Adaptation in human immune cells residing in tissues at the frontline of infections
Abstract Human immune cells are under constant evolutionary pressure, primarily through their role as first line of defence against pathogens. Most studies on immune adaptation are, however, based on protein-coding genes without considering their cellular context. Here, using data from the Human Cel...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54603-5 |
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| author | Irepan Salvador-Martínez Jesus Murga-Moreno Juan C. Nieto Clara Alsinet David Enard Holger Heyn |
| author_facet | Irepan Salvador-Martínez Jesus Murga-Moreno Juan C. Nieto Clara Alsinet David Enard Holger Heyn |
| author_sort | Irepan Salvador-Martínez |
| collection | DOAJ |
| description | Abstract Human immune cells are under constant evolutionary pressure, primarily through their role as first line of defence against pathogens. Most studies on immune adaptation are, however, based on protein-coding genes without considering their cellular context. Here, using data from the Human Cell Atlas, we infer the gene adaptation rate of the human immune landscape at cellular resolution. We find abundant cell types, like progenitor cells during development and adult cells in barrier tissues, to harbour significantly increased adaptation rates. We confirm the adaptation of tissue-resident T and NK cells in the adult lung located in compartments directly facing external challenges, such as respiratory pathogens. Analysing human iPSC-derived macrophages responding to various challenges, we find adaptation in early immune responses. Together, our study suggests host benefits to control pathogen spread at early stages of infection, providing a retrospect of forces that shaped the complexity, architecture, and function of the human body. |
| format | Article |
| id | doaj-art-a5ee579328c6429ea1cc1477e98c2c7b |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-a5ee579328c6429ea1cc1477e98c2c7b2025-08-20T02:08:20ZengNature PortfolioNature Communications2041-17232024-11-0115111510.1038/s41467-024-54603-5Adaptation in human immune cells residing in tissues at the frontline of infectionsIrepan Salvador-Martínez0Jesus Murga-Moreno1Juan C. Nieto2Clara Alsinet3David Enard4Holger Heyn5CNAG, Centro Nacional de Análisis GenómicoDepartment of Ecology and Evolutionary Biology, University of ArizonaCNAG, Centro Nacional de Análisis GenómicoCNAG, Centro Nacional de Análisis GenómicoDepartment of Ecology and Evolutionary Biology, University of ArizonaCNAG, Centro Nacional de Análisis GenómicoAbstract Human immune cells are under constant evolutionary pressure, primarily through their role as first line of defence against pathogens. Most studies on immune adaptation are, however, based on protein-coding genes without considering their cellular context. Here, using data from the Human Cell Atlas, we infer the gene adaptation rate of the human immune landscape at cellular resolution. We find abundant cell types, like progenitor cells during development and adult cells in barrier tissues, to harbour significantly increased adaptation rates. We confirm the adaptation of tissue-resident T and NK cells in the adult lung located in compartments directly facing external challenges, such as respiratory pathogens. Analysing human iPSC-derived macrophages responding to various challenges, we find adaptation in early immune responses. Together, our study suggests host benefits to control pathogen spread at early stages of infection, providing a retrospect of forces that shaped the complexity, architecture, and function of the human body.https://doi.org/10.1038/s41467-024-54603-5 |
| spellingShingle | Irepan Salvador-Martínez Jesus Murga-Moreno Juan C. Nieto Clara Alsinet David Enard Holger Heyn Adaptation in human immune cells residing in tissues at the frontline of infections Nature Communications |
| title | Adaptation in human immune cells residing in tissues at the frontline of infections |
| title_full | Adaptation in human immune cells residing in tissues at the frontline of infections |
| title_fullStr | Adaptation in human immune cells residing in tissues at the frontline of infections |
| title_full_unstemmed | Adaptation in human immune cells residing in tissues at the frontline of infections |
| title_short | Adaptation in human immune cells residing in tissues at the frontline of infections |
| title_sort | adaptation in human immune cells residing in tissues at the frontline of infections |
| url | https://doi.org/10.1038/s41467-024-54603-5 |
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