Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans
Abstract Regular voluntary exercise has been shown to increase waste transport through the glymphatic system in mice. Here, we investigate the impact of physical exercise on both upstream and downstream brain waste clearance in healthy volunteers via noninvasive MR imaging. Putative glymphatic influ...
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Nature Portfolio
2025-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-58726-1 |
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| author | Roh-Eul Yoo Jun-Hee Kim Hyo Youl Moon Jae Yeon Park Seongmin Cheon Hyun-Suk Shin Dohyun Han Yukyoum Kim Sung-Hong Park Seung Hong Choi |
| author_facet | Roh-Eul Yoo Jun-Hee Kim Hyo Youl Moon Jae Yeon Park Seongmin Cheon Hyun-Suk Shin Dohyun Han Yukyoum Kim Sung-Hong Park Seung Hong Choi |
| author_sort | Roh-Eul Yoo |
| collection | DOAJ |
| description | Abstract Regular voluntary exercise has been shown to increase waste transport through the glymphatic system in mice. Here, we investigate the impact of physical exercise on both upstream and downstream brain waste clearance in healthy volunteers via noninvasive MR imaging. Putative glymphatic influx, evaluated using intravenous contrast-enhanced dynamic T1 mapping, increases significantly at the putamen after 12 weeks of long-term exercise using a cycle ergometer. The putative meningeal lymphatic vessel size and flow, measured by intravenous contrast-enhanced black-blood imaging and IR-ALADDIN technique, increase significantly after long-term exercise. Plasma proteomics reveals significant changes in inflammation-related and immune-related proteins (down-regulated: S100A8, S100A9, PSMA3, and DEFA1A3; up-regulated: J chain) after long-term exercise, which correlate with putative glymphatic influx or mLV flow. Our results suggest that increased glymphatic and mLV flow may be the potential mechanism underlying the neuroprotective effects of exercise on cognition, highlighting the importance of long-term, regular exercise. |
| format | Article |
| id | doaj-art-a5e76b203f0e4273a2dd5f619f25e11a |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-a5e76b203f0e4273a2dd5f619f25e11a2025-08-20T02:17:05ZengNature PortfolioNature Communications2041-17232025-04-0116111010.1038/s41467-025-58726-1Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humansRoh-Eul Yoo0Jun-Hee Kim1Hyo Youl Moon2Jae Yeon Park3Seongmin Cheon4Hyun-Suk Shin5Dohyun Han6Yukyoum Kim7Sung-Hong Park8Seung Hong Choi9Department of Radiology, Seoul National University College of MedicineMedical Research Center, Seoul National UniversityDepartment of Physical Education, Seoul National UniversityDepartment of Physical Education, Seoul National UniversitySchool of Biological Sciences and Technology, Chonnam National UniversityProteomics Core Facility, Biomedical Research Institute, Seoul National University HospitalProteomics Core Facility, Biomedical Research Institute, Seoul National University HospitalDepartment of Physical Education, Seoul National UniversityDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)Department of Radiology, Seoul National University College of MedicineAbstract Regular voluntary exercise has been shown to increase waste transport through the glymphatic system in mice. Here, we investigate the impact of physical exercise on both upstream and downstream brain waste clearance in healthy volunteers via noninvasive MR imaging. Putative glymphatic influx, evaluated using intravenous contrast-enhanced dynamic T1 mapping, increases significantly at the putamen after 12 weeks of long-term exercise using a cycle ergometer. The putative meningeal lymphatic vessel size and flow, measured by intravenous contrast-enhanced black-blood imaging and IR-ALADDIN technique, increase significantly after long-term exercise. Plasma proteomics reveals significant changes in inflammation-related and immune-related proteins (down-regulated: S100A8, S100A9, PSMA3, and DEFA1A3; up-regulated: J chain) after long-term exercise, which correlate with putative glymphatic influx or mLV flow. Our results suggest that increased glymphatic and mLV flow may be the potential mechanism underlying the neuroprotective effects of exercise on cognition, highlighting the importance of long-term, regular exercise.https://doi.org/10.1038/s41467-025-58726-1 |
| spellingShingle | Roh-Eul Yoo Jun-Hee Kim Hyo Youl Moon Jae Yeon Park Seongmin Cheon Hyun-Suk Shin Dohyun Han Yukyoum Kim Sung-Hong Park Seung Hong Choi Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans Nature Communications |
| title | Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans |
| title_full | Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans |
| title_fullStr | Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans |
| title_full_unstemmed | Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans |
| title_short | Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans |
| title_sort | long term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans |
| url | https://doi.org/10.1038/s41467-025-58726-1 |
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