Research progress in the role of SIRT6 in aging and metabolism
SIRT6, a member of the sirtuin family of histone deacetylases, belongs to the class Ⅲ longevity proteins and exhibits NAD+-dependent deacetylase and mono-ADP-ribosyltransferase activities. SIRT6 is primarily located in the cell nucleus and plays a pivotal role in regulating genomic stability and rel...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
2024-11-01
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| Series: | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| Subjects: | |
| Online Access: | https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-11-1439.shtml |
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| _version_ | 1846116407175020544 |
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| author | LIU Yonghui TANG Li LIANG Taigang ZHANG Jian FENG Li |
| author_facet | LIU Yonghui TANG Li LIANG Taigang ZHANG Jian FENG Li |
| author_sort | LIU Yonghui |
| collection | DOAJ |
| description | SIRT6, a member of the sirtuin family of histone deacetylases, belongs to the class Ⅲ longevity proteins and exhibits NAD+-dependent deacetylase and mono-ADP-ribosyltransferase activities. SIRT6 is primarily located in the cell nucleus and plays a pivotal role in regulating genomic stability and relative gene expression, participating in the control of key processes such as energy metabolism and aging. Given its crucial role in maintaining cellular homeostasis and organismal health, SIRT6 has emerged as a potential therapeutic target, sparking significant research interest in the development of targeted modulators. Activating the longevity protein with drugs may provide therapeutic strategies for age-associated diseases, including aging, metabolic syndrome, inflammation, and reproductive health issues. The review elaborates the structural characteristics, enzymatic activities, and biological functions of SIRT6, as well as the mechanisms of action, pharmacological activities, and clinical applications of various SIRT6 activators. |
| format | Article |
| id | doaj-art-a5e63466fed44c6fa7204357c3e27d0c |
| institution | Kabale University |
| issn | 1674-8115 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) |
| record_format | Article |
| series | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| spelling | doaj-art-a5e63466fed44c6fa7204357c3e27d0c2024-12-19T02:09:02ZzhoEditorial Office of Journal of Shanghai Jiao Tong University (Medical Science)Shanghai Jiaotong Daxue xuebao. Yixue ban1674-81152024-11-0144111439144610.3969/j.issn.1674-8115.2024.11.0111674-8115（2024）11-1439-08Research progress in the role of SIRT6 in aging and metabolismLIU Yonghui0TANG Li1LIANG Taigang2ZHANG Jian3FENG Li4School of Pharmacy, Shanxi Medical University, Taiyuan030001, ChinaSchool of Pharmacy, Shanxi Medical University, Taiyuan030001, ChinaSchool of Pharmacy, Shanxi Medical University, Taiyuan030001, ChinaMedicinal Chemistry and Bioinformatics Center, Shanghai Jiao Tong University School of Medicine, Shanghai200025, ChinaMedicinal Chemistry and Bioinformatics Center, Shanghai Jiao Tong University School of Medicine, Shanghai200025, ChinaSIRT6, a member of the sirtuin family of histone deacetylases, belongs to the class Ⅲ longevity proteins and exhibits NAD+-dependent deacetylase and mono-ADP-ribosyltransferase activities. SIRT6 is primarily located in the cell nucleus and plays a pivotal role in regulating genomic stability and relative gene expression, participating in the control of key processes such as energy metabolism and aging. Given its crucial role in maintaining cellular homeostasis and organismal health, SIRT6 has emerged as a potential therapeutic target, sparking significant research interest in the development of targeted modulators. Activating the longevity protein with drugs may provide therapeutic strategies for age-associated diseases, including aging, metabolic syndrome, inflammation, and reproductive health issues. The review elaborates the structural characteristics, enzymatic activities, and biological functions of SIRT6, as well as the mechanisms of action, pharmacological activities, and clinical applications of various SIRT6 activators.https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-11-1439.shtmlsirt6catalytic activityagingmetabolisminflammationdrug discovery |
| spellingShingle | LIU Yonghui TANG Li LIANG Taigang ZHANG Jian FENG Li Research progress in the role of SIRT6 in aging and metabolism Shanghai Jiaotong Daxue xuebao. Yixue ban sirt6 catalytic activity aging metabolism inflammation drug discovery |
| title | Research progress in the role of SIRT6 in aging and metabolism |
| title_full | Research progress in the role of SIRT6 in aging and metabolism |
| title_fullStr | Research progress in the role of SIRT6 in aging and metabolism |
| title_full_unstemmed | Research progress in the role of SIRT6 in aging and metabolism |
| title_short | Research progress in the role of SIRT6 in aging and metabolism |
| title_sort | research progress in the role of sirt6 in aging and metabolism |
| topic | sirt6 catalytic activity aging metabolism inflammation drug discovery |
| url | https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-11-1439.shtml |
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