Molecular Mechanisms and Clinical Aspects of Colitis-Associated Cancer in Ulcerative Colitis
Inflammatory bowel diseases have long been recognized as entities with a higher risk of colorectal cancer. An increasing amount of information has been published regarding ulcerative colitis-associated colorectal cancer and its unique mechanisms in recent decades, as ulcerative colitis constitutes a...
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2073-4409/14/3/162 |
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| author | Jesus K. Yamamoto-Furusho Fausto D. Gutierrez-Herrera |
| author_facet | Jesus K. Yamamoto-Furusho Fausto D. Gutierrez-Herrera |
| author_sort | Jesus K. Yamamoto-Furusho |
| collection | DOAJ |
| description | Inflammatory bowel diseases have long been recognized as entities with a higher risk of colorectal cancer. An increasing amount of information has been published regarding ulcerative colitis-associated colorectal cancer and its unique mechanisms in recent decades, as ulcerative colitis constitutes a chronic process characterized by cycles of activity and remission of unpredictable durations and intensities; cumulative genomic alterations occur during active disease and mucosal healing, resulting in a special sequence of events different to the events associated with sporadic colorectal cancer. The recognition of the core differences between sporadic colorectal cancer and colitis-associated cancer is of great importance to understand and guide the directions in which new research could be performed, and how it could be applied to current clinical scenarios. A DSS/AOM murine model has allowed for a better understanding of the pathogenic mechanisms in colitis-associated cancer, as it is currently the closest model to this unique scenario. In this review, we provide a summary of the main molecular mechanisms and the clinical aspects of colitis-associated cancer in ulcerative colitis. |
| format | Article |
| id | doaj-art-a5eaf1e6e4f343c991c2b40ae02cbeb5 |
| institution | DOAJ |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-a5eaf1e6e4f343c991c2b40ae02cbeb52025-08-20T02:48:06ZengMDPI AGCells2073-44092025-01-0114316210.3390/cells14030162Molecular Mechanisms and Clinical Aspects of Colitis-Associated Cancer in Ulcerative ColitisJesus K. Yamamoto-Furusho0Fausto D. Gutierrez-Herrera1Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de México 14080, MexicoInflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de México 14080, MexicoInflammatory bowel diseases have long been recognized as entities with a higher risk of colorectal cancer. An increasing amount of information has been published regarding ulcerative colitis-associated colorectal cancer and its unique mechanisms in recent decades, as ulcerative colitis constitutes a chronic process characterized by cycles of activity and remission of unpredictable durations and intensities; cumulative genomic alterations occur during active disease and mucosal healing, resulting in a special sequence of events different to the events associated with sporadic colorectal cancer. The recognition of the core differences between sporadic colorectal cancer and colitis-associated cancer is of great importance to understand and guide the directions in which new research could be performed, and how it could be applied to current clinical scenarios. A DSS/AOM murine model has allowed for a better understanding of the pathogenic mechanisms in colitis-associated cancer, as it is currently the closest model to this unique scenario. In this review, we provide a summary of the main molecular mechanisms and the clinical aspects of colitis-associated cancer in ulcerative colitis.https://www.mdpi.com/2073-4409/14/3/162ulcerative colitisdysplasiamolecular mechanismscolitis-associated cancer |
| spellingShingle | Jesus K. Yamamoto-Furusho Fausto D. Gutierrez-Herrera Molecular Mechanisms and Clinical Aspects of Colitis-Associated Cancer in Ulcerative Colitis Cells ulcerative colitis dysplasia molecular mechanisms colitis-associated cancer |
| title | Molecular Mechanisms and Clinical Aspects of Colitis-Associated Cancer in Ulcerative Colitis |
| title_full | Molecular Mechanisms and Clinical Aspects of Colitis-Associated Cancer in Ulcerative Colitis |
| title_fullStr | Molecular Mechanisms and Clinical Aspects of Colitis-Associated Cancer in Ulcerative Colitis |
| title_full_unstemmed | Molecular Mechanisms and Clinical Aspects of Colitis-Associated Cancer in Ulcerative Colitis |
| title_short | Molecular Mechanisms and Clinical Aspects of Colitis-Associated Cancer in Ulcerative Colitis |
| title_sort | molecular mechanisms and clinical aspects of colitis associated cancer in ulcerative colitis |
| topic | ulcerative colitis dysplasia molecular mechanisms colitis-associated cancer |
| url | https://www.mdpi.com/2073-4409/14/3/162 |
| work_keys_str_mv | AT jesuskyamamotofurusho molecularmechanismsandclinicalaspectsofcolitisassociatedcancerinulcerativecolitis AT faustodgutierrezherrera molecularmechanismsandclinicalaspectsofcolitisassociatedcancerinulcerativecolitis |