and large-scale testing initiatives. |
| format | Article |
| id | doaj-art-a5eec852d0074bc18d6a75451c3474b3 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-a5eec852d0074bc18d6a75451c3474b32025-08-20T02:48:29ZengNature PortfolioScientific Reports2045-23222025-02-011511810.1038/s41598-025-88329-1Accuracy of capillary blood sampling for diagnosing syphilis infectionAniúsca Vieira dos Santos0Ana Carolina Monteiro da Rocha1Giovana Tavares dos Santos2Igor Araujo Vieira3Cáren Nunes de Oliveira4Suelen Basgalupp5Luana Giongo Pedrotti6Vinicius Serafini Roglio7Emerson Silveira de Brito8 Thayane Martins Dornelles9Gerson Fernando Mendes Pereira10Flávia Moreno Alves de Souza11Eliana Marcia Wendland12Hospital Moinhos de Vento, PROADI – SUSHospital Moinhos de Vento, PROADI – SUSHospital Moinhos de Vento, PROADI – SUSHospital Moinhos de Vento, PROADI – SUSHospital Moinhos de Vento, PROADI – SUSHospital Moinhos de Vento, PROADI – SUSHospital Moinhos de Vento, PROADI – SUSHospital Moinhos de Vento, PROADI – SUSHospital Moinhos de Vento, PROADI – SUSHospital Moinhos de Vento, PROADI – SUSDepartment of HIV/AIDS, Viral Hepatitis and Sexually Transmitted Infections (DATHI),, Ministry of HealthDepartment of HIV/AIDS, Viral Hepatitis and Sexually Transmitted Infections (DATHI),, Ministry of HealthHospital Moinhos de Vento, PROADI – SUSAbstract Capillary blood collection presents advantages such as reduced invasiveness over venous serum for syphilis diagnosing. This study aimed to compare diagnostic accuracy between capillary and venous blood samples for syphilis diagnosis. Individuals aged ≥ 18 years were included in a cross-sectional study. Syphilis screening was done using Rapid tests (RT) followed by collection of serum capillary and venous samples for VDRL and TPHA test. Sensitivity, specificity, and Kappa coefficient were calculated. Of 191 participants, 115 RT + and 76 RT-. Diagnostic properties did not significantly differ between capillary and venous samples. Capillary VDRL showed 99% sensitivity and 100% specificity, mirroring TPHA results. Furthermore, there was significant agreement between sample types for both serological tests (p < 0.001). Capillary sampling offers comparable diagnostic accuracy to venous collection, regardless of serum quality. Capillary sampling holds promise, particularly in developing countries and large-scale testing initiatives.https://doi.org/10.1038/s41598-025-88329-1SyphilisBlood specimen collectionsSerologic tests |
| spellingShingle | Aniúsca Vieira dos Santos Ana Carolina Monteiro da Rocha Giovana Tavares dos Santos Igor Araujo Vieira Cáren Nunes de Oliveira Suelen Basgalupp Luana Giongo Pedrotti Vinicius Serafini Roglio Emerson Silveira de Brito Thayane Martins Dornelles Gerson Fernando Mendes Pereira Flávia Moreno Alves de Souza Eliana Marcia Wendland Accuracy of capillary blood sampling for diagnosing syphilis infection Scientific Reports Syphilis Blood specimen collections Serologic tests |
| title | Accuracy of capillary blood sampling for diagnosing syphilis infection |
| title_full | Accuracy of capillary blood sampling for diagnosing syphilis infection |
| title_fullStr | Accuracy of capillary blood sampling for diagnosing syphilis infection |
| title_full_unstemmed | Accuracy of capillary blood sampling for diagnosing syphilis infection |
| title_short | Accuracy of capillary blood sampling for diagnosing syphilis infection |
| title_sort | accuracy of capillary blood sampling for diagnosing syphilis infection |
| topic | Syphilis Blood specimen collections Serologic tests |
| url | https://doi.org/10.1038/s41598-025-88329-1 |
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