Terpenoids: A promising traditional chinese medicine for neuropathic pain relief
Neuropathic pain (NPP) is a prevalent chronic condition characterized by spontaneous pain, hyperalgesia, allodynia, and sensory abnormalities, severely impacting patients' quality of life. Despite various guided treatments, their clinical efficacy remains limited, often accompanied by adverse r...
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Elsevier
2025-06-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825002142 |
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| author | Hui-Si Yang David H. Mauki Yue-Xiang Zheng Ting-Hua Wang Xiu-Ying He |
| author_facet | Hui-Si Yang David H. Mauki Yue-Xiang Zheng Ting-Hua Wang Xiu-Ying He |
| author_sort | Hui-Si Yang |
| collection | DOAJ |
| description | Neuropathic pain (NPP) is a prevalent chronic condition characterized by spontaneous pain, hyperalgesia, allodynia, and sensory abnormalities, severely impacting patients' quality of life. Despite various guided treatments, their clinical efficacy remains limited, often accompanied by adverse reactions. Traditional Chinese medicine (TCM) offers unique advantages in disease treatment through its holistic approach (balancing the body as a unified system) and syndrome differentiation principle (personalized medicine). Recent research has highlighted terpenoids for their analgesic effects and minimal side effects. This review summarizes the role of terpenoids in NPP and their underlying molecular mechanisms. Terpenoids, natural products found in plants, are categorized into monoterpenoids, sesquiterpenoids, diterpenoids, triterpenoids, and tetraterpenoids based on isoprene units. These compounds alleviate NPP by: inhibiting neuroinflammation and oxidative stress, regulating mitochondrial function, modulating ion channels, and influencing the cannabinoid and opioid receptor systems. This review aims to deepen our understanding of terpenoids and provide crucial evidence and mechanistic insights for their application in NPP therapy. |
| format | Article |
| id | doaj-art-a5ed675bf48e4beab5dc8f43df5492dd |
| institution | OA Journals |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-a5ed675bf48e4beab5dc8f43df5492dd2025-08-20T02:32:20ZengElsevierPharmacological Research1096-11862025-06-0121610778910.1016/j.phrs.2025.107789Terpenoids: A promising traditional chinese medicine for neuropathic pain reliefHui-Si Yang0David H. Mauki1Yue-Xiang Zheng2Ting-Hua Wang3Xiu-Ying He4Department of Anesthesiology, Institute of Neurological Disease, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Department of Neurology and National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Anesthesiology, Institute of Neurological Disease, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurology and National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Anesthesiology, Institute of Neurological Disease, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Department of Neurology and National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China; Correspondence to: Department of Anesthesiology, Institute of Neurological Disease, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.Department of Anesthesiology, Institute of Neurological Disease, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Department of Neurology and National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China; Correspondence to: Department of Anesthesiology, Institute of Neurological Disease, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.Neuropathic pain (NPP) is a prevalent chronic condition characterized by spontaneous pain, hyperalgesia, allodynia, and sensory abnormalities, severely impacting patients' quality of life. Despite various guided treatments, their clinical efficacy remains limited, often accompanied by adverse reactions. Traditional Chinese medicine (TCM) offers unique advantages in disease treatment through its holistic approach (balancing the body as a unified system) and syndrome differentiation principle (personalized medicine). Recent research has highlighted terpenoids for their analgesic effects and minimal side effects. This review summarizes the role of terpenoids in NPP and their underlying molecular mechanisms. Terpenoids, natural products found in plants, are categorized into monoterpenoids, sesquiterpenoids, diterpenoids, triterpenoids, and tetraterpenoids based on isoprene units. These compounds alleviate NPP by: inhibiting neuroinflammation and oxidative stress, regulating mitochondrial function, modulating ion channels, and influencing the cannabinoid and opioid receptor systems. This review aims to deepen our understanding of terpenoids and provide crucial evidence and mechanistic insights for their application in NPP therapy.http://www.sciencedirect.com/science/article/pii/S1043661825002142TerpenoidsTraditional Chinese MedicineNeuropathic painAnalgesic |
| spellingShingle | Hui-Si Yang David H. Mauki Yue-Xiang Zheng Ting-Hua Wang Xiu-Ying He Terpenoids: A promising traditional chinese medicine for neuropathic pain relief Pharmacological Research Terpenoids Traditional Chinese Medicine Neuropathic pain Analgesic |
| title | Terpenoids: A promising traditional chinese medicine for neuropathic pain relief |
| title_full | Terpenoids: A promising traditional chinese medicine for neuropathic pain relief |
| title_fullStr | Terpenoids: A promising traditional chinese medicine for neuropathic pain relief |
| title_full_unstemmed | Terpenoids: A promising traditional chinese medicine for neuropathic pain relief |
| title_short | Terpenoids: A promising traditional chinese medicine for neuropathic pain relief |
| title_sort | terpenoids a promising traditional chinese medicine for neuropathic pain relief |
| topic | Terpenoids Traditional Chinese Medicine Neuropathic pain Analgesic |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825002142 |
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